EA201201050A1 - Пиразолы в качестве антагонистов crth2 - Google Patents

Пиразолы в качестве антагонистов crth2

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Publication number
EA201201050A1
EA201201050A1 EA201201050A EA201201050A EA201201050A1 EA 201201050 A1 EA201201050 A1 EA 201201050A1 EA 201201050 A EA201201050 A EA 201201050A EA 201201050 A EA201201050 A EA 201201050A EA 201201050 A1 EA201201050 A1 EA 201201050A1
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EA
Eurasian Patent Office
Prior art keywords
pyrazoles
compounds
crth2
antagonists
antagonists crth2
Prior art date
Application number
EA201201050A
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English (en)
Other versions
EA022280B1 (ru
Inventor
Торстен Ост
Ральф Андерскевитц
Дитер Вольфганг Хампрехт
Кристоф Хёнке
Домник Мартирес
Вольфганг Рист
Петер Зайтер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42112128&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201201050(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201201050A1 publication Critical patent/EA201201050A1/ru
Publication of EA022280B1 publication Critical patent/EA022280B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Organic Chemistry (AREA)
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Abstract

Настоящее изобретение относится к пиразолам формулы (I) и их фармацевтически приемлемым солям, обладающим активностью в отношении CRTH2, где значения W, L, L, X, L, Y, Rи Rявляются такими, как определено в описании и формуле изобретения, к применению указанных соединений в качестве лекарственных средств и к фармацевтическим составам, содержащим указанные соединения или содержащим комбинацию указанных соединений с одним или более активных веществ.
EA201201050A 2010-01-27 2011-01-24 Пиразолы в качестве антагонистов crth2 EA022280B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10151785 2010-01-27
PCT/EP2011/050910 WO2011092140A1 (en) 2010-01-27 2011-01-24 Pyrazole compounds as crth2 antagonists

Publications (2)

Publication Number Publication Date
EA201201050A1 true EA201201050A1 (ru) 2013-02-28
EA022280B1 EA022280B1 (ru) 2015-12-30

Family

ID=42112128

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201050A EA022280B1 (ru) 2010-01-27 2011-01-24 Пиразолы в качестве антагонистов crth2

Country Status (37)

Country Link
US (1) US8791272B2 (ru)
EP (1) EP2528901B9 (ru)
JP (1) JP5658284B2 (ru)
KR (2) KR101906791B1 (ru)
CN (3) CN104829535A (ru)
AP (1) AP3360A (ru)
AR (1) AR080032A1 (ru)
AU (1) AU2011209286B2 (ru)
BR (1) BR112012018695A2 (ru)
CA (1) CA2788224C (ru)
CL (1) CL2012001836A1 (ru)
CO (1) CO6511272A2 (ru)
CY (1) CY1116641T1 (ru)
DK (1) DK2528901T3 (ru)
EA (1) EA022280B1 (ru)
ES (1) ES2545865T3 (ru)
GE (1) GEP20146177B (ru)
HK (1) HK1176062A1 (ru)
HR (1) HRP20150898T1 (ru)
HU (1) HUE025318T2 (ru)
IL (1) IL220208A (ru)
MA (1) MA33937B1 (ru)
MX (1) MX353000B (ru)
MY (1) MY160036A (ru)
NZ (1) NZ600637A (ru)
PE (1) PE20121519A1 (ru)
PL (1) PL2528901T3 (ru)
PT (1) PT2528901E (ru)
RS (1) RS54176B1 (ru)
SG (1) SG182684A1 (ru)
SI (1) SI2528901T1 (ru)
TN (1) TN2012000371A1 (ru)
TW (1) TWI499416B (ru)
UA (1) UA110025C2 (ru)
UY (1) UY33201A (ru)
WO (1) WO2011092140A1 (ru)
ZA (1) ZA201204335B (ru)

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CN103113303A (zh) * 2011-11-16 2013-05-22 山东亨利医药科技有限责任公司 作为crth2受体拮抗剂的氮杂环化合物
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AU2012362724C1 (en) * 2011-12-27 2018-01-18 Allergan, Inc. Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response
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US20140148484A1 (en) * 2012-11-23 2014-05-29 Boehringer Ingelheim International Gmbh Pyrazole compounds for treating hairloss
WO2014138979A1 (en) 2013-03-13 2014-09-18 Canadian Blood Services Pyrazole derivatives and their uses thereof
CN103265537B (zh) * 2013-05-14 2015-05-27 浙江医药高等专科学校 抗肿瘤化合物、其制备方法和用途
CN103265535B (zh) * 2013-05-14 2015-06-17 浙江医药高等专科学校 抗肿瘤化合物、其制备方法和用途
AU2015308350B2 (en) 2014-08-29 2020-03-05 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
LT3762368T (lt) 2018-03-08 2022-06-10 Incyte Corporation Aminopirazindiolio junginiai, kaip pi3k-γ inhibitoriai
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
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CR20210605A (es) 2019-06-06 2022-01-07 Basf Se N-(prid-3-il)carboxamidas fungicidas
WO2021063735A1 (en) 2019-10-02 2021-04-08 Basf Se New bicyclic pyridine derivatives

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