MA32134B1 - Composés hétérocycliques - Google Patents

Composés hétérocycliques

Info

Publication number
MA32134B1
MA32134B1 MA33139A MA33139A MA32134B1 MA 32134 B1 MA32134 B1 MA 32134B1 MA 33139 A MA33139 A MA 33139A MA 33139 A MA33139 A MA 33139A MA 32134 B1 MA32134 B1 MA 32134B1
Authority
MA
Morocco
Prior art keywords
heterocyclic compounds
compounds
substituents
salts
formula
Prior art date
Application number
MA33139A
Other languages
Arabic (ar)
English (en)
Inventor
Christoph Gaul
Marc Gerspacher
Philipp Holzer
Soldermann Carole Pissot
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39739330&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32134(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA32134B1 publication Critical patent/MA32134B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Cette invention concerne des composés de formule i et leurs sels, les substituants étant tels que définis dans la description, ainsi que des procédés permettant de les préparer; des composés pharmaceutiques contenant ces composés, en particulier pour une utilisation dans le cadre d'une ou plusieurs maladies associées avec la tyrosine kinase.
MA33139A 2008-02-06 2010-09-02 Composés hétérocycliques MA32134B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08151137 2008-02-06
PCT/EP2009/051281 WO2009098236A1 (fr) 2008-02-06 2009-02-04 Composés hétérocycliques

Publications (1)

Publication Number Publication Date
MA32134B1 true MA32134B1 (fr) 2011-03-01

Family

ID=39739330

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33139A MA32134B1 (fr) 2008-02-06 2010-09-02 Composés hétérocycliques

Country Status (27)

Country Link
US (1) US8420657B2 (fr)
EP (1) EP2247591A1 (fr)
JP (1) JP5323095B2 (fr)
KR (2) KR20130066703A (fr)
CN (1) CN101981036B (fr)
AR (1) AR070558A1 (fr)
AU (1) AU2009211338B2 (fr)
BR (1) BRPI0908433A2 (fr)
CA (1) CA2714177A1 (fr)
CL (1) CL2009000255A1 (fr)
CO (1) CO6321262A2 (fr)
CR (1) CR11614A (fr)
DO (1) DOP2010000242A (fr)
EA (1) EA017952B1 (fr)
EC (1) ECSP10010463A (fr)
IL (1) IL207224A0 (fr)
MA (1) MA32134B1 (fr)
MX (1) MX2010008719A (fr)
NI (1) NI201000137A (fr)
NZ (1) NZ587271A (fr)
PA (1) PA8815201A1 (fr)
PE (1) PE20091485A1 (fr)
SM (1) SMP201000104B (fr)
TW (1) TW200938202A (fr)
UY (1) UY31631A1 (fr)
WO (1) WO2009098236A1 (fr)
ZA (1) ZA201005338B (fr)

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WO2012143320A1 (fr) 2011-04-18 2012-10-26 Cellzome Limited Composés (7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine comme inhibiteurs de la jak3
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CN103059030B (zh) * 2012-12-28 2015-04-29 北京师范大学 一种具有粘着斑激酶抑制作用的嘧啶类化合物及其制备方法和应用
WO2014145576A2 (fr) 2013-03-15 2014-09-18 Northwestern University Pyrrolo(2,3-d)pyrimidines substituées pour le traitement du cancer
CN106458914B (zh) * 2014-03-28 2020-01-14 常州捷凯医药科技有限公司 作为axl抑制剂的杂环化合物
MX362341B (es) 2014-05-01 2019-01-11 Novartis Ag Compuestos y composiciones como agonistas del receptor tipo toll 7.
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MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
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CN111484496B (zh) * 2019-01-29 2022-11-29 江苏开元药业有限公司 2-氨基-吡咯并嘧啶和吡唑并嘧啶类化合物及其制备方法和用途
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Also Published As

Publication number Publication date
KR20130066703A (ko) 2013-06-20
EP2247591A1 (fr) 2010-11-10
AR070558A1 (es) 2010-04-21
ECSP10010463A (es) 2010-10-30
WO2009098236A1 (fr) 2009-08-13
PE20091485A1 (es) 2009-10-26
US20090203688A1 (en) 2009-08-13
NI201000137A (es) 2011-09-29
CO6321262A2 (es) 2011-09-20
ZA201005338B (en) 2011-09-28
CA2714177A1 (fr) 2009-08-13
KR20100119786A (ko) 2010-11-10
PA8815201A1 (es) 2009-09-17
AU2009211338B2 (en) 2011-12-15
AU2009211338A1 (en) 2009-08-13
EA017952B1 (ru) 2013-04-30
MX2010008719A (es) 2010-09-24
EA201001242A1 (ru) 2011-08-30
CN101981036B (zh) 2013-09-04
SMP201000104B (it) 2011-09-09
CN101981036A (zh) 2011-02-23
JP5323095B2 (ja) 2013-10-23
DOP2010000242A (es) 2010-08-31
CR11614A (es) 2010-09-06
JP2011511034A (ja) 2011-04-07
IL207224A0 (en) 2010-12-30
TW200938202A (en) 2009-09-16
BRPI0908433A2 (pt) 2019-09-24
SMAP201000104A (it) 2010-11-12
NZ587271A (en) 2012-03-30
CL2009000255A1 (es) 2009-08-14
UY31631A1 (es) 2009-09-30
KR101277823B1 (ko) 2013-07-15
US8420657B2 (en) 2013-04-16

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