BR112012010282A2 - derivados de ácido carboxílico cíclico substituído por acilamino e seu uso como farmacêuticos - Google Patents
derivados de ácido carboxílico cíclico substituído por acilamino e seu uso como farmacêuticosInfo
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- BR112012010282A2 BR112012010282A2 BR112012010282A BR112012010282A BR112012010282A2 BR 112012010282 A2 BR112012010282 A2 BR 112012010282A2 BR 112012010282 A BR112012010282 A BR 112012010282A BR 112012010282 A BR112012010282 A BR 112012010282A BR 112012010282 A2 BR112012010282 A2 BR 112012010282A2
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- pharmaceuticals
- carboxylic acid
- acid derivatives
- substituted cyclic
- cyclic carboxylic
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- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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Abstract
derivados de ácido carboxílico cíclico substituído por acilamino e seu uso como farmacêuticos. a presente invenção refere-se a compostos da fórmula i, em que a, y, z, r^ 20^ a r^ 22^ e r^ 50^ têm os significados indicados nas reivindicações que são valiosos compostos ativos farmacêuticos. especificamente, eles são inibidores do receptor do gene de diferenciação endotelial 2 (edg-2,edg2), que é ativado por ácido lisofosfatídico (lpa) e são da mesma forma denominados como receptor de lpa~ 1~, e são úteis para o tratamento de doenças tais como aterosclerose, infarto miocárdio e insuficiênciua cardíaca, por exemplo. a invenção refere-se além disso a processos para a preparação dos compostos da fórmula i, seu uso e composições farmacêuticas compreendendo-os.
Applications Claiming Priority (3)
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EP09290831 | 2009-11-02 | ||
US31961910P | 2010-03-31 | 2010-03-31 | |
PCT/US2010/055035 WO2011053948A1 (en) | 2009-11-02 | 2010-11-02 | Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals |
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BR112012010282A2 true BR112012010282A2 (pt) | 2016-03-29 |
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BR112012010282A BR112012010282A2 (pt) | 2009-11-02 | 2010-11-02 | derivados de ácido carboxílico cíclico substituído por acilamino e seu uso como farmacêuticos |
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US (2) | US8618304B2 (pt) |
EP (1) | EP2496556B1 (pt) |
JP (1) | JP5847088B2 (pt) |
KR (1) | KR20120101429A (pt) |
CN (1) | CN102858745A (pt) |
AR (1) | AR079022A1 (pt) |
AU (1) | AU2010313162A1 (pt) |
BR (1) | BR112012010282A2 (pt) |
CA (1) | CA2779268A1 (pt) |
CO (1) | CO6541540A2 (pt) |
CR (1) | CR20120203A (pt) |
DO (1) | DOP2012000121A (pt) |
EC (1) | ECSP12011861A (pt) |
IL (1) | IL219354A0 (pt) |
MA (1) | MA33772B1 (pt) |
MX (1) | MX2012004739A (pt) |
PE (1) | PE20121477A1 (pt) |
RU (1) | RU2012122805A (pt) |
TN (1) | TN2012000160A1 (pt) |
TW (1) | TW201127379A (pt) |
UY (1) | UY32990A (pt) |
WO (1) | WO2011053948A1 (pt) |
ZA (1) | ZA201202635B (pt) |
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2010
- 2010-10-29 AR ARP100104007 patent/AR079022A1/es not_active Application Discontinuation
- 2010-11-01 UY UY32990A patent/UY32990A/es not_active Application Discontinuation
- 2010-11-01 TW TW99137400A patent/TW201127379A/zh unknown
- 2010-11-02 MX MX2012004739A patent/MX2012004739A/es not_active Application Discontinuation
- 2010-11-02 BR BR112012010282A patent/BR112012010282A2/pt not_active IP Right Cessation
- 2010-11-02 CA CA2779268A patent/CA2779268A1/en not_active Abandoned
- 2010-11-02 EP EP10776045.6A patent/EP2496556B1/en active Active
- 2010-11-02 RU RU2012122805/04A patent/RU2012122805A/ru not_active Application Discontinuation
- 2010-11-02 PE PE2012000558A patent/PE20121477A1/es not_active Application Discontinuation
- 2010-11-02 CN CN2010800603352A patent/CN102858745A/zh active Pending
- 2010-11-02 JP JP2012537183A patent/JP5847088B2/ja not_active Expired - Fee Related
- 2010-11-02 KR KR20127014323A patent/KR20120101429A/ko not_active Application Discontinuation
- 2010-11-02 AU AU2010313162A patent/AU2010313162A1/en not_active Abandoned
- 2010-11-02 WO PCT/US2010/055035 patent/WO2011053948A1/en active Application Filing
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2012
- 2012-04-04 TN TNP2012000160A patent/TN2012000160A1/en unknown
- 2012-04-12 ZA ZA2012/02635A patent/ZA201202635B/en unknown
- 2012-04-22 IL IL219354A patent/IL219354A0/en unknown
- 2012-04-25 CR CR20120203A patent/CR20120203A/es unknown
- 2012-04-26 DO DO2012000121A patent/DOP2012000121A/es unknown
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- 2012-05-02 CO CO12071019A patent/CO6541540A2/es unknown
- 2012-05-30 MA MA34905A patent/MA33772B1/fr unknown
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2013
- 2013-11-27 US US14/091,511 patent/US9018383B2/en not_active Expired - Fee Related
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US20120264790A1 (en) | 2012-10-18 |
AR079022A1 (es) | 2011-12-21 |
ECSP12011861A (es) | 2012-10-30 |
CN102858745A (zh) | 2013-01-02 |
RU2012122805A (ru) | 2013-12-10 |
CO6541540A2 (es) | 2012-10-16 |
JP5847088B2 (ja) | 2016-01-20 |
JP2013509446A (ja) | 2013-03-14 |
PE20121477A1 (es) | 2012-11-14 |
CA2779268A1 (en) | 2011-05-05 |
TN2012000160A1 (en) | 2013-12-12 |
US9018383B2 (en) | 2015-04-28 |
US8618304B2 (en) | 2013-12-31 |
ZA201202635B (en) | 2013-01-30 |
TW201127379A (en) | 2011-08-16 |
CR20120203A (es) | 2012-06-01 |
EP2496556A1 (en) | 2012-09-12 |
WO2011053948A1 (en) | 2011-05-05 |
KR20120101429A (ko) | 2012-09-13 |
MX2012004739A (es) | 2012-05-22 |
EP2496556B1 (en) | 2018-12-26 |
DOP2012000121A (es) | 2012-07-31 |
UY32990A (es) | 2011-05-31 |
MA33772B1 (fr) | 2012-11-01 |
AU2010313162A1 (en) | 2012-05-24 |
US20140088158A1 (en) | 2014-03-27 |
IL219354A0 (en) | 2012-06-28 |
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