EA201290655A1 - Новые производные замещенного бициклического триазола в качестве модуляторов гамма-секретазы - Google Patents

Новые производные замещенного бициклического триазола в качестве модуляторов гамма-секретазы

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Publication number
EA201290655A1
EA201290655A1 EA201290655A EA201290655A EA201290655A1 EA 201290655 A1 EA201290655 A1 EA 201290655A1 EA 201290655 A EA201290655 A EA 201290655A EA 201290655 A EA201290655 A EA 201290655A EA 201290655 A1 EA201290655 A1 EA 201290655A1
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EA
Eurasian Patent Office
Prior art keywords
gamma secretase
substituted bicyclic
new derivatives
compounds
secretase modulator
Prior art date
Application number
EA201290655A
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English (en)
Other versions
EA021776B1 (ru
Inventor
Михел Анна Йозеф Де Клейн
Свен Францискус Анна Ван Брандт
Хенрикус Якобус Мария Гейсен
Дидье Жан-Клод Бертело
Дэниел Оельрих
Original Assignee
Янссен Фармасьютикалз, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43569255&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201290655(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармасьютикалз, Инк. filed Critical Янссен Фармасьютикалз, Инк.
Publication of EA201290655A1 publication Critical patent/EA201290655A1/ru
Publication of EA021776B1 publication Critical patent/EA021776B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к новым производным замещенного бициклического триазола формулы (I), где Het, R, R, A, A, A, A, Lи Lимеют значения, определяемые в пунктах формулы изобретения. Соединения согласно настоящему изобретению применяют в качестве модуляторов гамма-секретазы. Изобретение также относится к способам получения таких новых соединений, фармацевтическим композициям, включающим указанные соединения в качестве активного ингредиента, а также к применению указанных соединений в качестве лекарственного средства.
EA201290655A 2010-01-15 2011-01-12 Новые производные замещенного бициклического триазола в качестве модуляторов гамма-секретазы EA021776B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10150892 2010-01-15
EP10171292 2010-07-29
PCT/EP2011/050349 WO2011086098A1 (en) 2010-01-15 2011-01-12 Novel substituted bicyclic triazole derivatives as gamma secretase modulators

Publications (2)

Publication Number Publication Date
EA201290655A1 true EA201290655A1 (ru) 2012-12-28
EA021776B1 EA021776B1 (ru) 2015-08-31

Family

ID=43569255

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201290655A EA021776B1 (ru) 2010-01-15 2011-01-12 Новые производные замещенного бициклического триазола в качестве модуляторов гамма-секретазы
EA201290654A EA022093B1 (ru) 2010-01-15 2011-01-12 Замещенные триазольные производные как модуляторы гамма-секретазы

Family Applications After (1)

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EA201290654A EA022093B1 (ru) 2010-01-15 2011-01-12 Замещенные триазольные производные как модуляторы гамма-секретазы

Country Status (20)

Country Link
US (2) US9145399B2 (ru)
EP (2) EP2523955B1 (ru)
JP (2) JP5824464B2 (ru)
KR (2) KR20130028048A (ru)
CN (2) CN102803261A (ru)
AR (2) AR079904A1 (ru)
AU (2) AU2011206635B2 (ru)
BR (2) BR112012017442A2 (ru)
CA (2) CA2784765A1 (ru)
CL (2) CL2012001955A1 (ru)
EA (2) EA021776B1 (ru)
ES (2) ES2512840T3 (ru)
IL (2) IL220838A0 (ru)
MX (2) MX2012008259A (ru)
NZ (2) NZ601150A (ru)
PE (2) PE20121512A1 (ru)
SG (2) SG182506A1 (ru)
TW (2) TWI473807B (ru)
WO (2) WO2011086099A1 (ru)
ZA (2) ZA201205240B (ru)

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