CO6300933A2 - Derivados de acido ciclopentanocarboxilico condensados sustituidos con acilamino y su uso como productos farmaceuticos - Google Patents

Derivados de acido ciclopentanocarboxilico condensados sustituidos con acilamino y su uso como productos farmaceuticos

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Publication number
CO6300933A2
CO6300933A2 CO10137694A CO10137694A CO6300933A2 CO 6300933 A2 CO6300933 A2 CO 6300933A2 CO 10137694 A CO10137694 A CO 10137694A CO 10137694 A CO10137694 A CO 10137694A CO 6300933 A2 CO6300933 A2 CO 6300933A2
Authority
CO
Colombia
Prior art keywords
acilamine
condensed
acid derivatives
pharmaceutical products
derivatives substituted
Prior art date
Application number
CO10137694A
Other languages
English (en)
Inventor
Matthias Shaefer
Josef Pernerstorfer
Marcel Patek
Alena Safarova
Aleksandra Weichsel
L Charlie Chen
Werngard Czechtizky
Dieter Kadereit
Hartmut Strobel
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39870123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6300933(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CO6300933A2 publication Critical patent/CO6300933A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/62—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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Abstract

La presente invención se refiere a compuestos de fórmula I, en la que A, Y, Z, R3 a R6, R20 a R22 y R50 tienen los significados que se indican en las reivindicaciones, que son valiosos compuestos activos farmacéuticos. Específicamente, son inhibidores del receptor del gen de diferenciación endotelial 2 (Edg-2, EDG2), que es activado por ácido lisofosfatídico (LPA) y también se denomina receptor LPA1, y son útiles para el tratamiento de enfermedades tales como aterosclerosis, infarto de miocardio e insuficiencia cardiaca, por ejemplo. La invención se refiere además a procedimientos para preparar los compuestos de fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.
CO10137694A 2008-05-05 2010-11-05 Derivados de acido ciclopentanocarboxilico condensados sustituidos con acilamino y su uso como productos farmaceuticos CO6300933A2 (es)

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