MX2012008259A - Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa. - Google Patents
Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa.Info
- Publication number
- MX2012008259A MX2012008259A MX2012008259A MX2012008259A MX2012008259A MX 2012008259 A MX2012008259 A MX 2012008259A MX 2012008259 A MX2012008259 A MX 2012008259A MX 2012008259 A MX2012008259 A MX 2012008259A MX 2012008259 A MX2012008259 A MX 2012008259A
- Authority
- MX
- Mexico
- Prior art keywords
- triazole derivatives
- gamma secretase
- substituted bicyclic
- novel substituted
- secretase modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
La presente invención se refiere a novedosos derivados bicíclicos de triazol sustituidos de Fórmula (I) (ver fórmula) donde Het1, R1, R2, A1, A2, A3, A4, L1 y L2 tienen el significado asignado en las reivindicaciones; los compuestos de conformidad con la presente invención son útiles como moduladores de gamma secretasa; la invención se refiere además a procesos para preparar dichos compuestos novedosos, composiciones farmacéuticas que comprenden dichos compuestos como ingrediente activo así como al uso de dichos compuestos como medicamento.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10150892 | 2010-01-15 | ||
EP10171292 | 2010-07-29 | ||
PCT/EP2011/050349 WO2011086098A1 (en) | 2010-01-15 | 2011-01-12 | Novel substituted bicyclic triazole derivatives as gamma secretase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012008259A true MX2012008259A (es) | 2012-08-17 |
Family
ID=43569255
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012008259A MX2012008259A (es) | 2010-01-15 | 2011-01-12 | Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa. |
MX2012008260A MX2012008260A (es) | 2010-01-15 | 2011-01-12 | Novedosos derivados de triazol sustituidos como moduladores de la gamma secretasa. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012008260A MX2012008260A (es) | 2010-01-15 | 2011-01-12 | Novedosos derivados de triazol sustituidos como moduladores de la gamma secretasa. |
Country Status (20)
Country | Link |
---|---|
US (2) | US9145399B2 (es) |
EP (2) | EP2523955B1 (es) |
JP (2) | JP5824464B2 (es) |
KR (2) | KR20130028048A (es) |
CN (2) | CN102803261A (es) |
AR (2) | AR079904A1 (es) |
AU (2) | AU2011206635B2 (es) |
BR (2) | BR112012017442A2 (es) |
CA (2) | CA2784765A1 (es) |
CL (2) | CL2012001955A1 (es) |
EA (2) | EA021776B1 (es) |
ES (2) | ES2512840T3 (es) |
IL (2) | IL220838A0 (es) |
MX (2) | MX2012008259A (es) |
NZ (2) | NZ601150A (es) |
PE (2) | PE20121512A1 (es) |
SG (2) | SG182506A1 (es) |
TW (2) | TWI473807B (es) |
WO (2) | WO2011086099A1 (es) |
ZA (2) | ZA201205240B (es) |
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KR20120050450A (ko) | 2009-07-15 | 2012-05-18 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체 |
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