EA201590118A1 - Производные пирролидина и их применение в качестве модуляторов пути активации комплемента - Google Patents

Производные пирролидина и их применение в качестве модуляторов пути активации комплемента

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Publication number
EA201590118A1
EA201590118A1 EA201590118A EA201590118A EA201590118A1 EA 201590118 A1 EA201590118 A1 EA 201590118A1 EA 201590118 A EA201590118 A EA 201590118A EA 201590118 A EA201590118 A EA 201590118A EA 201590118 A1 EA201590118 A1 EA 201590118A1
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EA
Eurasian Patent Office
Prior art keywords
modulators
application
complement activation
pyrrolidine derivatives
present
Prior art date
Application number
EA201590118A
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English (en)
Inventor
Ульрих Хоммель
Эдвиж Лилиан Жанн Лортиуа
Юрген Клаус Майбаум
Нильс Остерманн
Штефан Андреас Рандль
Анна Вульпетти
Оливье Роже
Original Assignee
Новартис Аг
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Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201590118A1 publication Critical patent/EA201590118A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Настоящее изобретение обеспечивает соединение формулы (I)способ изготовления соединений изобретения и его терапевтическое применение. Настоящее изобретение дополнительно обеспечивает комбинацию фармакологически активных агентов и фармацевтическую композицию.
EA201590118A 2012-06-28 2013-06-27 Производные пирролидина и их применение в качестве модуляторов пути активации комплемента EA201590118A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261665477P 2012-06-28 2012-06-28
US201361774241P 2013-03-07 2013-03-07
PCT/IB2013/055299 WO2014002057A1 (en) 2012-06-28 2013-06-27 Pyrrolidine derivatives and their use as complement pathway modulators

Publications (1)

Publication Number Publication Date
EA201590118A1 true EA201590118A1 (ru) 2015-04-30

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EA201590118A EA201590118A1 (ru) 2012-06-28 2013-06-27 Производные пирролидина и их применение в качестве модуляторов пути активации комплемента

Country Status (11)

Country Link
US (1) US20150191462A1 (ru)
EP (1) EP2867222A1 (ru)
JP (1) JP2015522007A (ru)
KR (1) KR20150035766A (ru)
CN (1) CN104583193A (ru)
AU (1) AU2013282768A1 (ru)
BR (1) BR112014032734A2 (ru)
CA (1) CA2876993A1 (ru)
EA (1) EA201590118A1 (ru)
MX (1) MX2014015738A (ru)
WO (1) WO2014002057A1 (ru)

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CA2876993A1 (en) 2014-01-03
MX2014015738A (es) 2015-08-06
EP2867222A1 (en) 2015-05-06
WO2014002057A1 (en) 2014-01-03
KR20150035766A (ko) 2015-04-07
US20150191462A1 (en) 2015-07-09
JP2015522007A (ja) 2015-08-03
AU2013282768A1 (en) 2015-01-22
CN104583193A (zh) 2015-04-29
BR112014032734A2 (pt) 2017-06-27

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