UA106360C2 - Замещенные бициклические гетероциклические соединения как модуляторы гамма-секретазы - Google Patents
Замещенные бициклические гетероциклические соединения как модуляторы гамма-секретазыInfo
- Publication number
- UA106360C2 UA106360C2 UAA201108162A UAA201108162A UA106360C2 UA 106360 C2 UA106360 C2 UA 106360C2 UA A201108162 A UAA201108162 A UA A201108162A UA A201108162 A UAA201108162 A UA A201108162A UA 106360 C2 UA106360 C2 UA 106360C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- bicyclic heterocyclic
- gamma secretase
- substituted bicyclic
- heterocyclic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Данное изобретение касается замещенных бициклических гетероциклических соединений формулы (I), где Het1, Het2, А1, А2, А3 и А4 имеют значения, указанные в формуле изобретения. Соединения, согласно данному изобретению, применяются в качестве модуляторов гамма-секретазы. Изобретение также касается способов получения таких новых соединений, фармацевтических композиций, содержащих указанные соединения в качестве активного ингредиента, а также применения указанных соединений в качестве лекарственных средств.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09152254 | 2009-02-06 | ||
PCT/EP2010/051244 WO2010089292A1 (en) | 2009-02-06 | 2010-02-02 | Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
UA106360C2 true UA106360C2 (ru) | 2014-08-26 |
Family
ID=40756688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201108162A UA106360C2 (ru) | 2009-02-06 | 2010-02-02 | Замещенные бициклические гетероциклические соединения как модуляторы гамма-секретазы |
Country Status (20)
Country | Link |
---|---|
US (2) | US8946426B2 (ru) |
EP (1) | EP2393804B1 (ru) |
JP (1) | JP5576403B2 (ru) |
KR (1) | KR20110113197A (ru) |
CN (1) | CN102325765B (ru) |
AP (1) | AP2011005779A0 (ru) |
AR (1) | AR075366A1 (ru) |
AU (1) | AU2010211109B2 (ru) |
BR (1) | BRPI1008473A2 (ru) |
CA (1) | CA2748862A1 (ru) |
EA (1) | EA019685B1 (ru) |
ES (1) | ES2481715T3 (ru) |
IL (1) | IL214425A (ru) |
MX (1) | MX2011008335A (ru) |
NZ (1) | NZ593951A (ru) |
SG (1) | SG173510A1 (ru) |
TW (1) | TWI496780B (ru) |
UA (1) | UA106360C2 (ru) |
WO (1) | WO2010089292A1 (ru) |
ZA (1) | ZA201105788B (ru) |
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-
2010
- 2010-02-02 NZ NZ593951A patent/NZ593951A/xx not_active IP Right Cessation
- 2010-02-02 CA CA2748862A patent/CA2748862A1/en not_active Abandoned
- 2010-02-02 KR KR1020117020288A patent/KR20110113197A/ko not_active Application Discontinuation
- 2010-02-02 SG SG2011055746A patent/SG173510A1/en unknown
- 2010-02-02 AU AU2010211109A patent/AU2010211109B2/en not_active Ceased
- 2010-02-02 CN CN201080007206.7A patent/CN102325765B/zh not_active Expired - Fee Related
- 2010-02-02 AP AP2011005779A patent/AP2011005779A0/xx unknown
- 2010-02-02 EA EA201171008A patent/EA019685B1/ru not_active IP Right Cessation
- 2010-02-02 WO PCT/EP2010/051244 patent/WO2010089292A1/en active Application Filing
- 2010-02-02 JP JP2011548663A patent/JP5576403B2/ja not_active Expired - Fee Related
- 2010-02-02 UA UAA201108162A patent/UA106360C2/ru unknown
- 2010-02-02 EP EP10701701.4A patent/EP2393804B1/en active Active
- 2010-02-02 BR BRPI1008473-8A patent/BRPI1008473A2/pt not_active IP Right Cessation
- 2010-02-02 ES ES10701701.4T patent/ES2481715T3/es active Active
- 2010-02-02 MX MX2011008335A patent/MX2011008335A/es active IP Right Grant
- 2010-02-02 US US13/144,554 patent/US8946426B2/en not_active Expired - Fee Related
- 2010-02-05 TW TW099103416A patent/TWI496780B/zh not_active IP Right Cessation
- 2010-02-05 AR ARP100100325A patent/AR075366A1/es not_active Application Discontinuation
-
2011
- 2011-08-03 IL IL214425A patent/IL214425A/en not_active IP Right Cessation
- 2011-08-05 ZA ZA2011/05788A patent/ZA201105788B/en unknown
-
2014
- 2014-12-01 US US14/556,845 patent/US20150094311A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ZA201105788B (en) | 2015-06-24 |
BRPI1008473A2 (pt) | 2019-04-02 |
SG173510A1 (en) | 2011-09-29 |
EP2393804B1 (en) | 2014-04-16 |
IL214425A (en) | 2015-07-30 |
EA201171008A1 (ru) | 2012-02-28 |
AU2010211109B2 (en) | 2014-11-27 |
AU2010211109A1 (en) | 2011-07-21 |
MX2011008335A (es) | 2011-09-06 |
JP2012516870A (ja) | 2012-07-26 |
JP5576403B2 (ja) | 2014-08-20 |
US20150094311A1 (en) | 2015-04-02 |
TW201040176A (en) | 2010-11-16 |
US20110281881A1 (en) | 2011-11-17 |
AR075366A1 (es) | 2011-03-30 |
NZ593951A (en) | 2013-01-25 |
CN102325765A (zh) | 2012-01-18 |
EP2393804A1 (en) | 2011-12-14 |
AP2011005779A0 (en) | 2011-08-31 |
CN102325765B (zh) | 2014-12-24 |
TWI496780B (zh) | 2015-08-21 |
KR20110113197A (ko) | 2011-10-14 |
US8946426B2 (en) | 2015-02-03 |
WO2010089292A1 (en) | 2010-08-12 |
IL214425A0 (en) | 2011-09-27 |
CA2748862A1 (en) | 2010-08-12 |
EA019685B1 (ru) | 2014-05-30 |
ES2481715T3 (es) | 2014-07-31 |
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