MX2011008754A - Nuevos derivados sustituidos de benzoxazol, bencimidazol, oxazolopiridina e imidazopiridina como moduladores de gamma secretasa. - Google Patents

Nuevos derivados sustituidos de benzoxazol, bencimidazol, oxazolopiridina e imidazopiridina como moduladores de gamma secretasa.

Info

Publication number
MX2011008754A
MX2011008754A MX2011008754A MX2011008754A MX2011008754A MX 2011008754 A MX2011008754 A MX 2011008754A MX 2011008754 A MX2011008754 A MX 2011008754A MX 2011008754 A MX2011008754 A MX 2011008754A MX 2011008754 A MX2011008754 A MX 2011008754A
Authority
MX
Mexico
Prior art keywords
oxazolopyridine
benzimidazole
gamma secretase
novel substituted
secretase modulators
Prior art date
Application number
MX2011008754A
Other languages
English (en)
Inventor
Michel Surkyn
Henricus Jacobus Maria Gijsen
Sven Franciscus Anna Van Brandt
Francois Paul Bischoff
Gregor James Macdonald
Wei Zhuang
Didier Jean-Claude Berthelot
Mirko Zaja
Cleyn Michel Anna Jozef De
Daniel Oehlrich
Original Assignee
Ortho Mcneil Janssen Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Janssen Pharm filed Critical Ortho Mcneil Janssen Pharm
Publication of MX2011008754A publication Critical patent/MX2011008754A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a nuevos derivados sustituidos de benzoxazol, bencimidazol, oxazolopiridina e imidazopiridina de Fórmula (I) (ver fórmula (I)) en donde R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 y Z tienen el significado que se define en las reivindicaciones; los compuestos de acuerdo con la presente invención son útiles como moduladores de gamma secretasa; la invención se refiere además a procedimientos para preparar dichos compuestos nuevos, las composiciones farmacéuticas que comprenden a dichos compuestos como principio activo además del uso de dichos compuestos como medicamento.
MX2011008754A 2009-02-19 2010-02-15 Nuevos derivados sustituidos de benzoxazol, bencimidazol, oxazolopiridina e imidazopiridina como moduladores de gamma secretasa. MX2011008754A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09153188 2009-02-19
EP09163409 2009-06-22
PCT/EP2010/051843 WO2010094647A1 (en) 2009-02-19 2010-02-15 Novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators

Publications (1)

Publication Number Publication Date
MX2011008754A true MX2011008754A (es) 2011-09-09

Family

ID=42136263

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011008754A MX2011008754A (es) 2009-02-19 2010-02-15 Nuevos derivados sustituidos de benzoxazol, bencimidazol, oxazolopiridina e imidazopiridina como moduladores de gamma secretasa.

Country Status (18)

Country Link
US (1) US8772504B2 (es)
EP (1) EP2398793B1 (es)
JP (1) JP5512705B2 (es)
KR (1) KR20110124772A (es)
CN (1) CN102341388B (es)
AR (1) AR075520A1 (es)
AU (1) AU2010215579B2 (es)
BR (1) BRPI1016120A2 (es)
CA (1) CA2749495A1 (es)
EA (1) EA020141B1 (es)
ES (1) ES2452881T3 (es)
IL (1) IL214687A (es)
MX (1) MX2011008754A (es)
MY (1) MY151983A (es)
SG (1) SG173668A1 (es)
TW (1) TWI461425B (es)
WO (1) WO2010094647A1 (es)
ZA (1) ZA201106086B (es)

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Publication number Publication date
AR075520A1 (es) 2011-04-06
KR20110124772A (ko) 2011-11-17
IL214687A (en) 2015-01-29
MY151983A (en) 2014-07-31
US20120022090A1 (en) 2012-01-26
JP5512705B2 (ja) 2014-06-04
JP2012518024A (ja) 2012-08-09
EP2398793B1 (en) 2013-12-18
AU2010215579B2 (en) 2014-04-10
IL214687A0 (en) 2011-11-30
EA201171066A1 (ru) 2012-04-30
ES2452881T3 (es) 2014-04-03
CA2749495A1 (en) 2010-08-26
CN102341388A (zh) 2012-02-01
US8772504B2 (en) 2014-07-08
EP2398793A1 (en) 2011-12-28
EA020141B1 (ru) 2014-08-29
AU2010215579A1 (en) 2011-08-04
TWI461425B (zh) 2014-11-21
WO2010094647A1 (en) 2010-08-26
CN102341388B (zh) 2014-05-07
BRPI1016120A2 (pt) 2016-04-12
ZA201106086B (en) 2015-04-29
SG173668A1 (en) 2011-09-29
TW201040177A (en) 2010-11-16

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