ECSP12011861A - Derivados de ácido carboxílico cíclico sustituidos con acilamino y su uso como productos farmacéuticos - Google Patents
Derivados de ácido carboxílico cíclico sustituidos con acilamino y su uso como productos farmacéuticosInfo
- Publication number
- ECSP12011861A ECSP12011861A ECSP12011861A ECSP12011861A EC SP12011861 A ECSP12011861 A EC SP12011861A EC SP12011861 A ECSP12011861 A EC SP12011861A EC SP12011861 A ECSP12011861 A EC SP12011861A
- Authority
- EC
- Ecuador
- Prior art keywords
- acilamine
- derivatives
- carboxylic acid
- pharmaceutical products
- compounds
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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Abstract
La presente invención se refiere a compuestos de la fórmula I,en la que A, Y, Z, R20 a R22 y R50 tienen los significados indicados en las reivindicaciones, que son compuestos farmacéuticos activos valiosos. Específicamente, son inhibidores del receptor del gen de diferenciación endotelial 2 (Edg-2, EDG2), que se activa por el ácido lisofosfatídico (LPA) y también se denomina receptor LPA1, y son útiles para el tratamiento de enfermedades tales como aterosclerosis, infarto de miocardio e insuficiencia cardiaca, por ejemplo. La invención se refiere además a procedimientos para preparar los compuestos de la fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.
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EP09290831 | 2009-11-02 | ||
US31961910P | 2010-03-31 | 2010-03-31 |
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ECSP12011861 ECSP12011861A (es) | 2009-11-02 | 2012-04-30 | Derivados de ácido carboxílico cíclico sustituidos con acilamino y su uso como productos farmacéuticos |
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WO (1) | WO2011053948A1 (es) |
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AU2022405082A1 (en) | 2021-12-08 | 2024-07-11 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
AR128613A1 (es) | 2022-02-25 | 2024-05-29 | Lhotse Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor de lpa |
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2010
- 2010-10-29 AR ARP100104007 patent/AR079022A1/es not_active Application Discontinuation
- 2010-11-01 UY UY32990A patent/UY32990A/es not_active Application Discontinuation
- 2010-11-01 TW TW99137400A patent/TW201127379A/zh unknown
- 2010-11-02 PE PE2012000558A patent/PE20121477A1/es not_active Application Discontinuation
- 2010-11-02 CN CN2010800603352A patent/CN102858745A/zh active Pending
- 2010-11-02 AU AU2010313162A patent/AU2010313162A1/en not_active Abandoned
- 2010-11-02 BR BR112012010282A patent/BR112012010282A2/pt not_active IP Right Cessation
- 2010-11-02 KR KR20127014323A patent/KR20120101429A/ko not_active Application Discontinuation
- 2010-11-02 WO PCT/US2010/055035 patent/WO2011053948A1/en active Application Filing
- 2010-11-02 CA CA2779268A patent/CA2779268A1/en not_active Abandoned
- 2010-11-02 EP EP10776045.6A patent/EP2496556B1/en active Active
- 2010-11-02 RU RU2012122805/04A patent/RU2012122805A/ru not_active Application Discontinuation
- 2010-11-02 MX MX2012004739A patent/MX2012004739A/es not_active Application Discontinuation
- 2010-11-02 JP JP2012537183A patent/JP5847088B2/ja not_active Expired - Fee Related
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2012
- 2012-04-04 TN TNP2012000160A patent/TN2012000160A1/en unknown
- 2012-04-12 ZA ZA2012/02635A patent/ZA201202635B/en unknown
- 2012-04-22 IL IL219354A patent/IL219354A0/en unknown
- 2012-04-25 CR CR20120203A patent/CR20120203A/es unknown
- 2012-04-26 DO DO2012000121A patent/DOP2012000121A/es unknown
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- 2012-05-02 CO CO12071019A patent/CO6541540A2/es unknown
- 2012-05-30 MA MA34905A patent/MA33772B1/fr unknown
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EP2496556A1 (en) | 2012-09-12 |
ZA201202635B (en) | 2013-01-30 |
US9018383B2 (en) | 2015-04-28 |
US20120264790A1 (en) | 2012-10-18 |
CA2779268A1 (en) | 2011-05-05 |
JP5847088B2 (ja) | 2016-01-20 |
US8618304B2 (en) | 2013-12-31 |
IL219354A0 (en) | 2012-06-28 |
AR079022A1 (es) | 2011-12-21 |
UY32990A (es) | 2011-05-31 |
KR20120101429A (ko) | 2012-09-13 |
CN102858745A (zh) | 2013-01-02 |
MA33772B1 (fr) | 2012-11-01 |
TN2012000160A1 (en) | 2013-12-12 |
WO2011053948A1 (en) | 2011-05-05 |
CO6541540A2 (es) | 2012-10-16 |
MX2012004739A (es) | 2012-05-22 |
JP2013509446A (ja) | 2013-03-14 |
RU2012122805A (ru) | 2013-12-10 |
EP2496556B1 (en) | 2018-12-26 |
AU2010313162A1 (en) | 2012-05-24 |
PE20121477A1 (es) | 2012-11-14 |
US20140088158A1 (en) | 2014-03-27 |
DOP2012000121A (es) | 2012-07-31 |
TW201127379A (en) | 2011-08-16 |
CR20120203A (es) | 2012-06-01 |
BR112012010282A2 (pt) | 2016-03-29 |
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