BR112012010282A2 - derivados de ácido carboxílico cíclico substituído por acilamino e seu uso como farmacêuticos - Google Patents

derivados de ácido carboxílico cíclico substituído por acilamino e seu uso como farmacêuticos

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Publication number
BR112012010282A2
BR112012010282A2 BR112012010282A BR112012010282A BR112012010282A2 BR 112012010282 A2 BR112012010282 A2 BR 112012010282A2 BR 112012010282 A BR112012010282 A BR 112012010282A BR 112012010282 A BR112012010282 A BR 112012010282A BR 112012010282 A2 BR112012010282 A2 BR 112012010282A2
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Brazil
Prior art keywords
pharmaceuticals
carboxylic acid
acid derivatives
substituted cyclic
cyclic carboxylic
Prior art date
Application number
BR112012010282A
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English (en)
Inventor
Alena Safarova
Heinz-Werner Kleemann
Josef Pernerstorfer
Marcel Patek
Matthias Schaefer
Original Assignee
Sanofi Sa
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42040612&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012010282(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112012010282A2 publication Critical patent/BR112012010282A2/pt

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Abstract

derivados de ácido carboxílico cíclico substituído por acilamino e seu uso como farmacêuticos. a presente invenção refere-se a compostos da fórmula i, em que a, y, z, r^ 20^ a r^ 22^ e r^ 50^ têm os significados indicados nas reivindicações que são valiosos compostos ativos farmacêuticos. especificamente, eles são inibidores do receptor do gene de diferenciação endotelial 2 (edg-2,edg2), que é ativado por ácido lisofosfatídico (lpa) e são da mesma forma denominados como receptor de lpa~ 1~, e são úteis para o tratamento de doenças tais como aterosclerose, infarto miocárdio e insuficiênciua cardíaca, por exemplo. a invenção refere-se além disso a processos para a preparação dos compostos da fórmula i, seu uso e composições farmacêuticas compreendendo-os.
BR112012010282A 2009-11-02 2010-11-02 derivados de ácido carboxílico cíclico substituído por acilamino e seu uso como farmacêuticos BR112012010282A2 (pt)

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CA2779268A1 (en) 2011-05-05
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