CO7310531A2 - 4-metil-2,3,8,9,9b-pentaaza-ciclopenta [a] naftalenos - Google Patents

4-metil-2,3,8,9,9b-pentaaza-ciclopenta [a] naftalenos

Info

Publication number
CO7310531A2
CO7310531A2 CO15018184A CO15018184A CO7310531A2 CO 7310531 A2 CO7310531 A2 CO 7310531A2 CO 15018184 A CO15018184 A CO 15018184A CO 15018184 A CO15018184 A CO 15018184A CO 7310531 A2 CO7310531 A2 CO 7310531A2
Authority
CO
Colombia
Prior art keywords
methyl
pentaaza
naphthalenes
cyclopenta
diseases
Prior art date
Application number
CO15018184A
Other languages
English (en)
Inventor
Riccardo Giovannini
Barbara Bertani
Sara Frattini
Antonio Giustino Di
Hans-Joachim Lankau
Hans Stange
Christian Grunwald
Norbert Hofgen
Barbara Langen
Ute Egerland
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48906250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7310531(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO7310531A2 publication Critical patent/CO7310531A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Abstract

La invención se refiere a derivados de 4-metil-2,3,5,9,9b-pentaazaciclopenta[a]naftaleno de la fórmula general (I) que son inhibidores de fosfodiesterasa2 y/o 10, y que son útiles en el tratamiento de enfermedades del sistema nerviosocentral y otras enfermedades. En adición, la invención se refiere a procesos para preparar composicionesfarmacéuticas así como también procesos para la elaboración de los compuestos deacuerdo con la invención.
CO15018184A 2012-07-31 2015-01-29 4-metil-2,3,8,9,9b-pentaaza-ciclopenta [a] naftalenos CO7310531A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12178713 2012-07-31

Publications (1)

Publication Number Publication Date
CO7310531A2 true CO7310531A2 (es) 2015-06-30

Family

ID=48906250

Family Applications (1)

Application Number Title Priority Date Filing Date
CO15018184A CO7310531A2 (es) 2012-07-31 2015-01-29 4-metil-2,3,8,9,9b-pentaaza-ciclopenta [a] naftalenos

Country Status (28)

Country Link
US (2) US20140045856A1 (es)
EP (1) EP2882749B1 (es)
JP (1) JP6356671B2 (es)
KR (1) KR20150037950A (es)
CN (1) CN104428302B (es)
AP (1) AP2015008202A0 (es)
AR (1) AR091939A1 (es)
AU (1) AU2013298621B2 (es)
BR (1) BR112015002118A2 (es)
CA (1) CA2880447A1 (es)
CL (1) CL2015000096A1 (es)
CO (1) CO7310531A2 (es)
EA (1) EA028958B1 (es)
EC (1) ECSP15006871A (es)
GE (1) GEP201706707B (es)
HK (1) HK1208440A1 (es)
IL (1) IL236494A0 (es)
MA (1) MA37798B1 (es)
MX (1) MX2015000965A (es)
NZ (1) NZ703797A (es)
PE (1) PE20150706A1 (es)
PH (1) PH12015500211A1 (es)
SG (1) SG11201500772VA (es)
TN (1) TN2015000022A1 (es)
TW (1) TW201418255A (es)
UA (1) UA115561C2 (es)
UY (1) UY34955A (es)
WO (1) WO2014019979A1 (es)

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EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
JP7049683B2 (ja) * 2016-04-04 2022-04-07 シノピア バイオサイエンシーズ，インク． トラピジルを使用する錐体外路症候群の処置
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JP2021504466A (ja) 2017-11-23 2021-02-15 オスロ ウニヴェルシティ ホスピタル ホーエフ 頻脈の治療

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Also Published As

Publication number Publication date
AP2015008202A0 (en) 2015-01-31
TN2015000022A1 (en) 2016-06-29
MX2015000965A (es) 2015-04-10
TW201418255A (zh) 2014-05-16
AR091939A1 (es) 2015-03-11
UA115561C2 (uk) 2017-11-27
AU2013298621B2 (en) 2017-12-21
PE20150706A1 (es) 2015-06-03
EA028958B1 (ru) 2018-01-31
JP2015523406A (ja) 2015-08-13
CA2880447A1 (en) 2014-02-06
US9085584B2 (en) 2015-07-21
US20140045856A1 (en) 2014-02-13
CN104428302B (zh) 2017-03-22
JP6356671B2 (ja) 2018-07-11
SG11201500772VA (en) 2015-02-27
BR112015002118A2 (pt) 2017-07-04
GEP201706707B (en) 2017-07-25
EA201500182A1 (ru) 2015-07-30
WO2014019979A1 (en) 2014-02-06
US20140045857A1 (en) 2014-02-13
NZ703797A (en) 2017-09-29
PH12015500211B1 (en) 2015-03-16
MA37798B1 (fr) 2018-11-30
ECSP15006871A (es) 2015-12-31
CN104428302A (zh) 2015-03-18
PH12015500211A1 (en) 2015-03-16
KR20150037950A (ko) 2015-04-08
AU2013298621A1 (en) 2015-02-05
EP2882749A1 (en) 2015-06-17
CL2015000096A1 (es) 2015-06-19
UY34955A (es) 2014-01-31
IL236494A0 (en) 2015-02-26
HK1208440A1 (en) 2016-03-04
EP2882749B1 (en) 2018-04-04

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