MX355164B - Derivados de 3,4-dihidro-2h-pirido[1,2-a]pirazin-1,6-diona sustituidos utiles para el tratamiento de la enfermedad de alzheimer (inter alia). - Google Patents

Derivados de 3,4-dihidro-2h-pirido[1,2-a]pirazin-1,6-diona sustituidos utiles para el tratamiento de la enfermedad de alzheimer (inter alia).

Info

Publication number
MX355164B
MX355164B MX2014013957A MX2014013957A MX355164B MX 355164 B MX355164 B MX 355164B MX 2014013957 A MX2014013957 A MX 2014013957A MX 2014013957 A MX2014013957 A MX 2014013957A MX 355164 B MX355164 B MX 355164B
Authority
MX
Mexico
Prior art keywords
pyrido
pyrazine
dihydro
substituted
alzheimer
Prior art date
Application number
MX2014013957A
Other languages
English (en)
Other versions
MX2014013957A (es
Inventor
Roosbroeck Yves Emiel Maria Van
Frederik Jan Rita Rombouts
Andrés Avelino Trabanco-Suárez
De Diego Sergio-Alvar Alonso
Henricus Jacobus Maria Gijsen
Gregor James Macdonald
Francois Paul Bischoff
Adriana Ingrid Velter
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of MX2014013957A publication Critical patent/MX2014013957A/es
Publication of MX355164B publication Critical patent/MX355164B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a novedosos derivados de 3,4-dihidro-2H-pirido[1,2-a]pirazin-1,6-diona sustituidos de Fórmula (I) (ver Fórmula) donde R1, R2, R3, R4, R5, Z y X tienen el significado definido en las reivindicaciones; los compuestos de acuerdo con la presente invención son útiles como moduladores de la gamma-secretasa; la invención también se refiere a procesos para preparar tales compuestos novedosos, a composiciones farmacéuticas que comprenden dichos compuestos como principio activo, así como al uso de dichos compuestos como un medicamento.
MX2014013957A 2012-05-16 2013-05-16 Derivados de 3,4-dihidro-2h-pirido[1,2-a]pirazin-1,6-diona sustituidos utiles para el tratamiento de la enfermedad de alzheimer (inter alia). MX355164B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12168186 2012-05-16
EP12195875 2012-12-06
EP12197010 2012-12-13
EP13159178 2013-03-14
PCT/IB2013/054014 WO2013171712A1 (en) 2012-05-16 2013-05-16 Substituted 3, 4 - dihydro - 2h - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) alzheimer's disease

Publications (2)

Publication Number Publication Date
MX2014013957A MX2014013957A (es) 2015-02-12
MX355164B true MX355164B (es) 2018-04-06

Family

ID=48670031

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013957A MX355164B (es) 2012-05-16 2013-05-16 Derivados de 3,4-dihidro-2h-pirido[1,2-a]pirazin-1,6-diona sustituidos utiles para el tratamiento de la enfermedad de alzheimer (inter alia).

Country Status (15)

Country Link
US (1) US9181245B2 (es)
EP (1) EP2850083B1 (es)
JP (1) JP6106745B2 (es)
KR (1) KR102096625B1 (es)
CN (1) CN104583208B (es)
AU (1) AU2013261023B2 (es)
BR (1) BR112014028395B1 (es)
CA (1) CA2870347C (es)
EA (1) EA027242B1 (es)
ES (1) ES2585009T3 (es)
IL (1) IL235659A (es)
MX (1) MX355164B (es)
NZ (1) NZ702611A (es)
SG (1) SG11201407051XA (es)
WO (1) WO2013171712A1 (es)

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Also Published As

Publication number Publication date
KR20150009548A (ko) 2015-01-26
AU2013261023B2 (en) 2016-11-24
AU2013261023A1 (en) 2014-10-30
IL235659A0 (en) 2015-02-01
IL235659A (en) 2017-02-28
JP2015517517A (ja) 2015-06-22
ES2585009T3 (es) 2016-10-03
JP6106745B2 (ja) 2017-04-05
EA201492112A1 (ru) 2015-04-30
CA2870347C (en) 2020-08-04
CA2870347A1 (en) 2013-11-21
BR112014028395A2 (pt) 2017-06-27
MX2014013957A (es) 2015-02-12
KR102096625B1 (ko) 2020-04-03
US9181245B2 (en) 2015-11-10
US20150141411A1 (en) 2015-05-21
WO2013171712A1 (en) 2013-11-21
EP2850083A1 (en) 2015-03-25
SG11201407051XA (en) 2014-11-27
HK1207645A1 (en) 2016-02-05
EA027242B1 (ru) 2017-07-31
NZ702611A (en) 2016-10-28
CN104583208A (zh) 2015-04-29
BR112014028395B1 (pt) 2022-02-01
CN104583208B (zh) 2016-09-28
EP2850083B1 (en) 2016-04-27

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