UA108365C2 - Производные замещенного бициклического триазола как модуляторы гамма-секретазы - Google Patents

Производные замещенного бициклического триазола как модуляторы гамма-секретазы

Info

Publication number
UA108365C2
UA108365C2 UAA201207916A UAA201207916A UA108365C2 UA 108365 C2 UA108365 C2 UA 108365C2 UA A201207916 A UAA201207916 A UA A201207916A UA A201207916 A UAA201207916 A UA A201207916A UA 108365 C2 UA108365 C2 UA 108365C2
Authority
UA
Ukraine
Prior art keywords
triazole derivatives
modulators
gamma
sekretazy
compounds
Prior art date
Application number
UAA201207916A
Other languages
English (en)
Ukrainian (uk)
Inventor
Клейн Мішель Анна Джозеф де
Брандт Свен Франціскус Анна ван
Хенрікус Якобус Марія Гійсен
Дідьє Жан-Клод Берзелот
Деніел Оехлріч
Original Assignee
Янссен Фармасьютікелз, Інк
Селлзом Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармасьютікелз, Інк, Селлзом Лімітед filed Critical Янссен Фармасьютікелз, Інк
Priority claimed from PCT/EP2011/050349 external-priority patent/WO2011086098A1/en
Publication of UA108365C2 publication Critical patent/UA108365C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Настоящее изобретение относится к новым производным замещенного бициклические триазола формулы (I), где Het1, R1, R2, A1, A2, A3, A4, L1 и L2 имеют значения, определенные в пунктах формулы изобретения. Соединения по изобретению применяют как модуляторы гамма-секретазы. Изобретение также касается способов получения таких новых соединений, фармацевтических композиций, содержащих указанные соединения в качестве активного ингредиента, а также применение указанных соединений в качестве лекарственного средства.    (I) EMBED ISISServer (I)
UAA201207916A 2010-01-15 2011-01-12 Производные замещенного бициклического триазола как модуляторы гамма-секретазы UA108365C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10150892 2010-01-15
PCT/EP2011/050349 WO2011086098A1 (en) 2010-01-15 2011-01-12 Novel substituted bicyclic triazole derivatives as gamma secretase modulators

Publications (1)

Publication Number Publication Date
UA108365C2 true UA108365C2 (ru) 2015-04-27

Family

ID=42229172

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201207267A UA109776C2 (ru) 2010-01-15 2011-01-12 Замещенные триазольные производные как модуляторы гамма-секретазы
UAA201207916A UA108365C2 (ru) 2010-01-15 2011-01-12 Производные замещенного бициклического триазола как модуляторы гамма-секретазы

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA201207267A UA109776C2 (ru) 2010-01-15 2011-01-12 Замещенные триазольные производные как модуляторы гамма-секретазы

Country Status (1)

Country Link
UA (2) UA109776C2 (ru)

Also Published As

Publication number Publication date
UA109776C2 (ru) 2015-10-12

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