MX2015001835A - Nuevos compuestos antibacterianos. - Google Patents

Nuevos compuestos antibacterianos.

Info

Publication number
MX2015001835A
MX2015001835A MX2015001835A MX2015001835A MX2015001835A MX 2015001835 A MX2015001835 A MX 2015001835A MX 2015001835 A MX2015001835 A MX 2015001835A MX 2015001835 A MX2015001835 A MX 2015001835A MX 2015001835 A MX2015001835 A MX 2015001835A
Authority
MX
Mexico
Prior art keywords
compounds
antibacterial compounds
new antibacterial
inhibit
preparing
Prior art date
Application number
MX2015001835A
Other languages
English (en)
Other versions
MX363480B (es
Inventor
Jerôme Emile Georges Guillemont
Anil Koul
David Francis Alain Lançois
Magali Madeleine Simone Motte
Wendy Mia Albert Balemans
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2015001835A publication Critical patent/MX2015001835A/es
Publication of MX363480B publication Critical patent/MX363480B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I) novedosos que pueden inhibir la actividad de la enzima FabI y los cuales son útiles en el tratamiento de infecciones bacterianas; también se refiere a composiciones farmacéuticas que comprenden estos compuestos y a procesos químicos para preparar estos compuestos. (ver Fórmula).
MX2015001835A 2012-08-10 2013-08-09 Compuestos bacterianos que constan de un grupo heterocicloalquilo basado en nitrógeno que contiene un doble enlace unido a carbonilo que inhiben la enzima fabi. MX363480B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12180103 2012-08-10
PCT/EP2013/066681 WO2014023815A1 (en) 2012-08-10 2013-08-09 New antibacterial compounds

Publications (2)

Publication Number Publication Date
MX2015001835A true MX2015001835A (es) 2015-09-29
MX363480B MX363480B (es) 2019-03-22

Family

ID=47002583

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015001835A MX363480B (es) 2012-08-10 2013-08-09 Compuestos bacterianos que constan de un grupo heterocicloalquilo basado en nitrógeno que contiene un doble enlace unido a carbonilo que inhiben la enzima fabi.

Country Status (13)

Country Link
US (1) US9296760B2 (es)
EP (1) EP2882739B1 (es)
JP (1) JP6250668B2 (es)
KR (1) KR102323876B1 (es)
CN (1) CN104781250B (es)
AU (1) AU2013301452B2 (es)
BR (1) BR112015002931B1 (es)
CA (1) CA2880262C (es)
EA (1) EA201590331A1 (es)
ES (1) ES2634999T3 (es)
HK (1) HK1212677A1 (es)
MX (1) MX363480B (es)
WO (1) WO2014023815A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
US11225487B2 (en) * 2017-02-17 2022-01-18 Trevena, Inc. 7-membered aza-heterocyclic containing δ-opioid receptor modulating compounds, methods of using and making the same
AU2018221148B2 (en) 2017-02-17 2022-05-05 Trevena, Inc. 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
KR102037494B1 (ko) 2017-12-11 2019-10-28 씨제이헬스케어 주식회사 광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법
KR20190120112A (ko) 2019-10-08 2019-10-23 씨제이헬스케어 주식회사 광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60029235T2 (de) 1999-10-08 2007-06-14 Affinium Pharmaceuticals, Inc., Toronto Fab-i-hemmer
AU1192501A (en) 1999-10-08 2001-04-23 Smithkline Beecham Corporation Fab i inhibitors
ATE285821T1 (de) 1999-10-08 2005-01-15 Affinium Pharm Inc Fab i inhibitoren
CA2444597A1 (en) 2001-04-06 2002-10-06 Affinium Pharmaceuticals, Inc. Fab i inhibitors
KR101299399B1 (ko) * 2004-06-04 2013-08-22 아피늄 파마슈티컬스, 인크. 치료제, 및 그의 제조 및 사용 방법
US7973060B2 (en) 2005-10-13 2011-07-05 Crystalgenomics, Inc. Fab I inhibitor and process for preparing same
JP2009091251A (ja) * 2006-01-30 2009-04-30 Meiji Seika Kaisha Ltd 新規ＦａｂＫおよびＦａｂＩ／Ｋ阻害剤とその製造法
EP3255045A1 (en) * 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
EP2501693B1 (en) * 2009-11-18 2014-09-17 FAB Pharma SAS Aza heterocyclic acrylamides and their use as bactericides
MY165902A (en) * 2011-12-02 2018-05-18 Aurigene Discovery Tech Ltd Substituted pyridine derivatives as fabi inhibitors

Also Published As

Publication number Publication date
KR20150042801A (ko) 2015-04-21
AU2013301452A1 (en) 2015-02-05
HK1212677A1 (zh) 2016-06-17
CN104781250B (zh) 2017-05-10
KR102323876B1 (ko) 2021-11-09
BR112015002931B1 (pt) 2019-10-29
AU2013301452B2 (en) 2017-06-01
MX363480B (es) 2019-03-22
WO2014023815A1 (en) 2014-02-13
CA2880262A1 (en) 2014-02-13
BR112015002931A2 (pt) 2017-08-08
EP2882739A1 (en) 2015-06-17
EA201590331A1 (ru) 2016-05-31
EP2882739B1 (en) 2017-05-03
ES2634999T3 (es) 2017-10-02
CA2880262C (en) 2021-11-16
JP2015524463A (ja) 2015-08-24
JP6250668B2 (ja) 2017-12-20
US20150225424A1 (en) 2015-08-13
CN104781250A (zh) 2015-07-15
US9296760B2 (en) 2016-03-29

Similar Documents

Publication Publication Date Title
PH12017501921A1 (en) Novel compounds
MX2014001599A (es) 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con piperidinilo antibacterianas.
PH12015501385A1 (en) Autotaxin inhibitors
NZ708928A (en) Mannose derivatives for treating bacterial infections
TN2014000138A1 (en) Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases.
PH12014501671A1 (en) Amidine substituted beta-lactam compounds, their preparation and use as antibacterial agents
MX349827B (es) Compuestos que contienen nitrogeno y su uso.
UA111210C2 (uk) Антибактеріальні 3,4-дигідро-1h-[1,8]нафтиридинони, заміщені циклопента[c]піролом
PH12015501609A1 (en) Phenicol antibacterials
MX360856B (es) 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas.
MX367309B (es) Nuevos compuestos antibacterianos.
MX2011008043A (es) Derivados de actagardina.
PH12015501175A1 (en) Substituted pyridopyrazines as syk inhibitors
MX2017007377A (es) Compuestos organicos.
MX363480B (es) Compuestos bacterianos que constan de un grupo heterocicloalquilo basado en nitrógeno que contiene un doble enlace unido a carbonilo que inhiben la enzima fabi.
WO2013166282A3 (en) Methods and compositions for treating bacterial infection
MX357352B (es) Uso de derivados poliaminoisoprenilo en un tratamiento antibiotico o antiseptico.
IN2015DN02109A (es)
EA201270817A1 (ru) Соединения, обладающие антибактериальной активностью в отношении clostridium
MX2017007380A (es) Compuestos organicos.
EA201591192A1 (ru) Антибактериальные соединения
MY182136A (en) Pharmaceutical compositions