BR112014009266A2 - processo para a preparação de ácidos isoxazolil-metóxi-nicotínicos - Google Patents
processo para a preparação de ácidos isoxazolil-metóxi-nicotínicosInfo
- Publication number
- BR112014009266A2 BR112014009266A2 BR112014009266A BR112014009266A BR112014009266A2 BR 112014009266 A2 BR112014009266 A2 BR 112014009266A2 BR 112014009266 A BR112014009266 A BR 112014009266A BR 112014009266 A BR112014009266 A BR 112014009266A BR 112014009266 A2 BR112014009266 A2 BR 112014009266A2
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- isoxazolyl
- nicotinic acids
- methoxy nicotinic
- methoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/05—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in nitriles (3.5.5)
- C12Y305/05001—Nitrilase (3.5.5.1)
Abstract
resumo patente de invenção: "processo para a preparação de ácidos isoxazolil-metóxi-nicotínicos". a presente invenção refere-se a um processo para preparação de um composto de fórmula (i) que é útil como um intermediário na preparação de compostos farmacêuticos ativos de um composto de fórmula (iv) em que r1 e r2 são como definidos aqui.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11185992.2 | 2011-10-20 | ||
EP11185992 | 2011-10-20 | ||
PCT/EP2012/070521 WO2013057123A1 (en) | 2011-10-20 | 2012-10-17 | Process for the preparation of isoxazolyl-methoxy-nicotinic acids |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112014009266A2 true BR112014009266A2 (pt) | 2017-06-13 |
BR112014009266A8 BR112014009266A8 (pt) | 2020-04-22 |
BR112014009266B1 BR112014009266B1 (pt) | 2021-05-04 |
Family
ID=47019026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014009266-4A BR112014009266B1 (pt) | 2011-10-20 | 2012-10-17 | Processos encurtado, biocatalítico e para preparação de ácidos isoxazolil-metóxinicotínicos |
Country Status (20)
Country | Link |
---|---|
US (1) | US8604062B2 (pt) |
EP (1) | EP2768827B1 (pt) |
JP (1) | JP5923174B2 (pt) |
KR (2) | KR102262697B1 (pt) |
CN (1) | CN103889978B (pt) |
AR (1) | AR088358A1 (pt) |
AU (1) | AU2012321095B2 (pt) |
BR (1) | BR112014009266B1 (pt) |
CA (2) | CA3112072C (pt) |
DK (1) | DK2768827T3 (pt) |
ES (1) | ES2613802T3 (pt) |
HU (1) | HUE031276T2 (pt) |
IL (1) | IL231645A (pt) |
MX (1) | MX2014004688A (pt) |
MY (1) | MY164880A (pt) |
PL (1) | PL2768827T3 (pt) |
RU (1) | RU2014118966A (pt) |
SG (1) | SG11201401626UA (pt) |
SI (1) | SI2768827T1 (pt) |
WO (1) | WO2013057123A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA202090521A1 (ru) * | 2017-08-28 | 2020-06-10 | Юниверсити Оф Мэриленд, Балтимор | Новые модуляторы рецептора гамма-аминомасляной кислоты типа a против расстройств настроения |
JP7478676B2 (ja) | 2018-06-13 | 2024-05-07 | エフ. ホフマン-ラ ロシュ アーゲー | Gaba a alpha5 pamとしての新規イソオキサゾリルエーテル誘導体 |
HU231223B1 (hu) | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
JP7295667B2 (ja) | 2019-03-20 | 2023-06-21 | 古河電気工業株式会社 | 保持具及び保護カバー |
WO2021191837A1 (en) | 2020-03-26 | 2021-09-30 | Richter Gedeon Nyrt. | 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2255294T3 (es) | 1998-08-07 | 2006-06-16 | Chiron Corporation | Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos. |
US6551804B2 (en) * | 1999-07-12 | 2003-04-22 | E. I. Du Pont De Nemours And Company | Process for preparing 4-cyanopentanoic acid |
US20060148858A1 (en) | 2002-05-24 | 2006-07-06 | Tsuyoshi Maekawa | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity |
GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
UA82292C2 (uk) * | 2004-04-14 | 2008-03-25 | Пфайзер Продактс Инк. | Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти) |
AU2005245411B2 (en) | 2004-05-14 | 2009-04-23 | Irm Llc | Compounds and compositions as PPAR modulators |
PL1802566T3 (pl) | 2004-10-01 | 2009-05-29 | Hoffmann La Roche | Podstawione heksafluoroizopropanolem pochodne eteru |
ATE485269T1 (de) | 2005-06-27 | 2010-11-15 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden |
JP2009508905A (ja) | 2005-09-19 | 2009-03-05 | エフ.ホフマン−ラ ロシュ アーゲー | GABAAα5逆アゴニストとしてのイソオキサゾロ誘導体 |
JP2009511533A (ja) | 2005-10-11 | 2009-03-19 | エフ.ホフマン−ラ ロシュ アーゲー | イソオキサゾール誘導体 |
ES2397401T3 (es) | 2005-12-23 | 2013-03-06 | F. Hoffmann-La Roche Ag | Derivados de aril-isoxazol-4-il-oxadiazol |
AU2008333326B2 (en) * | 2007-12-04 | 2013-05-30 | F. Hoffmann-La Roche Ag | Isoxazolo-pyridine derivatives |
AU2008333320B2 (en) | 2007-12-04 | 2012-12-20 | F. Hoffmann-La Roche Ag | Isoxazolo-pyrazine derivatives |
US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
JP2012040448A (ja) * | 2008-11-14 | 2012-03-01 | Yasutaka Sakamoto | マイクロバブル発生装置 |
US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
WO2010127978A1 (en) | 2009-05-07 | 2010-11-11 | F. Hoffmann-La Roche Ag | Isoxazole-pyridine derivatives as gaba modulators |
-
2012
- 2012-10-12 US US13/650,202 patent/US8604062B2/en active Active
- 2012-10-17 JP JP2014536208A patent/JP5923174B2/ja active Active
- 2012-10-17 PL PL12772788T patent/PL2768827T3/pl unknown
- 2012-10-17 SI SI201230864A patent/SI2768827T1/sl unknown
- 2012-10-17 AU AU2012321095A patent/AU2012321095B2/en active Active
- 2012-10-17 DK DK12772788.1T patent/DK2768827T3/en active
- 2012-10-17 EP EP12772788.1A patent/EP2768827B1/en active Active
- 2012-10-17 KR KR1020207001557A patent/KR102262697B1/ko active IP Right Grant
- 2012-10-17 MY MYPI2014001152A patent/MY164880A/en unknown
- 2012-10-17 CA CA3112072A patent/CA3112072C/en active Active
- 2012-10-17 BR BR112014009266-4A patent/BR112014009266B1/pt active IP Right Grant
- 2012-10-17 AR ARP120103859A patent/AR088358A1/es active IP Right Grant
- 2012-10-17 CA CA2850440A patent/CA2850440C/en active Active
- 2012-10-17 HU HUE12772788A patent/HUE031276T2/hu unknown
- 2012-10-17 CN CN201280051438.1A patent/CN103889978B/zh active Active
- 2012-10-17 ES ES12772788.1T patent/ES2613802T3/es active Active
- 2012-10-17 WO PCT/EP2012/070521 patent/WO2013057123A1/en active Application Filing
- 2012-10-17 MX MX2014004688A patent/MX2014004688A/es unknown
- 2012-10-17 KR KR1020147013309A patent/KR20140084209A/ko active Application Filing
- 2012-10-17 SG SG11201401626UA patent/SG11201401626UA/en unknown
- 2012-10-17 RU RU2014118966/04A patent/RU2014118966A/ru not_active Application Discontinuation
-
2014
- 2014-03-20 IL IL231645A patent/IL231645A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
HUE031276T2 (hu) | 2017-07-28 |
SG11201401626UA (en) | 2014-05-29 |
NZ622214A (en) | 2016-08-26 |
AU2012321095A1 (en) | 2013-05-09 |
MX2014004688A (es) | 2014-05-28 |
BR112014009266B1 (pt) | 2021-05-04 |
KR20140084209A (ko) | 2014-07-04 |
BR112014009266A8 (pt) | 2020-04-22 |
EP2768827A1 (en) | 2014-08-27 |
DK2768827T3 (en) | 2017-02-13 |
AR088358A1 (es) | 2014-05-28 |
US8604062B2 (en) | 2013-12-10 |
RU2014118966A (ru) | 2015-11-27 |
PL2768827T3 (pl) | 2017-05-31 |
CA2850440A1 (en) | 2013-04-25 |
KR20200008671A (ko) | 2020-01-28 |
SI2768827T1 (sl) | 2017-04-26 |
CN103889978A (zh) | 2014-06-25 |
CA2850440C (en) | 2021-05-04 |
MY164880A (en) | 2018-01-30 |
JP5923174B2 (ja) | 2016-05-24 |
KR102262697B1 (ko) | 2021-06-11 |
CN103889978B (zh) | 2017-02-15 |
IL231645A0 (en) | 2014-05-28 |
WO2013057123A1 (en) | 2013-04-25 |
JP2014530831A (ja) | 2014-11-20 |
CA3112072A1 (en) | 2013-04-25 |
CA3112072C (en) | 2023-06-13 |
IL231645A (en) | 2016-09-29 |
ES2613802T3 (es) | 2017-05-26 |
US20130102778A1 (en) | 2013-04-25 |
AU2012321095B2 (en) | 2015-08-20 |
EP2768827B1 (en) | 2016-11-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/10/2012, OBSERVADAS AS CONDICOES LEGAIS. |