AP2011005779A0 - Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. - Google Patents
Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators.Info
- Publication number
- AP2011005779A0 AP2011005779A0 AP2011005779A AP2011005779A AP2011005779A0 AP 2011005779 A0 AP2011005779 A0 AP 2011005779A0 AP 2011005779 A AP2011005779 A AP 2011005779A AP 2011005779 A AP2011005779 A AP 2011005779A AP 2011005779 A0 AP2011005779 A0 AP 2011005779A0
- Authority
- AP
- ARIPO
- Prior art keywords
- compoundsas
- susbstituted
- novel
- bicyclic heterocyclic
- gamma secretase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09152254 | 2009-02-06 | ||
| PCT/EP2010/051244 WO2010089292A1 (en) | 2009-02-06 | 2010-02-02 | Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2011005779A0 true AP2011005779A0 (en) | 2011-08-31 |
Family
ID=40756688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2011005779A AP2011005779A0 (en) | 2009-02-06 | 2010-02-02 | Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8946426B2 (xx) |
| EP (1) | EP2393804B1 (xx) |
| JP (1) | JP5576403B2 (xx) |
| KR (1) | KR20110113197A (xx) |
| CN (1) | CN102325765B (xx) |
| AP (1) | AP2011005779A0 (xx) |
| AR (1) | AR075366A1 (xx) |
| AU (1) | AU2010211109B2 (xx) |
| BR (1) | BRPI1008473A2 (xx) |
| CA (1) | CA2748862A1 (xx) |
| EA (1) | EA019685B1 (xx) |
| ES (1) | ES2481715T3 (xx) |
| IL (1) | IL214425A (xx) |
| MX (1) | MX2011008335A (xx) |
| NZ (1) | NZ593951A (xx) |
| SG (1) | SG173510A1 (xx) |
| TW (1) | TWI496780B (xx) |
| UA (1) | UA106360C2 (xx) |
| WO (1) | WO2010089292A1 (xx) |
| ZA (1) | ZA201105788B (xx) |
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| PE20131197A1 (es) | 2008-10-31 | 2013-11-06 | Genentech Inc | Compuestos de pirazolopirimidina como inhibidores de jak y composiciones farmaceuticas que los contienen |
| BRPI0921317A2 (pt) | 2008-11-06 | 2017-06-06 | Astrazeneca Ab | composto, composição farmacêutica, e, método para tratar ou prevenir uma patologia relacionada com abeta em um mamífero |
| PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| AP2011005779A0 (en) | 2009-02-06 | 2011-08-31 | Ortho Mcneil Janssen Pharm | Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. |
| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| NZ596843A (en) | 2009-05-07 | 2012-12-21 | Janssen Pharmaceuticals Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
| UA110324C2 (xx) | 2009-07-02 | 2015-12-25 | Genentech Inc | Інгібуючі jak сполуки на основі піразолопіримідину |
| EP2454239B1 (en) | 2009-07-15 | 2014-08-13 | Janssen Pharmaceuticals Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
| BR112012017310A2 (pt) | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol substituídos como moduladores de gama secretase |
| CA2793024A1 (en) * | 2010-03-17 | 2011-09-22 | F. Hoffmann-La Roche Ag | Imidazopyridine compounds, compositions and methods of use |
| CN103209695A (zh) | 2010-09-15 | 2013-07-17 | 弗·哈夫曼-拉罗切有限公司 | 氮杂苯并噻唑化合物、组合物及应用方法 |
| EP2640722B1 (en) | 2010-11-19 | 2015-11-04 | F.Hoffmann-La Roche Ag | Pyrazolopyridines and their use as tyk2 inhibitors |
| KR20140047032A (ko) | 2011-03-24 | 2014-04-21 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조정제로서의 신규 치환 트리아졸릴 피페라진 및 트리아졸릴 피페리딘 유도체 |
| WO2012131539A1 (en) | 2011-03-31 | 2012-10-04 | Pfizer Inc. | Novel bicyclic pyridinones |
| IN2014MN00258A (xx) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc | |
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| AU2012325909B2 (en) | 2011-10-20 | 2016-06-09 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
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| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| CA2889249C (en) | 2012-12-20 | 2021-02-16 | Francois Paul Bischoff | Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
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| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
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| SI3145929T1 (sl) | 2014-05-23 | 2021-10-29 | Hoffmann La Roche | 5-kloro-2-difluorometoksifenil pirazolopirimidinove spojine, ki so zaviralci janusove kinaze |
| MX368391B (es) | 2015-02-03 | 2019-09-30 | Pfizer | Ciclopropabenzofuranil-piridopirazindionas novedosas. |
| MX2018015707A (es) | 2016-06-16 | 2019-03-21 | Janssen Pharmaceutica Nv | Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta. |
| EP3475279B1 (en) | 2016-06-27 | 2021-07-14 | F. Hoffmann-La Roche AG | Triazolopyridines as gamma-secretase modulators |
| MX2019004906A (es) | 2016-11-01 | 2019-06-20 | Nihon Nohyaku Co Ltd | Compuesto de quinolina que contiene un grupo oxima, n-oxido del mismo o su sal, insecticida agricola y horticola que comprende el compuesto, y metodo para utilizar el insecticida. |
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| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| CN102333777B (zh) | 2009-02-26 | 2014-06-25 | 卫材R&D管理有限公司 | 含氮的稠合杂环化合物及其作为β淀粉样蛋白生成抑制剂的用途 |
| JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
| US20120053165A1 (en) | 2009-03-03 | 2012-03-01 | Pfizer Inc. | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators |
| US20110299830A1 (en) | 2009-03-16 | 2011-12-08 | Panasonic Corporation | Application running device |
| EP2424866A1 (en) | 2009-04-27 | 2012-03-07 | High Point Pharmaceuticals, LLC | Substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions, and methods of use as -secretase inhibitors |
| NZ596843A (en) | 2009-05-07 | 2012-12-21 | Janssen Pharmaceuticals Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
| JP2010274429A (ja) | 2009-05-26 | 2010-12-09 | Ihi Corp | アライメントステージ |
| EP2454239B1 (en) | 2009-07-15 | 2014-08-13 | Janssen Pharmaceuticals Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
| BR112012017310A2 (pt) | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol substituídos como moduladores de gama secretase |
| KR20140047032A (ko) | 2011-03-24 | 2014-04-21 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조정제로서의 신규 치환 트리아졸릴 피페라진 및 트리아졸릴 피페리딘 유도체 |
| WO2012131539A1 (en) | 2011-03-31 | 2012-10-04 | Pfizer Inc. | Novel bicyclic pyridinones |
| IN2014MN00258A (xx) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc |
-
2010
- 2010-02-02 AP AP2011005779A patent/AP2011005779A0/xx unknown
- 2010-02-02 JP JP2011548663A patent/JP5576403B2/ja not_active Expired - Fee Related
- 2010-02-02 CA CA2748862A patent/CA2748862A1/en not_active Abandoned
- 2010-02-02 EP EP10701701.4A patent/EP2393804B1/en active Active
- 2010-02-02 US US13/144,554 patent/US8946426B2/en not_active Expired - Fee Related
- 2010-02-02 BR BRPI1008473-8A patent/BRPI1008473A2/pt not_active IP Right Cessation
- 2010-02-02 NZ NZ593951A patent/NZ593951A/xx not_active IP Right Cessation
- 2010-02-02 WO PCT/EP2010/051244 patent/WO2010089292A1/en active Application Filing
- 2010-02-02 CN CN201080007206.7A patent/CN102325765B/zh not_active Expired - Fee Related
- 2010-02-02 SG SG2011055746A patent/SG173510A1/en unknown
- 2010-02-02 EA EA201171008A patent/EA019685B1/ru not_active IP Right Cessation
- 2010-02-02 KR KR1020117020288A patent/KR20110113197A/ko not_active Application Discontinuation
- 2010-02-02 MX MX2011008335A patent/MX2011008335A/es active IP Right Grant
- 2010-02-02 ES ES10701701.4T patent/ES2481715T3/es active Active
- 2010-02-02 UA UAA201108162A patent/UA106360C2/ru unknown
- 2010-02-02 AU AU2010211109A patent/AU2010211109B2/en not_active Ceased
- 2010-02-05 TW TW099103416A patent/TWI496780B/zh not_active IP Right Cessation
- 2010-02-05 AR ARP100100325A patent/AR075366A1/es not_active Application Discontinuation
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2011
- 2011-08-03 IL IL214425A patent/IL214425A/en not_active IP Right Cessation
- 2011-08-05 ZA ZA2011/05788A patent/ZA201105788B/en unknown
-
2014
- 2014-12-01 US US14/556,845 patent/US20150094311A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2011008335A (es) | 2011-09-06 |
| AU2010211109B2 (en) | 2014-11-27 |
| NZ593951A (en) | 2013-01-25 |
| WO2010089292A1 (en) | 2010-08-12 |
| US20150094311A1 (en) | 2015-04-02 |
| IL214425A0 (en) | 2011-09-27 |
| JP2012516870A (ja) | 2012-07-26 |
| TW201040176A (en) | 2010-11-16 |
| ES2481715T3 (es) | 2014-07-31 |
| EP2393804B1 (en) | 2014-04-16 |
| EA201171008A1 (ru) | 2012-02-28 |
| US8946426B2 (en) | 2015-02-03 |
| EA019685B1 (ru) | 2014-05-30 |
| KR20110113197A (ko) | 2011-10-14 |
| AU2010211109A1 (en) | 2011-07-21 |
| US20110281881A1 (en) | 2011-11-17 |
| BRPI1008473A2 (pt) | 2019-04-02 |
| CA2748862A1 (en) | 2010-08-12 |
| CN102325765A (zh) | 2012-01-18 |
| ZA201105788B (en) | 2015-06-24 |
| SG173510A1 (en) | 2011-09-29 |
| UA106360C2 (ru) | 2014-08-26 |
| JP5576403B2 (ja) | 2014-08-20 |
| IL214425A (en) | 2015-07-30 |
| TWI496780B (zh) | 2015-08-21 |
| CN102325765B (zh) | 2014-12-24 |
| EP2393804A1 (en) | 2011-12-14 |
| AR075366A1 (es) | 2011-03-30 |
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