BR112014028395A2 - derivados 3,4-di-hidro-2h-pirido[1,2-a] pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer - Google Patents

derivados 3,4-di-hidro-2h-pirido[1,2-a] pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer

Info

Publication number
BR112014028395A2
BR112014028395A2 BR112014028395A BR112014028395A BR112014028395A2 BR 112014028395 A2 BR112014028395 A2 BR 112014028395A2 BR 112014028395 A BR112014028395 A BR 112014028395A BR 112014028395 A BR112014028395 A BR 112014028395A BR 112014028395 A2 BR112014028395 A2 BR 112014028395A2
Authority
BR
Brazil
Prior art keywords
pyrido
pyrazine
alzheimer
dihydro
disease
Prior art date
Application number
BR112014028395A
Other languages
English (en)
Other versions
BR112014028395B1 (pt
Inventor
Ingrid Velter Adriana
Avelino Trabanco-Suárez Andrés
Paul Bischoff François
Jan Rita Rombouts Frederik
James Macdonald Gregor
Jacobus Maria Gijsen Henricus
Alonso-De Diego Sergio-Alvar
Emiel Maria Van Roosbroeck Yves
Original Assignee
Cellzome Ltd
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ltd, Janssen Pharmaceuticals Inc filed Critical Cellzome Ltd
Publication of BR112014028395A2 publication Critical patent/BR112014028395A2/pt
Publication of BR112014028395B1 publication Critical patent/BR112014028395B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
BR112014028395-8A 2012-05-16 2013-05-16 Derivados 3,4-di-hidro-2h-pirido[1,2-a]pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer e composição farmacêutica que os compreende BR112014028395B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP12168186 2012-05-16
EP12168186.0 2012-05-16
EP12195875 2012-12-06
EP12195875.5 2012-12-06
EP12197010.7 2012-12-13
EP12197010 2012-12-13
EP13159178.6 2013-03-14
EP13159178 2013-03-14
PCT/IB2013/054014 WO2013171712A1 (en) 2012-05-16 2013-05-16 Substituted 3, 4 - dihydro - 2h - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) alzheimer's disease

Publications (2)

Publication Number Publication Date
BR112014028395A2 true BR112014028395A2 (pt) 2017-06-27
BR112014028395B1 BR112014028395B1 (pt) 2022-02-01

Family

ID=48670031

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014028395-8A BR112014028395B1 (pt) 2012-05-16 2013-05-16 Derivados 3,4-di-hidro-2h-pirido[1,2-a]pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer e composição farmacêutica que os compreende

Country Status (16)

Country Link
US (1) US9181245B2 (pt)
EP (1) EP2850083B1 (pt)
JP (1) JP6106745B2 (pt)
KR (1) KR102096625B1 (pt)
CN (1) CN104583208B (pt)
AU (1) AU2013261023B2 (pt)
BR (1) BR112014028395B1 (pt)
CA (1) CA2870347C (pt)
EA (1) EA027242B1 (pt)
ES (1) ES2585009T3 (pt)
HK (1) HK1207645A1 (pt)
IL (1) IL235659A (pt)
MX (1) MX355164B (pt)
NZ (1) NZ702611A (pt)
SG (1) SG11201407051XA (pt)
WO (1) WO2013171712A1 (pt)

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Also Published As

Publication number Publication date
AU2013261023B2 (en) 2016-11-24
JP6106745B2 (ja) 2017-04-05
HK1207645A1 (en) 2016-02-05
IL235659A0 (en) 2015-02-01
JP2015517517A (ja) 2015-06-22
CA2870347C (en) 2020-08-04
EA201492112A1 (ru) 2015-04-30
CA2870347A1 (en) 2013-11-21
EP2850083B1 (en) 2016-04-27
IL235659A (en) 2017-02-28
CN104583208A (zh) 2015-04-29
KR20150009548A (ko) 2015-01-26
BR112014028395B1 (pt) 2022-02-01
EP2850083A1 (en) 2015-03-25
KR102096625B1 (ko) 2020-04-03
EA027242B1 (ru) 2017-07-31
AU2013261023A1 (en) 2014-10-30
WO2013171712A1 (en) 2013-11-21
NZ702611A (en) 2016-10-28
SG11201407051XA (en) 2014-11-27
MX2014013957A (es) 2015-02-12
MX355164B (es) 2018-04-06
CN104583208B (zh) 2016-09-28
US20150141411A1 (en) 2015-05-21
ES2585009T3 (es) 2016-10-03
US9181245B2 (en) 2015-11-10

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