UY31631A1 - Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicaciones - Google Patents
Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicacionesInfo
- Publication number
- UY31631A1 UY31631A1 UY031631A UY31631A UY31631A1 UY 31631 A1 UY31631 A1 UY 31631A1 UY 031631 A UY031631 A UY 031631A UY 31631 A UY31631 A UY 31631A UY 31631 A1 UY31631 A1 UY 31631A1
- Authority
- UY
- Uruguay
- Prior art keywords
- salts
- processes
- preparation
- phenil
- pirimidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención se refiere a los compuestos de la fórmula I, y sales de los mismos: en donde los sustituyentes son como se definen en la memoria descriptiva, a procesos para la preparación de los mismos; a productos farmacéuticos que contienen tales compuestos, en particular para el uso en una o más enfermedades mediadas por la cinasa de proteína tirosina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08151137 | 2008-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31631A1 true UY31631A1 (es) | 2009-09-30 |
Family
ID=39739330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY031631A UY31631A1 (es) | 2008-02-06 | 2009-02-04 | Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicaciones |
Country Status (27)
Country | Link |
---|---|
US (1) | US8420657B2 (es) |
EP (1) | EP2247591A1 (es) |
JP (1) | JP5323095B2 (es) |
KR (2) | KR20130066703A (es) |
CN (1) | CN101981036B (es) |
AR (1) | AR070558A1 (es) |
AU (1) | AU2009211338B2 (es) |
BR (1) | BRPI0908433A2 (es) |
CA (1) | CA2714177A1 (es) |
CL (1) | CL2009000255A1 (es) |
CO (1) | CO6321262A2 (es) |
CR (1) | CR11614A (es) |
DO (1) | DOP2010000242A (es) |
EA (1) | EA017952B1 (es) |
EC (1) | ECSP10010463A (es) |
IL (1) | IL207224A0 (es) |
MA (1) | MA32134B1 (es) |
MX (1) | MX2010008719A (es) |
NI (1) | NI201000137A (es) |
NZ (1) | NZ587271A (es) |
PA (1) | PA8815201A1 (es) |
PE (1) | PE20091485A1 (es) |
SM (1) | SMP201000104B (es) |
TW (1) | TW200938202A (es) |
UY (1) | UY31631A1 (es) |
WO (1) | WO2009098236A1 (es) |
ZA (1) | ZA201005338B (es) |
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TWI398252B (zh) | 2006-05-26 | 2013-06-11 | Novartis Ag | 吡咯并嘧啶化合物及其用途 |
WO2009114533A2 (en) * | 2008-03-10 | 2009-09-17 | Cornell University | Modulation of blood brain barrier permeability |
BRPI0917791B1 (pt) * | 2008-08-22 | 2022-03-22 | Novartis Ag | Compostos de pirrolopirimidina como inibidores de cdk, bem como composição farmacêutica e combinação |
US8546377B2 (en) | 2009-04-23 | 2013-10-01 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
US8518933B2 (en) * | 2009-04-23 | 2013-08-27 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
EP2421870B1 (en) * | 2009-04-23 | 2016-03-09 | AbbVie Inc. | Modulators of 5-ht receptors and methods of use thereof |
BR112012009327A2 (pt) * | 2009-10-20 | 2017-06-06 | Cellzome Ltd | análogos de heterociclil pirazolopirimidina como inibidores de jak |
CN104370909B (zh) * | 2009-12-01 | 2018-09-11 | Abbvie 公司 | 三环化合物 |
US8791100B2 (en) | 2010-02-02 | 2014-07-29 | Novartis Ag | Aryl benzylamine compounds |
UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
UY33226A (es) * | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina deuterada como inhibidores de la cdk4/6 |
KR20130094693A (ko) * | 2010-04-30 | 2013-08-26 | 셀좀 리미티드 | Jak 저해제로서의 피라졸 화합물 |
WO2012003829A1 (en) | 2010-07-09 | 2012-01-12 | Leo Pharma A/S | Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
JP2013534233A (ja) * | 2010-08-20 | 2013-09-02 | セルゾーム リミティッド | 選択的jak阻害剤としてのヘテロシクリルピラゾロピリミジン類似体 |
US20130224110A1 (en) * | 2010-09-16 | 2013-08-29 | Cornell University | Use of adenosine receptor signaling to modulate permeability of blood-brain barrier |
WO2012143320A1 (en) | 2011-04-18 | 2012-10-26 | Cellzome Limited | (7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors |
EA030465B1 (ru) | 2011-07-01 | 2018-08-31 | Новартис Аг | Комбинированная терапия, включающая ингибитор cdk4/6 и ингибитор pi3k для применения в лечении рака |
RU2014115476A (ru) * | 2011-09-20 | 2015-10-27 | Целльзом Лимитед | Производные пиразоло[4, 3-с]птридина в качестве ингибиторов киназ |
CA2855619A1 (en) | 2011-11-15 | 2013-05-23 | Novartis Ag | Combination of a phosphoinositide 3-kinase inhibitor and a modulator of the janus kinase 2 - signal transducer and activator of transcription 5 pathway |
CN102627646A (zh) * | 2012-03-19 | 2012-08-08 | 苏州四同医药科技有限公司 | 一种3-碘-5-溴-4,7-二氮杂吲哚的制备方法 |
CN102633802B (zh) * | 2012-04-11 | 2014-03-19 | 南京药石药物研发有限公司 | 一种合成2-氯-7H-吡咯并[2,3-d]嘧啶的中间体及其制法 |
WO2013170671A1 (zh) * | 2012-05-14 | 2013-11-21 | 华东理工大学 | 蝶啶酮衍生物及其作为egfr、blk、flt3抑制剂的应用 |
CN103059030B (zh) * | 2012-12-28 | 2015-04-29 | 北京师范大学 | 一种具有粘着斑激酶抑制作用的嘧啶类化合物及其制备方法和应用 |
WO2014145576A2 (en) | 2013-03-15 | 2014-09-18 | Northwestern University | Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer |
WO2015143692A1 (en) * | 2014-03-28 | 2015-10-01 | Changzhou Jiekai Pharmatech Co., Ltd. | Heterocyclic compounds as axl inhibitors |
CR20160512A (es) | 2014-05-01 | 2016-12-21 | Novartis Ag | Compuestos y composiciones como agonistas del receptor tipo toll 7 |
NZ724878A (en) | 2014-05-01 | 2019-03-29 | Novartis Ag | Compounds and compositions as toll-like receptor 7 agonists |
MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
CN112423759A (zh) | 2018-03-30 | 2021-02-26 | 因赛特公司 | 使用jak抑制剂治疗化脓性汗腺炎 |
CN111484496B (zh) * | 2019-01-29 | 2022-11-29 | 江苏开元药业有限公司 | 2-氨基-吡咯并嘧啶和吡唑并嘧啶类化合物及其制备方法和用途 |
JP2022532877A (ja) | 2019-05-08 | 2022-07-20 | ビマラン バイオサイエンシーズ,インク. | Jak阻害剤 |
CN110305140B (zh) * | 2019-07-30 | 2020-08-04 | 上海勋和医药科技有限公司 | 二氢吡咯并嘧啶类选择性jak2抑制剂 |
MX2022001702A (es) * | 2019-08-08 | 2022-04-20 | Vimalan Biosciences Inc | Inhibidores de jak. |
GB201911868D0 (en) * | 2019-08-19 | 2019-10-02 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
EP4027993A4 (en) * | 2019-09-13 | 2023-09-20 | The Broad Institute Inc. | CYCLOOXYGENASE INHIBITORS AND USES THEREOF |
GB201914910D0 (en) * | 2019-10-15 | 2019-11-27 | Sentinel Oncology Ltd | Pharmaceutical compounds |
CN117043163A (zh) * | 2021-09-08 | 2023-11-10 | 希格生科(深圳)有限公司 | 吡咯并嘧啶类或吡咯并吡啶类衍生物及其医药用途 |
CN114957248B (zh) * | 2022-05-09 | 2023-12-29 | 南开大学 | 一种吡咯并嘧啶化合物及其制备方法、药物组合物和应用 |
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2009
- 2009-02-04 CN CN2009801117630A patent/CN101981036B/zh not_active Expired - Fee Related
- 2009-02-04 PE PE2009000162A patent/PE20091485A1/es not_active Application Discontinuation
- 2009-02-04 EP EP09708802A patent/EP2247591A1/en not_active Withdrawn
- 2009-02-04 AU AU2009211338A patent/AU2009211338B2/en not_active Ceased
- 2009-02-04 NZ NZ587271A patent/NZ587271A/en not_active IP Right Cessation
- 2009-02-04 BR BRPI0908433A patent/BRPI0908433A2/pt not_active IP Right Cessation
- 2009-02-04 JP JP2010545458A patent/JP5323095B2/ja not_active Expired - Fee Related
- 2009-02-04 EA EA201001242A patent/EA017952B1/ru not_active IP Right Cessation
- 2009-02-04 WO PCT/EP2009/051281 patent/WO2009098236A1/en active Application Filing
- 2009-02-04 KR KR1020137011455A patent/KR20130066703A/ko not_active Application Discontinuation
- 2009-02-04 CA CA2714177A patent/CA2714177A1/en not_active Abandoned
- 2009-02-04 KR KR1020107019690A patent/KR101277823B1/ko not_active IP Right Cessation
- 2009-02-04 UY UY031631A patent/UY31631A1/es not_active Application Discontinuation
- 2009-02-04 AR ARP090100362A patent/AR070558A1/es not_active Application Discontinuation
- 2009-02-04 MX MX2010008719A patent/MX2010008719A/es active IP Right Grant
- 2009-02-05 PA PA20098815201A patent/PA8815201A1/es unknown
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