DOP2012000225A - Compuestos de pirrolo-pirimidina como inhibidores de cdk4/6 - Google Patents

Compuestos de pirrolo-pirimidina como inhibidores de cdk4/6

Info

Publication number
DOP2012000225A
DOP2012000225A DO2012000225A DO2012000225A DOP2012000225A DO P2012000225 A DOP2012000225 A DO P2012000225A DO 2012000225 A DO2012000225 A DO 2012000225A DO 2012000225 A DO2012000225 A DO 2012000225A DO P2012000225 A DOP2012000225 A DO P2012000225A
Authority
DO
Dominican Republic
Prior art keywords
cdk4
pirrolo
inhibitors
cancer
pyrimidine compounds
Prior art date
Application number
DO2012000225A
Other languages
English (en)
Inventor
Lawrence Blas Perez
Young Shin Cho
Christopher Thomas Brain
John William Giraldes
Bharat Lagu
Julian Levell
Michael LUZZIO
Yaping Wang
Fan Yang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of DOP2012000225A publication Critical patent/DOP2012000225A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

LA INVENCIÓN SE REFIERE A NOVEDOSOS COMPUESTOS DE PIRROLO-PIRIMIDINA DE LA FÓRMULA (I): EN DONDE R1, R2Y, R4, R8- R11, A Y L SE DEFINEN EN LA PRESENTE, Y A LAS SALES, INCLUYENDO LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS DE LA PRESENTE INVENCIÓN SON INHIBIDORES DE CDK4/6 Y PODRÍAN SER ÚTILES EN EL TRATAMIENTO DE LAS ENFERMEDADES Y LOS TRASTORNOS MEDIADOS POR CDK4/6, TALES COMO CÁNCER, INCLUYENDO LINFOMA DE CÉLULAS DE MANTO, LIPOSARCOMA, CÁNCER PULMONAR NO MICROCELULAR, MELANOMA, CÁNCER ESOFÁGICO DE CÉLULAS ESCAMOSAS, Y CÁNCER DE MAMA. LA INVENCIÓN SE REFIERE ADEMÁS A LAS COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN UN COMPUESTO DE LA INVENCIÓN. LA INVENCIÓN SE REFIERE TODAVÍA ADICIONALMENTE A LOS PROCEDIMIENTOS PARA LA FABRICACIÓN DE UN MEDICAMENTO ÚTIL PARA INHIBIR LA ACTIVIDAD DE CDK4/6, Y AL TRATAMIENTO DE LOS TRASTORNOS ASOCIADOS CON LA MISMA, UTILIZANDO UN COMPUESTO DE LA INVENCIÓN O UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDA UN COMPUESTO DE LA INVENCIÓN.
DO2012000225A 2010-02-19 2012-08-17 Compuestos de pirrolo-pirimidina como inhibidores de cdk4/6 DOP2012000225A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30624810P 2010-02-19 2010-02-19
US201161429372P 2011-01-03 2011-01-03
US201161429997P 2011-01-05 2011-01-05

Publications (1)

Publication Number Publication Date
DOP2012000225A true DOP2012000225A (es) 2013-01-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DO2012000225A DOP2012000225A (es) 2010-02-19 2012-08-17 Compuestos de pirrolo-pirimidina como inhibidores de cdk4/6

Country Status (38)

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US (2) US8957074B2 (es)
EP (1) EP2536730B1 (es)
JP (1) JP5788415B2 (es)
KR (1) KR101812357B1 (es)
CN (1) CN102918043B (es)
AR (1) AR080198A1 (es)
AU (1) AU2011217286B2 (es)
BR (1) BR112012020922B1 (es)
CA (1) CA2790637C (es)
CL (1) CL2012002270A1 (es)
DK (1) DK2536730T3 (es)
DO (1) DOP2012000225A (es)
EA (1) EA022355B1 (es)
EC (1) ECSP12012111A (es)
ES (1) ES2548532T3 (es)
GE (1) GEP20146146B (es)
HK (1) HK1176616A1 (es)
HN (1) HN2012001744A (es)
HR (1) HRP20151071T1 (es)
IL (1) IL221520A (es)
MA (1) MA34066B1 (es)
ME (1) ME02202B (es)
MX (1) MX2012009613A (es)
NI (1) NI201200135A (es)
NZ (1) NZ601754A (es)
PE (1) PE20121815A1 (es)
PL (1) PL2536730T3 (es)
PT (1) PT2536730E (es)
RS (1) RS54263B1 (es)
SG (1) SG183218A1 (es)
SI (1) SI2536730T1 (es)
SM (1) SMT201500265B (es)
TN (1) TN2012000413A1 (es)
TW (1) TWI503322B (es)
UA (1) UA108369C2 (es)
UY (1) UY33227A (es)
WO (1) WO2011101409A1 (es)
ZA (1) ZA201206079B (es)

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