MX2011011303A - Derivados de isoxazol. - Google Patents
Derivados de isoxazol.Info
- Publication number
- MX2011011303A MX2011011303A MX2011011303A MX2011011303A MX2011011303A MX 2011011303 A MX2011011303 A MX 2011011303A MX 2011011303 A MX2011011303 A MX 2011011303A MX 2011011303 A MX2011011303 A MX 2011011303A MX 2011011303 A MX2011011303 A MX 2011011303A
- Authority
- MX
- Mexico
- Prior art keywords
- present
- isoxazole derivatives
- concerned
- formula
- active compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
La presente invención se refiere a nuevos derivados de isoxazol de la fórmula I (ver fórmula (I)) en la que X, R1, R2, R3, R4 y R5 tienen los significados aquí definidos, así como sus sales y ésteres farmacéuticamente aceptables. Los compuestos activos de la presente invención tienen afinidad y selectividad para con el receptor de GABA A a5. La presente invención se refiere además a la obtención de los compuestos activos de la fórmula I, la fabricación de composiciones farmacéuticas que los contienen y su utilización como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09159150 | 2009-04-30 | ||
PCT/EP2010/055591 WO2010125042A1 (en) | 2009-04-30 | 2010-04-27 | Isoxazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011011303A true MX2011011303A (es) | 2011-11-18 |
Family
ID=42229188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011011303A MX2011011303A (es) | 2009-04-30 | 2010-04-27 | Derivados de isoxazol. |
Country Status (15)
Country | Link |
---|---|
US (2) | US8227461B2 (es) |
EP (1) | EP2424863B1 (es) |
JP (1) | JP5478714B2 (es) |
KR (1) | KR101438261B1 (es) |
CN (1) | CN102395583B (es) |
AR (1) | AR077534A1 (es) |
AU (1) | AU2010243652B2 (es) |
BR (1) | BRPI1016192A8 (es) |
CA (1) | CA2750678C (es) |
ES (1) | ES2431389T3 (es) |
IL (1) | IL214251A0 (es) |
MX (1) | MX2011011303A (es) |
SG (1) | SG175316A1 (es) |
TW (1) | TW201043621A (es) |
WO (1) | WO2010125042A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101889010B (zh) * | 2007-12-04 | 2012-12-05 | 弗·哈夫曼-拉罗切有限公司 | 异*唑-吡啶衍生物 |
SG175780A1 (en) * | 2009-05-05 | 2011-12-29 | Hoffmann La Roche | Isoxazole-pyridazine derivatives |
RU2563167C2 (ru) * | 2010-11-05 | 2015-09-20 | Ф. Хоффманн-Ля Рош Аг | Применение активных фармацевтических соединений для лечения заболеваний центральной нервной системы |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
IN2014DN11027A (es) | 2012-06-26 | 2015-09-25 | Aniona Aps | |
WO2014001280A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
WO2014001278A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
WO2014001279A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
CN104411699B (zh) | 2012-06-26 | 2017-06-13 | 萨尼奥纳有限责任公司 | 苯基三唑衍生物及其用于调节gabaa 受体复合体的用途 |
BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3525205A1 (de) * | 1984-09-11 | 1986-03-20 | Hoechst Ag, 6230 Frankfurt | Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols |
GB9808663D0 (en) | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic agents |
US6660753B2 (en) | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
IT1314191B1 (it) | 1999-10-18 | 2002-12-06 | Recordati Chem Pharm | Derivati isossazolcarbossamidici |
BR0015420A (pt) | 1999-11-12 | 2002-07-16 | Neurogen Corp | Composto, composição farmacêutica, métodos de tratamento de uma doença ou de um distúrbio associados com agonismo patogênio, para a localização de receptores gabaa, em uma amostra de tecido, de inibição da ligação de um composto de benzodiazepina em um receptor gabaa, e de alteração da atividade de transdução de sinal de receptores gabaa, agonismo inverso ou antagonismo do receptor gabaa, uso de um composto, e , composição faramcêutica embalada |
PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
GB0108475D0 (en) | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
PL366624A1 (en) | 2001-07-05 | 2005-02-07 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as mch selective antagonists |
DE60131967D1 (de) | 2001-08-13 | 2008-01-31 | Phenex Pharmaceuticals Ag | Nr1h4-kern-rezeptor-bindende verbindungen |
DE60225174T2 (de) | 2001-11-20 | 2009-02-12 | Eli Lilly And Co., Indianapolis | Beta-3 adrenergische agonisten |
GB0128160D0 (en) | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Novel compounds |
JP2006515838A (ja) | 2002-11-22 | 2006-06-08 | スミスクライン ビーチャム コーポレーション | ファルネソイドx受容体アゴニスト |
GB0318447D0 (en) | 2003-08-05 | 2003-09-10 | Merck Sharp & Dohme | Therapeutic agents |
RS50603B (sr) | 2004-06-01 | 2010-05-07 | F. Hoffmann-La Roche Ag. | Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora |
WO2005123672A2 (en) | 2004-06-14 | 2005-12-29 | Takeda San Diego, Inc. | Kinase inhibitors |
BRPI0516842A (pt) | 2004-10-01 | 2008-09-23 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por lxr alfa e/ou lxr beta agonistas e uso desses compostos |
EP1812427A4 (en) | 2004-10-15 | 2009-10-14 | Scripps Research Inst | FATTY ACID AMIDE HYDROLASE OXADIAZOLE KETONE INHIBITORS |
US20070060589A1 (en) | 2004-12-21 | 2007-03-15 | Purandare Ashok V | Inhibitors of protein arginine methyl transferases |
EP1904337B1 (de) | 2005-07-20 | 2010-10-13 | Prospective Concepts AG | Pneumatisch verstellbare seitenwangen für fahrzeugsitze |
DE602006003777D1 (de) | 2005-09-19 | 2009-01-02 | Hoffmann La Roche | Isoxazolderivate als inverse gaba a alpha5 agonisten |
WO2007052843A1 (ja) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
ATE526318T1 (de) | 2005-12-19 | 2011-10-15 | Glaxosmithkline Llc | Farnesoid-x-rezeptor-agonisten |
WO2007092751A2 (en) | 2006-02-03 | 2007-08-16 | Eli Lilly And Company | Compounds and methods for modulating fx-receptors |
JP2007230909A (ja) | 2006-03-01 | 2007-09-13 | Univ Of Tokyo | 置換イソキサゾール誘導体 |
WO2007137954A1 (en) * | 2006-05-31 | 2007-12-06 | F. Hoffmann-La Roche Ag | Aryl-4-ethynyl-isoxazole derivatives |
EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
US7943653B2 (en) * | 2007-08-13 | 2011-05-17 | Janssen Pharmaceutica N.V. | Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators |
US7943619B2 (en) * | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
CN101889010B (zh) | 2007-12-04 | 2012-12-05 | 弗·哈夫曼-拉罗切有限公司 | 异*唑-吡啶衍生物 |
EP2229383B1 (en) * | 2007-12-04 | 2017-01-18 | F. Hoffmann-La Roche AG | Isoxazolo-pyrazine derivatives |
SG175780A1 (en) * | 2009-05-05 | 2011-12-29 | Hoffmann La Roche | Isoxazole-pyridazine derivatives |
SG175318A1 (en) * | 2009-05-07 | 2011-11-28 | Hoffmann La Roche | Isoxazole-pyridine derivatives as gaba modulators |
-
2010
- 2010-04-23 US US12/766,202 patent/US8227461B2/en active Active
- 2010-04-23 US US12/766,125 patent/US20100280019A1/en not_active Abandoned
- 2010-04-27 ES ES10715840T patent/ES2431389T3/es active Active
- 2010-04-27 WO PCT/EP2010/055591 patent/WO2010125042A1/en active Application Filing
- 2010-04-27 CN CN201080016615.3A patent/CN102395583B/zh not_active Expired - Fee Related
- 2010-04-27 MX MX2011011303A patent/MX2011011303A/es active IP Right Grant
- 2010-04-27 TW TW099113368A patent/TW201043621A/zh unknown
- 2010-04-27 EP EP10715840.4A patent/EP2424863B1/en not_active Not-in-force
- 2010-04-27 SG SG2011077500A patent/SG175316A1/en unknown
- 2010-04-27 JP JP2012506532A patent/JP5478714B2/ja active Active
- 2010-04-27 BR BRPI1016192A patent/BRPI1016192A8/pt not_active Application Discontinuation
- 2010-04-27 AU AU2010243652A patent/AU2010243652B2/en not_active Expired - Fee Related
- 2010-04-27 CA CA2750678A patent/CA2750678C/en not_active Expired - Fee Related
- 2010-04-27 KR KR1020117025276A patent/KR101438261B1/ko not_active IP Right Cessation
- 2010-04-29 AR ARP100101438A patent/AR077534A1/es not_active Application Discontinuation
-
2011
- 2011-07-21 IL IL214251A patent/IL214251A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2424863A1 (en) | 2012-03-07 |
CN102395583A (zh) | 2012-03-28 |
SG175316A1 (en) | 2011-12-29 |
WO2010125042A1 (en) | 2010-11-04 |
US20100280020A1 (en) | 2010-11-04 |
EP2424863B1 (en) | 2013-09-18 |
JP5478714B2 (ja) | 2014-04-23 |
BRPI1016192A2 (pt) | 2016-04-19 |
KR101438261B1 (ko) | 2014-09-05 |
AR077534A1 (es) | 2011-09-07 |
AU2010243652A1 (en) | 2011-09-15 |
ES2431389T3 (es) | 2013-11-26 |
US8227461B2 (en) | 2012-07-24 |
TW201043621A (en) | 2010-12-16 |
KR20120016069A (ko) | 2012-02-22 |
IL214251A0 (en) | 2011-09-27 |
BRPI1016192A8 (pt) | 2017-10-10 |
US20100280019A1 (en) | 2010-11-04 |
CN102395583B (zh) | 2015-04-01 |
JP2012524762A (ja) | 2012-10-18 |
CA2750678C (en) | 2014-11-04 |
AU2010243652B2 (en) | 2013-02-07 |
CA2750678A1 (en) | 2010-11-04 |
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Legal Events
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