EA201171008A1 - Новые замещенные бициклические гетероциклические соединения в качестве модуляторов гамма-секретазы - Google Patents

Новые замещенные бициклические гетероциклические соединения в качестве модуляторов гамма-секретазы

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Publication number
EA201171008A1
EA201171008A1 EA201171008A EA201171008A EA201171008A1 EA 201171008 A1 EA201171008 A1 EA 201171008A1 EA 201171008 A EA201171008 A EA 201171008A EA 201171008 A EA201171008 A EA 201171008A EA 201171008 A1 EA201171008 A1 EA 201171008A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
bicyclic heterocyclic
gamma secretase
substituted bicyclic
heterocyclic compounds
Prior art date
Application number
EA201171008A
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English (en)
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EA019685B1 (ru
Inventor
Хенрикус Якобус Мария Гейсен
Адриана Ингрид Велтер
Грегор Джеймс Макдональд
Франсуа Поль Бишофф
Тонгфей Ву
Свен Францискус Анна Ван Брандт
Михел Суркин
Мирко Зая
Серж Мария Алойсиус Питерс
Дидье Жан-Клод Бертело
Михел Анна Йозеф Де Клейн
Дэниел Оельрих
Original Assignee
Орто-Макнейл-Янссен Фармасьютикалз, Инк
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Application filed by Орто-Макнейл-Янссен Фармасьютикалз, Инк filed Critical Орто-Макнейл-Янссен Фармасьютикалз, Инк
Publication of EA201171008A1 publication Critical patent/EA201171008A1/ru
Publication of EA019685B1 publication Critical patent/EA019685B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Изобретение относится к замещенным бициклическим гетероциклическим соединениям формулы (I), где Het, Het, A, А, Аи Аимеют значения, указанные в формуле изобретения. Соединения согласно настоящему изобретению являются применимыми в качестве модуляторов гамма-секретазы. Изобретение далее относится к способам получения таких новых соединений, фармацевтическим композициям, содержащим указанные соединения в качестве активного ингредиента, а также применению указанных соединений в качестве лекарственных средств.
EA201171008A 2009-02-06 2010-02-02 Новые замещенные бициклические гетероциклические соединения в качестве модуляторов гамма-секретазы EA019685B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09152254 2009-02-06
PCT/EP2010/051244 WO2010089292A1 (en) 2009-02-06 2010-02-02 Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators

Publications (2)

Publication Number Publication Date
EA201171008A1 true EA201171008A1 (ru) 2012-02-28
EA019685B1 EA019685B1 (ru) 2014-05-30

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Family Applications (1)

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EA201171008A EA019685B1 (ru) 2009-02-06 2010-02-02 Новые замещенные бициклические гетероциклические соединения в качестве модуляторов гамма-секретазы

Country Status (20)

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US (2) US8946426B2 (ru)
EP (1) EP2393804B1 (ru)
JP (1) JP5576403B2 (ru)
KR (1) KR20110113197A (ru)
CN (1) CN102325765B (ru)
AP (1) AP2011005779A0 (ru)
AR (1) AR075366A1 (ru)
AU (1) AU2010211109B2 (ru)
BR (1) BRPI1008473A2 (ru)
CA (1) CA2748862A1 (ru)
EA (1) EA019685B1 (ru)
ES (1) ES2481715T3 (ru)
IL (1) IL214425A (ru)
MX (1) MX2011008335A (ru)
NZ (1) NZ593951A (ru)
SG (1) SG173510A1 (ru)
TW (1) TWI496780B (ru)
UA (1) UA106360C2 (ru)
WO (1) WO2010089292A1 (ru)
ZA (1) ZA201105788B (ru)

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MX2011008335A (es) 2011-09-06
JP5576403B2 (ja) 2014-08-20
EA019685B1 (ru) 2014-05-30
JP2012516870A (ja) 2012-07-26
AU2010211109B2 (en) 2014-11-27
AU2010211109A1 (en) 2011-07-21
US20110281881A1 (en) 2011-11-17
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US8946426B2 (en) 2015-02-03
EP2393804A1 (en) 2011-12-14
CN102325765A (zh) 2012-01-18
IL214425A0 (en) 2011-09-27
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WO2010089292A1 (en) 2010-08-12
CA2748862A1 (en) 2010-08-12
BRPI1008473A2 (pt) 2019-04-02
EP2393804B1 (en) 2014-04-16
KR20110113197A (ko) 2011-10-14
SG173510A1 (en) 2011-09-29
AP2011005779A0 (en) 2011-08-31
IL214425A (en) 2015-07-30
UA106360C2 (ru) 2014-08-26
ES2481715T3 (es) 2014-07-31
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