ECSP12011861A - Derivados de ácido carboxílico cíclico sustituidos con acilamino y su uso como productos farmacéuticos - Google Patents

Derivados de ácido carboxílico cíclico sustituidos con acilamino y su uso como productos farmacéuticos

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Publication number
ECSP12011861A
ECSP12011861A ECSP12011861A ECSP12011861A EC SP12011861 A ECSP12011861 A EC SP12011861A EC SP12011861 A ECSP12011861 A EC SP12011861A EC SP12011861 A ECSP12011861 A EC SP12011861A
Authority
EC
Ecuador
Prior art keywords
acilamine
derivatives
carboxylic acid
pharmaceutical products
compounds
Prior art date
Application number
Other languages
English (en)
Inventor
Heinz-Werner Kleemann
Joseph Pernerstorfer
Marcel Patek
Alena Safarova
Matthias Schaefer
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42040612&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011861(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ECSP12011861A publication Critical patent/ECSP12011861A/es

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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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Abstract

La presente invención se refiere a compuestos de la fórmula I,en la que A, Y, Z, R20 a R22 y R50 tienen los significados indicados en las reivindicaciones, que son compuestos farmacéuticos activos valiosos. Específicamente, son inhibidores del receptor del gen de diferenciación endotelial 2 (Edg-2, EDG2), que se activa por el ácido lisofosfatídico (LPA) y también se denomina receptor LPA1, y son útiles para el tratamiento de enfermedades tales como aterosclerosis, infarto de miocardio e insuficiencia cardiaca, por ejemplo. La invención se refiere además a procedimientos para preparar los compuestos de la fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.
ECSP12011861 2009-11-02 2012-04-30 Derivados de ácido carboxílico cíclico sustituidos con acilamino y su uso como productos farmacéuticos ECSP12011861A (es)

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