PE20210121A1 - Regimenes de dosificacion superior de g1t38 - Google Patents
Regimenes de dosificacion superior de g1t38Info
- Publication number
- PE20210121A1 PE20210121A1 PE2020000908A PE2020000908A PE20210121A1 PE 20210121 A1 PE20210121 A1 PE 20210121A1 PE 2020000908 A PE2020000908 A PE 2020000908A PE 2020000908 A PE2020000908 A PE 2020000908A PE 20210121 A1 PE20210121 A1 PE 20210121A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se refiere a un regimen de dosificacion para la administracion del inhibidor selectivo de CDK4/6 conocido como G1T38, que es 2'-((5-(4-isopropilpiperazin-1-il)piridin-2-il)amino)-7',8'-dihidro-6'H-espiro[ciclohexano-1,9'-pirazino[1',2':1,5]pirrolo[2,3-d]pirimidin]-6'-ona o una sal farmaceuticamente aceptable del mismo y se emplea en el tratamiento de diversos tipos de cancer. Este regimen de dosificacion suministra: a) un regimen de dosificacion solido de G1T38 para el suministro oral que proporciona una relacion de (AUC(0-24ss) media en estado estacionario (h ng/mL))/dosis (mg) no mayor que 5 y/o b) un regimen de dosificacion solido de G1T38 para el suministro oral que en el dia 22 despues de la primera dosis proporciona una relacion AUC (0-24ss) media en estado estacionario (h ng/mL)/recuento absoluto de neutrofilos (celulas/mm3) no mayor que 1,25.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862614952P | 2018-01-08 | 2018-01-08 | |
US201862679575P | 2018-06-01 | 2018-06-01 | |
US201962788017P | 2019-01-03 | 2019-01-03 | |
PCT/US2019/012720 WO2019136451A1 (en) | 2018-01-08 | 2019-01-08 | G1t38 superior dosage regimes |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20210121A1 true PE20210121A1 (es) | 2021-01-19 |
Family
ID=67143921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2020000908A PE20210121A1 (es) | 2018-01-08 | 2019-01-08 | Regimenes de dosificacion superior de g1t38 |
Country Status (16)
Country | Link |
---|---|
US (2) | US11357779B2 (es) |
EP (1) | EP3738084A4 (es) |
JP (1) | JP2021509680A (es) |
KR (1) | KR20200108867A (es) |
CN (1) | CN111837146A (es) |
AU (1) | AU2019205821A1 (es) |
BR (1) | BR112020013915A2 (es) |
CA (1) | CA3087570A1 (es) |
CO (1) | CO2020008825A2 (es) |
IL (1) | IL275708A (es) |
MX (1) | MX2020007312A (es) |
PE (1) | PE20210121A1 (es) |
PH (1) | PH12020551050A1 (es) |
RU (1) | RU2020123665A (es) |
SG (1) | SG11202005937QA (es) |
WO (1) | WO2019136451A1 (es) |
Families Citing this family (7)
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ME03557B (me) * | 2013-03-15 | 2020-07-20 | G1 Therapeutics Inc | Privremena zaštiтa normalnih ćelija током hemoterapije |
BR112019013814A2 (pt) | 2017-01-06 | 2020-01-21 | G1 Therapeutics Inc | método para tratamento de câncer ou de um tumor em um indivíduo, composição farmacêutica, combinação, e, kit. |
AU2019253706A1 (en) * | 2018-04-09 | 2020-11-26 | G1 Therapeutics, Inc. | Treatment of cancers having driving oncogenic mutations |
TW202128174A (zh) * | 2019-10-09 | 2021-08-01 | 美商G1治療公司 | 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療 |
AU2021273744A1 (en) | 2020-05-19 | 2022-12-08 | G1 Therapeutics, Inc. | Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders |
JP2023537595A (ja) * | 2020-08-13 | 2023-09-04 | ファイザー・インク | 併用治療 |
EP4308123A1 (en) * | 2021-03-17 | 2024-01-24 | Amgen Inc. | Sotorasib dosing regimen |
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2019
- 2019-01-08 JP JP2020537622A patent/JP2021509680A/ja active Pending
- 2019-01-08 RU RU2020123665A patent/RU2020123665A/ru unknown
- 2019-01-08 AU AU2019205821A patent/AU2019205821A1/en active Pending
- 2019-01-08 KR KR1020207022923A patent/KR20200108867A/ko unknown
- 2019-01-08 BR BR112020013915-7A patent/BR112020013915A2/pt unknown
- 2019-01-08 WO PCT/US2019/012720 patent/WO2019136451A1/en unknown
- 2019-01-08 CA CA3087570A patent/CA3087570A1/en active Pending
- 2019-01-08 SG SG11202005937QA patent/SG11202005937QA/en unknown
- 2019-01-08 CN CN201980017478.6A patent/CN111837146A/zh active Pending
- 2019-01-08 EP EP19736263.5A patent/EP3738084A4/en active Pending
- 2019-01-08 MX MX2020007312A patent/MX2020007312A/es unknown
- 2019-01-08 PE PE2020000908A patent/PE20210121A1/es unknown
-
2020
- 2020-06-28 IL IL275708A patent/IL275708A/en unknown
- 2020-07-08 US US16/924,033 patent/US11357779B2/en active Active
- 2020-07-08 PH PH12020551050A patent/PH12020551050A1/en unknown
- 2020-07-16 CO CONC2020/0008825A patent/CO2020008825A2/es unknown
-
2022
- 2022-06-13 US US17/839,215 patent/US20230149406A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL275708A (en) | 2020-08-31 |
AU2019205821A1 (en) | 2020-07-09 |
SG11202005937QA (en) | 2020-07-29 |
MX2020007312A (es) | 2021-01-08 |
EP3738084A1 (en) | 2020-11-18 |
PH12020551050A1 (en) | 2021-08-23 |
US20230149406A1 (en) | 2023-05-18 |
RU2020123665A (ru) | 2022-02-10 |
CN111837146A (zh) | 2020-10-27 |
BR112020013915A2 (pt) | 2020-12-01 |
EP3738084A4 (en) | 2021-11-17 |
US11357779B2 (en) | 2022-06-14 |
KR20200108867A (ko) | 2020-09-21 |
JP2021509680A (ja) | 2021-04-01 |
WO2019136451A1 (en) | 2019-07-11 |
CA3087570A1 (en) | 2019-07-11 |
CO2020008825A2 (es) | 2020-07-31 |
US20200405721A1 (en) | 2020-12-31 |
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