AR079022A1 - Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion - Google Patents

Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion

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Publication number
AR079022A1
AR079022A1 ARP100104007A AR079022A1 AR 079022 A1 AR079022 A1 AR 079022A1 AR P100104007 A ARP100104007 A AR P100104007A AR 079022 A1 AR079022 A1 AR 079022A1
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Argentina
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ring
chosen
group
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Sanofi Aventis
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Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR079022A1 publication Critical patent/AR079022A1/es

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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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Abstract

Reivindicacion 1: Un compuesto de formula 1, en cualquiera de sus formas estereoisoméricas o una mezcla de formas estereoisoméricas en cualquier proporcion, o una sal farmacéuticamente aceptable del mismo, en la que el anillo A es un anillo monocíclico, bicíclico o espirocíclico de 3 miembros a 12 miembros, que comprende 0, 1 o 2 miembros hetero del anillo iguales o diferentes elegidos entre la serie que consiste en N, N(R0), O, S, S(O) y S(O)2, y que está saturado o comprende 1 doble enlace, con la condicion de que el anillo A no sea un anillo de biciclo[3.1.0]hexano o biciclo[3.2.0]heptano que tiene los grupos N(R20) y C(O)-R50 en su posicion 3, y no sea un anillo de octahidropentaleno, octahidroindeno o decahidroazuleno que tiene los grupos N(R20) y C(O)-R50 en su posicion 2, donde el anillo A está opcionalmente sustituido en los átomos de carbono del anillo con uno o más sustituyentes iguales o diferentes elegidos entre la serie que consiste en halogeno, R1, R2, alquenilo C2-6, HO-, R1-O-, fenil-alquil C1-4-O-, R1-C(O)-O-, R1S(O)2-O-, R1-S(O)m-, H2N-, R1-NH-, R1-N(R1)-, R1-C(O)-NH, R1-C(O)-N(R1)-, R1-S(O)2-NH-, R1-S(O)2-N(R1)-, R1-C(O)-, HO-C(O)-, R1-O-C(O)-, H2N-C(O)-, R1-NH-C(O)-, R1-N(R1)-C(O)-, H2N-S(O)2-, R1-NH-S(O)2-, R1-N(R1)-S(O)2-, F5S-, NC-, oxo y metileno; Y se selecciona entre la serie que consiste en N(R10), S, O, C(R12)=C(R13), N=C(R14) y C(R15)=N; Z se selecciona entre la serie que consiste en N y C(R16); R0 se selecciona entre la serie que consiste en hidrogeno y R1; R1 se elige entre la serie que consiste en alquilo C1-6, cicloalquilo C3-7 y cicloalquil C3-7-alquil C1-4-; R2 es alquilo C1-4 que está sustituido con uno o más sustituyentes iguales o diferentes elegidos entre la serie que consiste en HO- y alquil C1-4-O-; R10 se selecciona entre la serie que consiste en hidrogeno y R11; R11, R30, R33, R35, R54, R55, R57 y R58 son, independientemente entre sí, un grupo R11, R30, R33, R35, R54, R55, R57 y R58, elegidos entre la serie que consiste en alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7 y cicloalquil C3-7-alquil C1-4- que están todos opcionalmente sustituidos con uno o más sustituyentes R70 iguales o diferentes; R12, R13, R14, R15 y R16 se eligen, independientemente entre sí, entre la serie que consiste en hidrogeno, halogeno, alquilo , HO-alquil C1-4-, alquil C1-4-O-, alquil C1-4-S(O)m, H2N-, alquil C1-4-NH-, alquil C1-4-N(alquil C1-4)-, alquil C1-4-C(O)- y NC-, o R13 o R14, junto con uno de los grupos R21 y R22 que no es el grupo de la formula (2), forma una cadena que consiste en 3 a 5 miembros de cadena de los que 0, 1 o 2 miembros de cadena son miembros hetero de cadena iguales o diferentes elegidos entre la serie que consiste en N(R17), O y S, pero dos miembros hetero de cadena no pueden estar presentes en posiciones adyacentes, y los otros miembros de cadena son grupos C(R18)(R18) iguales o diferentes; R17 y R25 se seleccionan, independientemente uno del otro, de la serie que consiste en hidrogeno y alquilo C1-4; R18, independientemente de cualquier otro grupo R18, se elige entre la serie que consiste en hidrogeno, fluor y alquilo C1-4, o dos de los grupos R18 unidos al mismo átomo de carbono, junto con el átomo de carbono que los tiene, forma un anillo cicloalcano de 3 miembros a 6 miembros que está opcionalmente sustituido con uno o más sustituyentes iguales o diferentes elegidos entre la serie que consiste en fluor y alquilo C1-4; R20 se selecciona entre la serie que consiste en hidrogeno y alquilo C1-4; uno de los grupos R21 y R22 es un grupo de la formula (2) (R24-R23-) y el otro de los grupos R21 y R22 se elige entre la serie que consiste en hidrogeno, halogeno, R30, HO-, R30-O-, R30-C(O)-O-, R30-S(O)2-O-, R30-S(O)m, H2N-, R30-NH-, R30-N(R30)-, R30-C(O)-NH-, R30-C(O)-N(R71)-, R30-S(O)2-NH-, R30-S(O)2-N(R71)-, R30-C(O)-, HO-C(O)-, R30-O-C(O)-, H2N-C(O)-, R30-NH-C(O)-, R30-N(R30)-C(O)-, H2N-S(O)2-, R30-NH-S(O)2-, R30-N(R30)-S(O)2-, NC-, O2N- y Het1, o junto con R13 o R14 forma una cadena como se ha especificado en la definicion de R13 y R14; R23 es un enlace directo o una cadena que consiste en 1 a 5 miembros de cadena de los que 0, 1 o 2 miembros de cadena son miembros hetero de cadena iguales o diferentes elegidos entre la serie que consiste en N(R25), O, S, S(O) y S(O)2, pero dos miembros hetero de cadena pueden estar presentes en posiciones adyacentes solo si uno de ellos se elige entre la serie que consiste en S(O) y S(O)2 y el otro se elige entre la serie que consiste en N(R25), O y S, y los otros miembros de cadena son grupos C(R26)(R26) iguales o diferentes; R24 es un anillo monocíclico o bicíclico, de 3 miembros a 10 miembros, que está saturado y contiene 0 o 1 miembros hetero del anillo, o está insaturado y contiene 0, 1 o 2 miembros hetero del anillo iguales o diferentes, donde los miembros hetero del anillo se eligen entre la serie que consiste en N, N(R32), O, S, S(O) y S(O)2, y donde el anillo está opcionalmente sustituido en los átomos de carbono del anillo con uno o más sustituyentes iguales o diferentes elegidos entre la serie que consiste en halogeno, R33, oxetanilo, HO-, R33-O-, R33-C(O)-O-, R33-S(O)2-O-, R33-S(O)m-, H2N-, R33-NH-, R33-N(R33)-, R33-C(O)-NH-, R33-C(O)-N(R71)-, R33-S(O)2-NH-, R33-S(O)2-N(R71)-, H2N-S(O)2-NH-, R33-NH-S(O)2-NH-, R33-N(R33)-S(O)2-NH-, H2N-S(O)2-N(R71)-, R33-NH-S(O)2-N(R71)-, R33-N(R33)-S(O)2-N(R71)-, R33-C(O)-, HO-C(O)-, R33-O-C(O)-, H2N-C(O)-, R33-NH-C(O)-, R33-N(R33)-C(O)-, H2N-S(O)2-, R33-NH-S(O)2-, R33-N(R33)-S(O)2-, NC-, O2N- y oxo; R26, independientemente de cualquier otro grupo R26, se selecciona entre la serie que consiste en hidrogeno, fluor, alquilo C1-4 y HO-, o dos grupos R26 unidos al mismo átomo de carbono son oxo, o dos de los grupos R26 o un grupo R25 y un grupo R26, junto con los miembros de cadena comprendidos, forman un anillo monocíclico de 3 a 7 miembros que está saturado y contiene 0, 1 o 2 miembros de anillo hetero iguales o diferentes seleccionados de la serie que consiste en N, N(R34), O, S, S(O) y S(O)2, donde el anillo está opcionalmente sustituido en átomos de carbono del anillo por uno o más sustituyentes iguales o diferentes seleccionados de la serie que consiste en fluor y alquilo C1-4; R32 y R34 se eligen, independientemente entre sí, entre la serie que consiste en hidrogeno, R35, R35-S(O)2-, R35-C(O)-, R35-O-C(O)- y fenilo; R50 se selecciona entre la serie que consiste en R51-O- y R52-N(R53)-; R51 se selecciona entre la serie que consiste en hidrogeno y R54; R52 se selecciona entre la serie que consiste en hidrogeno, R55, NC- y R56-S(O)2-; R53 se selecciona entre la serie que consiste en hidrogeno y R57; R56 se selecciona entre la serie que consiste en R58 y fenilo; R60, independientemente de cualquier otro grupo R60, se selecciona entre la serie que consiste en hidrogeno y alquilo C1-4; R70 se elige entre la serie que consiste en HO-, R71-O-, R71-C(O)-O-, R71-S(O)m-, H2N-, R71-NH-, R71-N(R71)-, R71-C(O)-NH-, R71-C(O)-N(R71)-, R71-S(O)2-NH-, R71-S(O)2-N(R71)-, HO-C(O)-, R71-O-C(O)-, H2N-C(O)-, R71-NH-C(O)-, R71-N(R71)-C(O)-, H2N-S(O)2-, R71-NH-S(O)2-, R71-N(R71)-S(O)2- y oxo; R71, independientemente de cualquier otro grupo R71, se selecciona entre alquilo C1-4, cicloalquilo C3-4 y cicloalquil C3-4-alquilo C1-2-; Het1 es un anillo heterocíclico de 4 a 7 miembros monocíclico que comprende 1 o 2 miembros de anillo hetero iguales o diferentes seleccionados de la serie que consiste en N, N(R60), O, S, S(O) y S(O)2, donde el anillo está saturado y está opcionalmente sustituido con uno o más sustituyentes iguales o diferentes seleccionados de la serie que consiste en fluor y alquilo C1-4; m, independientemente de cualquier otro numero m, es un numero entero seleccionado de la serie que consiste en 0, 1 y 2; fenilo, independientemente de cualquier otro grupo fenilo, está opcionalmente sustituido con uno o más sustituyentes iguales o diferentes seleccionados de la serie que consiste en halogeno, alquilo C1-4, alquil C1-4-O- y NC-, a menos que se especifique lo contrario; cicloalquilo, independientemente de cualquier otro grupo cicloalquilo, e independientemente de cualquier otro sustituyente en el cicloalquilo, está opcionalmente sustituido con uno o más sustituyentes iguales o diferentes seleccionados de fluor y alquilo C1-4; alquilo, alquenilo y alquinilo, independientemente del grupo alquilo, alquenilo y alquinilo, e independientemente de cualquier otro sustituyente en alquilo, alquenilo y alquinilo, está opcionalmente sustituido con uno o más sustituyentes fluor; con la condicion de que el compuesto de la formula (1) no sea ácido 1-[(bifenil-4-carbonil)-amino]-ciclohexanocarboxílico, ácido 1-[4-(2-pirrolidin-1-il-etoxi)-benzoilamino]-ciclohexanocarboxílico, ácido 1-[4-(2-piperidin-1-il-etoxi)-benzoilamino]-ciclohexanocarboxílico, ácido 1-[4-(2-oxo-pirrolidin-1-il)-benzoilamino]-ciclohexanocarboxílico, ácido 1-{[4-(2-oxo-pirrolidin-1-il)-furan-2-carbonil]-amino}-ciclohexanocarboxílico, ácido 1-[(2',3-dicloro-bifenil-4-carbonil)-amino]-cicloheptanocarboxílico, éster metílico del ácido 1-[4-(4,6-dimetil-pirimidin-2-ilsulfanil)-benzoilamino]-ciclopentanocarboxílico, éster etílico del ácido 1-[4-(4-oxo-piperidin-1-iI)-benzoilamino]-ciclopropanocarboxílico o ácido 1-[2-cloro-4-(3-hidroxi- bencilcarbamoil)-benzoilamino]-ciclopropanocarboxílico. Reivindicacion 9: Un procedimiento para la preparacion de un compuesto de la formula (1) o una sal farmacéuticamente aceptable del mismo de acuerdo con una cualquiera o más de las reivindicaciones 1 a 8, que comprende hacer reaccionar un compuesto de la formula (3) con un compuesto de la formula (4), donde el anillo A y los grupos Y, Z, R20 a R22 y R50 en los compuestos de las formulas (3) y (4) se definen como en los compuestos de la formula (1) y pueden estar presentes grupos funcionales adicionales en forma protegida o en la forma de un grupo precursor, y el grupo G en el compuesto de la formula (4) es HO-, alquil C1-4-O- o halogeno. Reivindicaci
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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012000435A (es) 2009-07-08 2012-06-01 Dermira Canada Inc Analogos de acido 5-(tetradeciloxi)-2-furancarboxilico (tofa) utiles en el tratamiento de trastornos o afecciones dermatologicas.
JP2014525932A (ja) 2011-08-15 2014-10-02 インターミューン， インコーポレイテッド リゾホスファチド酸レセプターアンタゴニスト
WO2013070879A1 (en) 2011-11-10 2013-05-16 Bristol-Myers Squibb Company Methods for treating spinal cord injury with lpa receptor antagonists
US9254288B2 (en) * 2012-05-07 2016-02-09 The Translational Genomics Research Institute Susceptibility of tumors to tyrosine kinase inhibitors and treatment thereof
CA2872213A1 (en) 2012-06-13 2013-12-19 F. Hoffmann-La Roche Ag New diazaspirocycloalkane and azaspirocycloalkane
AR092645A1 (es) 2012-09-25 2015-04-29 Hoffmann La Roche Derivados biciclicos inhibidores de autotaxina (atx)
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
UA118201C2 (uk) 2013-11-26 2018-12-10 Ф. Хоффманн-Ля Рош Аг НОВИЙ ОКТАГІДРОЦИКЛОБУТА[1,2-c;3,4-c']ДИПІРОЛ-2-ІЛ
EP3122750B1 (en) 2014-03-26 2019-09-04 F.Hoffmann-La Roche Ag Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
MX2016010675A (es) 2014-03-26 2016-11-10 Hoffmann La Roche Compuestos condensados de [1,4]diazepina como inhibidores de produccion de la autotaxina (atx) y acido lisofosfatidico (lpa).
AU2015339089B2 (en) 2014-10-30 2020-07-16 Janssen Pharmaceutica Nv Thiazoles as modulators of RORgammat
PL3212642T3 (pl) 2014-10-30 2020-04-30 Janssen Pharmaceutica Nv Tiazole podstawione amidami jako modulatory rorgammat
JOP20200117A1 (ar) 2014-10-30 2017-06-16 Janssen Pharmaceutica Nv كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
US10118904B2 (en) 2015-06-05 2018-11-06 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of Demyelinating Diseases
MX2020004504A (es) 2015-09-04 2021-11-10 Hoffmann La Roche Derivados de fenoximetilo.
EP3353181B1 (en) 2015-09-24 2021-08-11 F. Hoffmann-La Roche AG Bicyclic compounds as dual atx/ca inhibitors
MX2018001890A (es) 2015-09-24 2018-06-20 Hoffmann La Roche Compuestos biciclicos como inhibidores de autotaxina (atx).
RU2018114289A (ru) 2015-09-24 2019-10-24 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов аутотаксина (atx)
BR112018006080A2 (pt) 2015-09-24 2018-10-09 F. Hoffmann-La Roche Ag novos compostos bicíclicos como inibidores de dupla ação de atx/ca
TW201803869A (zh) 2016-04-27 2018-02-01 健生藥品公司 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
NZ755597A (en) 2017-02-17 2023-06-30 Eidos Therapeutics Inc Processes for preparing ag-10, its intermediates, and salts thereof
CR20190423A (es) 2017-03-16 2019-11-01 Hoffmann La Roche Nuevos compuestos biciclícos como inhibidores dobles de atx/ca
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
KR101798840B1 (ko) 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
CN108276307A (zh) * 2018-01-17 2018-07-13 常熟浸大科技有限公司 3-氰基-4-烃氧基苯甲酸酯的合成方法
WO2019183463A1 (en) 2018-03-23 2019-09-26 Eidos Therapeutics, Inc. Methods of treating ttr amyloidosis using ag10
WO2019244002A1 (en) 2018-06-18 2019-12-26 Janssen Pharmaceutica Nv Pyridinyl pyrazoles as modulators of roryt
US11345666B2 (en) 2018-06-18 2022-05-31 Janssen Pharmaceutica Nv Phenyl and pyridinyl substituted imidazoles as modulators of RORγT
CN112292183A (zh) 2018-06-18 2021-01-29 詹森药业有限公司 作为RORγt的调节剂的6-氨基吡啶-3-基吡唑
JP2021528405A (ja) 2018-06-18 2021-10-21 ヤンセン ファーマシューティカ エヌ．ベー． ＲＯＲγｔのモジュレータとしてのアミド置換チアゾール
US20200085810A1 (en) * 2018-07-26 2020-03-19 Hoffmann-La Roche Inc. Compounds for use in treating kidney disorders
MA53238A (fr) 2018-08-17 2022-04-13 Eidos Therapeutics Inc Formules d'ag10
KR102224677B1 (ko) * 2018-08-23 2021-03-08 가천대학교 산학협력단 티아졸로 피페라진 유도체 및 이를 유효성분으로 함유하는 자가면역질환 예방 또는 치료용 조성물
KR20220101137A (ko) 2019-11-15 2022-07-19 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제로서의 트라이아졸 카르바메이트 피리딜 설폰아미드 및 이의 용도
CN111574389B (zh) * 2020-05-14 2023-08-18 河北威远生物化工有限公司 1-氨基-4-取代环己基羧酸及其盐的顺式异构体的制备方法
TW202344504A (zh) 2020-06-03 2023-11-16 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
WO2021247215A1 (en) 2020-06-03 2021-12-09 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
WO2023107938A1 (en) 2021-12-08 2023-06-15 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
TW202342017A (zh) 2022-02-25 2023-11-01 美商洛子峰生物有限公司 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5259644A (en) * 1975-11-11 1977-05-17 Sankyo Co Ltd Stabilizer for polymer
DE3602016A1 (de) 1985-12-05 1987-06-11 Bayer Ag Pyri(mi)dyl-oxy- und thio-benzoesaeure-derivate
DE69430747T2 (de) 1993-07-28 2003-03-06 Aventis Pharma Ltd Verbindungen als pde iv und tnf inhibitoren
KR20010082515A (ko) * 1998-02-17 2001-08-30 우에노 도시오 아미디노 유도체 및 그 유도체를 유효 성분으로서함유하는 약제
HUP0101587A3 (en) 1998-03-27 2003-03-28 Genentech Inc Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders
PL350456A1 (en) * 1999-03-15 2002-12-16 Axys Pharmaceuticals N−cyanomethylamides as protease inhibitors
ATE420878T1 (de) 2000-02-18 2009-01-15 Kyowa Hakko Kirin Co Ltd Isoxazol- und thiazolverbindungen und ihre verwendung als medikamente
DE10033353A1 (de) 2000-07-08 2002-01-24 Aventis Pharma Gmbh Breit einsetzbares Verfahren zur Identifizierung von Modulatoren von G-Protein gekoppelten Rezeptoren
US6525202B2 (en) 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
EP1361872A4 (en) 2000-10-03 2004-05-19 Univ Virginia NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS
JP2005519915A (ja) 2002-01-18 2005-07-07 セレテック・リミテッド・ライアビリティ・カンパニー Ｅｄｇ受容体に関連する症状の処置方法
AU2003241833A1 (en) 2002-05-28 2003-12-12 Ono Pharmaceutical Co., Ltd. Beta-ALANINE DERIVATIVE AND USE THEREOF
KR100962972B1 (ko) * 2002-07-26 2010-06-09 주식회사유한양행 1-페닐피페리딘-3-온 유도체 및 그의 제조방법
US20060122184A1 (en) 2002-12-05 2006-06-08 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
JP2006527200A (ja) 2003-06-06 2006-11-30 ファイブロゲン インコーポレイティッド 窒素含有ヘテロアリール化合物および内因性エリトロポエチンを増加させる際のそれらの使用方法
CA2532800C (en) 2003-07-23 2013-06-18 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
MXPA06002019A (es) 2003-08-21 2006-05-31 Osi Pharm Inc Imidazopiridinas n3 sustituidas inhibidoras de c_kit.
WO2005058790A1 (ja) 2003-12-19 2005-06-30 Ono Pharmaceutical Co., Ltd. リゾホスファチジン酸受容体拮抗作用を有する化合物およびその用途
US7820703B2 (en) 2004-05-06 2010-10-26 University Of Virginia Patent Foundation Lysophosphatidic acid receptor selective antagonists
US7683097B2 (en) * 2004-05-27 2010-03-23 Propharmacon Inc. Topoisomerase inhibitors
GB2414403B (en) 2004-05-28 2009-01-07 Cilag Ag Int Injection device
MX2007004217A (es) * 2004-10-15 2007-06-11 Bayer Pharmaceuticals Corp Preparacion y uso de derivados de acido bifenil-4-il-carbonilamino para el tratamiento de obesidad.
EP1802606B1 (en) 2004-10-19 2011-03-16 Compass Pharmaceuticals LLC Arylcarboxamides and their use as anti-tumor agents
CN101098852A (zh) * 2004-11-09 2008-01-02 史密丝克莱恩比彻姆公司 糖原磷酸化酶抑制剂化合物和其药物组合物
US20100130737A1 (en) 2005-02-18 2010-05-27 Takeda Pharmaceutical Company Limited Regulating Agent of GPR34 Receptor Function
WO2006128184A2 (en) 2005-05-20 2006-11-30 Alantos-Pharmaceuticals, Inc. Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
WO2007016538A2 (en) * 2005-07-29 2007-02-08 Bayer Healthcare Llc Preparation and use of biphenyl amino acid derivatives for the treatment of obesity
JP4047365B2 (ja) * 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
EP2040688B1 (en) * 2006-06-28 2014-04-02 Sanofi New cxcr2 inhibitors
FR2904827B1 (fr) * 2006-08-11 2008-09-19 Sanofi Aventis Sa Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii
UA105178C2 (ru) 2008-05-05 2014-04-25 Санофи-Авентис Ациламинозамещенные производные конденсированных циклопентанкарбоновых кислот и их применение как фармацевтических средств
TW201010997A (en) * 2008-06-18 2010-03-16 Pfizer Ltd Nicotinamide derivatives

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FA Abandonment or withdrawal