EA201171066A1 - Новые замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина в качестве модуляторов гамма-секретазы - Google Patents

Новые замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина в качестве модуляторов гамма-секретазы

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Publication number
EA201171066A1
EA201171066A1 EA201171066A EA201171066A EA201171066A1 EA 201171066 A1 EA201171066 A1 EA 201171066A1 EA 201171066 A EA201171066 A EA 201171066A EA 201171066 A EA201171066 A EA 201171066A EA 201171066 A1 EA201171066 A1 EA 201171066A1
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EA
Eurasian Patent Office
Prior art keywords
benzimidazole
substituted derivatives
modulators
gamma
secretis
Prior art date
Application number
EA201171066A
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English (en)
Other versions
EA020141B1 (ru
Inventor
Хенрикус Якобус Мария Гейсен
Франсуа Поль Бишофф
Вэй Чжуан
Свен Францискус Анна Ван Брандт
Михел Суркин
Мирко Зая
Дидье Жан-Клод Бертело
Михел Анна Йозеф Де Клейн
Грегор Джеймс Макдональд
Дэниел Оельрих
Original Assignee
Орто-Макнейл-Янссен Фармасьютикалз, Инк.
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Application filed by Орто-Макнейл-Янссен Фармасьютикалз, Инк. filed Critical Орто-Макнейл-Янссен Фармасьютикалз, Инк.
Publication of EA201171066A1 publication Critical patent/EA201171066A1/ru
Publication of EA020141B1 publication Critical patent/EA020141B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к новым замещенным производным бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина формулы (I) , где R, R, R, R, X, А, А, А, А, Y, Y, Yи Z имеют указанные в формуле изобретения значения. Соединения согласно настоящему изобретению пригодны в качестве модуляторов гамма-секретазы. Изобретение, далее, относится к способам получения таких новых соединений, фармацевтическим композициям, включающим вышеуказанные соединения в качестве активного ингредиента, а также к применению вышеуказанных соединений в качестве лекарственного средства.
EA201171066A 2009-02-19 2010-02-15 Замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина в качестве модуляторов гамма-секретазы EA020141B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09153188 2009-02-19
EP09163409 2009-06-22
PCT/EP2010/051843 WO2010094647A1 (en) 2009-02-19 2010-02-15 Novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators

Publications (2)

Publication Number Publication Date
EA201171066A1 true EA201171066A1 (ru) 2012-04-30
EA020141B1 EA020141B1 (ru) 2014-08-29

Family

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Family Applications (1)

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EA201171066A EA020141B1 (ru) 2009-02-19 2010-02-15 Замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина в качестве модуляторов гамма-секретазы

Country Status (18)

Country Link
US (1) US8772504B2 (ru)
EP (1) EP2398793B1 (ru)
JP (1) JP5512705B2 (ru)
KR (1) KR20110124772A (ru)
CN (1) CN102341388B (ru)
AR (1) AR075520A1 (ru)
AU (1) AU2010215579B2 (ru)
BR (1) BRPI1016120A2 (ru)
CA (1) CA2749495A1 (ru)
EA (1) EA020141B1 (ru)
ES (1) ES2452881T3 (ru)
IL (1) IL214687A (ru)
MX (1) MX2011008754A (ru)
MY (1) MY151983A (ru)
SG (1) SG173668A1 (ru)
TW (1) TWI461425B (ru)
WO (1) WO2010094647A1 (ru)
ZA (1) ZA201106086B (ru)

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AR075520A1 (es) 2011-04-06
KR20110124772A (ko) 2011-11-17
MX2011008754A (es) 2011-09-09
IL214687A (en) 2015-01-29
MY151983A (en) 2014-07-31
US20120022090A1 (en) 2012-01-26
JP5512705B2 (ja) 2014-06-04
JP2012518024A (ja) 2012-08-09
EP2398793B1 (en) 2013-12-18
AU2010215579B2 (en) 2014-04-10
IL214687A0 (en) 2011-11-30
ES2452881T3 (es) 2014-04-03
CA2749495A1 (en) 2010-08-26
CN102341388A (zh) 2012-02-01
US8772504B2 (en) 2014-07-08
EP2398793A1 (en) 2011-12-28
EA020141B1 (ru) 2014-08-29
AU2010215579A1 (en) 2011-08-04
TWI461425B (zh) 2014-11-21
WO2010094647A1 (en) 2010-08-26
CN102341388B (zh) 2014-05-07
BRPI1016120A2 (pt) 2016-04-12
ZA201106086B (en) 2015-04-29
SG173668A1 (en) 2011-09-29
TW201040177A (en) 2010-11-16

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