MA33772B1 - Dérivés d'acide carboxylique cyclique substitué par acylamino et leur utilisation en tant qu'agents pharmaceutiques - Google Patents
Dérivés d'acide carboxylique cyclique substitué par acylamino et leur utilisation en tant qu'agents pharmaceutiquesInfo
- Publication number
- MA33772B1 MA33772B1 MA34905A MA34905A MA33772B1 MA 33772 B1 MA33772 B1 MA 33772B1 MA 34905 A MA34905 A MA 34905A MA 34905 A MA34905 A MA 34905A MA 33772 B1 MA33772 B1 MA 33772B1
- Authority
- MA
- Morocco
- Prior art keywords
- acilamino
- cyclo
- pharmaceuticals
- alternative
- carboxylic acid
- Prior art date
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Abstract
A PRÉSENTE INVENTION CONCERNE DES COMPOSÉS PHARMACEUTIQUEMENT ACTIFS INTÉRESSANTS DE FORMULE (I), OÙ A, Y, Z, R20 À R22 ET R50 SONT TELS QUE DÉFINIS DANS LES REVENDICATIONS. L'INVENTION CONCERNE, PLUS PRÉCISÉMENT, DES INHIBITEURS DU RÉCEPTEUR 2 DU GÈNE DE LA DIFFÉRENTIATION ENDOTHÉLIALE (EDG-2, EDG2), QUI EST ACTIVÉ PAR L'ACIDE LYSOPHOSPHATIDIQUE (LPA) ET QUI EST ÉGALEMENT CONNU SOUS LE NOM DE RÉCEPTEUR LPA1. LESDITS COMPOSÉS PEUVENT ÊTRE UTILISÉS DANS LE CADRE DU TRAITEMENT DE MALADIES TELLES QUE L'ATHÉROSCLÉROSE, L'INFARCTUS DU MYOCARDE ET L'INSUFFISANCE CARDIAQUE PAR EXEMPLE. L'INVENTION CONCERNE, EN OUTRE, DES PROCÉDÉS DE PRÉPARATION DES COMPOSÉS DE FORMULE (I), LEUR UTILISATION ET DES COMPOSITIONS PHARMACEUTIQUES EN CONTENANT.
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EP09290831 | 2009-11-02 | ||
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PCT/US2010/055035 WO2011053948A1 (fr) | 2009-11-02 | 2010-11-02 | Dérivés cycliques acylamino-substitués de l'acide carboxylique et leur utilisation en tant que produits pharmaceutiques |
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EP (1) | EP2496556B1 (fr) |
JP (1) | JP5847088B2 (fr) |
KR (1) | KR20120101429A (fr) |
CN (1) | CN102858745A (fr) |
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MA (1) | MA33772B1 (fr) |
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UY (1) | UY32990A (fr) |
WO (1) | WO2011053948A1 (fr) |
ZA (1) | ZA201202635B (fr) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2451796B1 (fr) | 2009-07-08 | 2013-04-17 | Dermira (Canada), Inc. | Analogues de tofa utiles dans le traitement de troubles ou états dermatologiques |
CN104066729A (zh) | 2011-08-15 | 2014-09-24 | 英特穆恩公司 | 溶血磷脂酸受体拮抗剂 |
WO2013070879A1 (fr) | 2011-11-10 | 2013-05-16 | Bristol-Myers Squibb Company | Méthodes de traitement de lésion de la moelle épinière par des antagonistes du récepteur du lpa |
US9254288B2 (en) * | 2012-05-07 | 2016-02-09 | The Translational Genomics Research Institute | Susceptibility of tumors to tyrosine kinase inhibitors and treatment thereof |
AU2013276617B9 (en) | 2012-06-13 | 2018-03-29 | F. Hoffmann-La Roche Ag | New diazaspirocycloalkane and azaspirocycloalkane |
SI2900669T1 (sl) | 2012-09-25 | 2019-12-31 | F. Hoffmann-La Roche Ag | Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic |
US9169214B2 (en) | 2012-12-21 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
MY187449A (en) | 2013-11-26 | 2021-09-22 | Hoffmann La Roche | New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl |
DK3122750T3 (da) | 2014-03-26 | 2019-11-04 | Hoffmann La Roche | Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere |
PE20161223A1 (es) | 2014-03-26 | 2016-11-12 | Hoffmann La Roche | Compuestos condensados de [1,4]diazepina como inhibidores de la produccion de autotaxina (atx) y acido lisofosfatidico (lpa) |
JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
CN108064224B (zh) | 2014-10-30 | 2022-03-29 | 詹森药业有限公司 | 作为Rorγt的调节剂的酰胺取代的噻唑 |
EP3212641B1 (fr) | 2014-10-30 | 2018-12-05 | Janssen Pharmaceutica NV | Thiazoles en tant que modulateurs de roryt |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
EP3302465A1 (fr) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles pour le traitement de maladies liées à la démyélinisation |
JP6886967B2 (ja) | 2015-09-04 | 2021-06-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | フェノキシメチル誘導体 |
CN107614505B (zh) | 2015-09-24 | 2021-05-07 | 豪夫迈·罗氏有限公司 | 作为双重atx/ca抑制剂的新型二环化合物 |
JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Atx阻害剤としての二環式化合物 |
BR112018006024A2 (pt) | 2015-09-24 | 2020-05-12 | F. Hoffmann-La Roche Ag | Compostos bicíclicos como inibidores de atx |
MA42923A (fr) | 2015-09-24 | 2021-04-28 | Hoffmann La Roche | Composés bicycliques comme inhibiteurs mixtes de atx/ca |
TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為RORγT調節劑之6-胺基吡啶-3-基噻唑 |
WO2018106646A1 (fr) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles pour traiter des maladies démyélinisantes |
WO2018106641A1 (fr) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles pour le traitement de maladies démyélinisantes |
WO2018106643A1 (fr) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Azoles hétérocycliques pour le traitement de maladies de démyélinisation |
SG11201906922TA (en) | 2017-02-17 | 2019-09-27 | Eidos Therapeutics Inc | Processes for preparing ag-10, its intermediates, and salts thereof |
WO2018167113A1 (fr) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Nouveaux composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
RU2019132254A (ru) | 2017-03-16 | 2021-04-16 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca |
US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
CN108276307A (zh) * | 2018-01-17 | 2018-07-13 | 常熟浸大科技有限公司 | 3-氰基-4-烃氧基苯甲酸酯的合成方法 |
CA3094711A1 (fr) | 2018-03-23 | 2019-09-26 | Eidos Therapeutics, Inc. | Methodes de traitement de l'amylose ttr a l'aide d'ag10 |
US10975057B2 (en) | 2018-06-18 | 2021-04-13 | Janssen Pharmaceutica Nv | 6-aminopyridin-3-yl pyrazoles as modulators of RORgT |
CN112334450A (zh) | 2018-06-18 | 2021-02-05 | 詹森药业有限公司 | 作为RORγt的调节剂的苯基和吡啶基取代的咪唑 |
CA3103929A1 (fr) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Pyrazoles substitues par phenyle utilises en tant que modulateurs de roryt |
CN112292373A (zh) | 2018-06-18 | 2021-01-29 | 詹森药业有限公司 | 作为RORγt的调节剂的吡啶基吡唑类 |
US20200085810A1 (en) * | 2018-07-26 | 2020-03-19 | Hoffmann-La Roche Inc. | Compounds for use in treating kidney disorders |
TWI834708B (zh) | 2018-08-17 | 2024-03-11 | 美商文涵治療有限公司 | Ag10之調配物 |
KR102224677B1 (ko) * | 2018-08-23 | 2021-03-08 | 가천대학교 산학협력단 | 티아졸로 피페라진 유도체 및 이를 유효성분으로 함유하는 자가면역질환 예방 또는 치료용 조성물 |
KR20220101137A (ko) | 2019-11-15 | 2022-07-19 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제로서의 트라이아졸 카르바메이트 피리딜 설폰아미드 및 이의 용도 |
CN111574389B (zh) * | 2020-05-14 | 2023-08-18 | 河北威远生物化工有限公司 | 1-氨基-4-取代环己基羧酸及其盐的顺式异构体的制备方法 |
TWI838626B (zh) | 2020-06-03 | 2024-04-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
CN115867556A (zh) | 2020-06-03 | 2023-03-28 | 吉利德科学公司 | Lpa受体拮抗剂及其用途 |
EP4337641A1 (fr) | 2021-05-11 | 2024-03-20 | Gilead Sciences, Inc. | Antagonistes du récepteur lpa et leurs utilisations |
WO2023107938A1 (fr) | 2021-12-08 | 2023-06-15 | Gilead Sciences, Inc. | Antagonistes du récepteur lpa et leurs utilisations |
AR128613A1 (es) | 2022-02-25 | 2024-05-29 | Lhotse Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor de lpa |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5259644A (en) * | 1975-11-11 | 1977-05-17 | Sankyo Co Ltd | Stabilizer for polymer |
DE3602016A1 (de) | 1985-12-05 | 1987-06-11 | Bayer Ag | Pyri(mi)dyl-oxy- und thio-benzoesaeure-derivate |
ATE218549T1 (de) | 1993-07-28 | 2002-06-15 | Aventis Pharma Ltd | Verbindungen als pde iv und tnf inhibitoren |
AU2300699A (en) * | 1998-02-17 | 1999-08-30 | Ono Pharmaceutical Co. Ltd. | Amidino derivatives and drugs containing the same as the active ingredient |
HUP0101587A3 (en) | 1998-03-27 | 2003-03-28 | Genentech Inc | Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders |
EE200100487A (et) * | 1999-03-15 | 2003-02-17 | Axys Pharmaceuticals, Inc. | Uudsed ühendid ja kompositsioonid proteaasiinhibiitoritena |
WO2001060819A1 (fr) | 2000-02-18 | 2001-08-23 | Kirin Beer Kabushiki Kaisha | Nouveaux composes d'isoxazole et de thiazole et leur utilisation en tant que medicaments |
DE10033353A1 (de) | 2000-07-08 | 2002-01-24 | Aventis Pharma Gmbh | Breit einsetzbares Verfahren zur Identifizierung von Modulatoren von G-Protein gekoppelten Rezeptoren |
US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
WO2002029001A2 (fr) | 2000-10-03 | 2002-04-11 | University Of Virginian Patent Foundation | Nouveaux agonistes et antagonistes des recepteurs de l'acide lysophosphatidique |
CA2473740A1 (fr) | 2002-01-18 | 2003-07-31 | David Solow-Cordero | Procedes pour traiter des pathologies associees a un recepteur d'edg |
AU2003241833A1 (en) | 2002-05-28 | 2003-12-12 | Ono Pharmaceutical Co., Ltd. | Beta-ALANINE DERIVATIVE AND USE THEREOF |
KR100962972B1 (ko) * | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-페닐피페리딘-3-온 유도체 및 그의 제조방법 |
EP1569954A1 (fr) * | 2002-12-05 | 2005-09-07 | Axys Pharmaceuticals, Inc. | Derives de cyanomethyle en tant qu'inhibiteurs de la protease a cysteine |
CN102977015B (zh) | 2003-06-06 | 2015-05-06 | 菲布罗根有限公司 | 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途 |
AU2004259012C1 (en) | 2003-07-23 | 2012-08-02 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
CN1839132A (zh) | 2003-08-21 | 2006-09-27 | Osi制药公司 | 作为c-kit抑制剂的n3-取代的咪唑并吡啶衍生物 |
ATE528276T1 (de) | 2003-12-19 | 2011-10-15 | Ono Pharmaceutical Co | Lysophosphatidylsäurerezeptor-antagonistische verbindungen und ihre anwendungen |
EP1750722A4 (fr) | 2004-05-06 | 2010-03-10 | Univ Virginia | Nouveaux antagonistes selectifs du recepteur de l'acide lysophosphatidique |
US7683097B2 (en) * | 2004-05-27 | 2010-03-23 | Propharmacon Inc. | Topoisomerase inhibitors |
GB2414403B (en) | 2004-05-28 | 2009-01-07 | Cilag Ag Int | Injection device |
ES2357015T3 (es) * | 2004-10-15 | 2011-04-15 | Bayer Healthcare Llc | Preparación y uso de derivados bifenil-4-ilcarbonilaminoácido para el tratamiento de la obesidad. |
ATE502025T1 (de) | 2004-10-19 | 2011-04-15 | Compass Pharmaceuticals Llc | Arylcarboxamide und ihre verwendung als antitumormittel |
JP2008519761A (ja) * | 2004-11-09 | 2008-06-12 | スミスクライン ビーチャム コーポレーション | グリコーゲンホスホリラーゼ阻害化合物およびその医薬組成物 |
EP1849465A4 (fr) | 2005-02-18 | 2008-12-24 | Takeda Pharmaceutical | Agent de controle de la fonction du recepteur gpr34 |
ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
EP1910367A2 (fr) | 2005-05-20 | 2008-04-16 | Alantos Pharmaceuticals, Inc. | Derives bicycliques de pyrimidine et triazine condenses comme inhibiteurs de metalloprotease |
EP1912634A4 (fr) * | 2005-07-29 | 2010-06-09 | Bayer Healthcare Llc | Preparation et utilisation de derives aminoacides biphenyle pour traiter l'obesite |
JP4047365B2 (ja) * | 2006-01-11 | 2008-02-13 | 生化学工業株式会社 | シクロアルカンカルボキサミド誘導体及びその製造方法 |
EP2040688B1 (fr) | 2006-06-28 | 2014-04-02 | Sanofi | Nouveaux inhibiteurs de cxcr2. |
FR2904827B1 (fr) * | 2006-08-11 | 2008-09-19 | Sanofi Aventis Sa | Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii |
NZ588807A (en) | 2008-05-05 | 2011-07-29 | Sanofi Aventis | Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals |
CA2724998A1 (fr) * | 2008-06-18 | 2009-12-23 | Pfizer Limited | Derives de nicotinamide |
-
2010
- 2010-10-29 AR ARP100104007 patent/AR079022A1/es not_active Application Discontinuation
- 2010-11-01 TW TW99137400A patent/TW201127379A/zh unknown
- 2010-11-01 UY UY32990A patent/UY32990A/es not_active Application Discontinuation
- 2010-11-02 CN CN2010800603352A patent/CN102858745A/zh active Pending
- 2010-11-02 AU AU2010313162A patent/AU2010313162A1/en not_active Abandoned
- 2010-11-02 CA CA2779268A patent/CA2779268A1/fr not_active Abandoned
- 2010-11-02 EP EP10776045.6A patent/EP2496556B1/fr active Active
- 2010-11-02 JP JP2012537183A patent/JP5847088B2/ja not_active Expired - Fee Related
- 2010-11-02 RU RU2012122805/04A patent/RU2012122805A/ru not_active Application Discontinuation
- 2010-11-02 WO PCT/US2010/055035 patent/WO2011053948A1/fr active Application Filing
- 2010-11-02 MX MX2012004739A patent/MX2012004739A/es not_active Application Discontinuation
- 2010-11-02 BR BR112012010282A patent/BR112012010282A2/pt not_active IP Right Cessation
- 2010-11-02 PE PE2012000558A patent/PE20121477A1/es not_active Application Discontinuation
- 2010-11-02 KR KR20127014323A patent/KR20120101429A/ko not_active Application Discontinuation
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2012
- 2012-04-04 TN TNP2012000160A patent/TN2012000160A1/en unknown
- 2012-04-12 ZA ZA2012/02635A patent/ZA201202635B/en unknown
- 2012-04-22 IL IL219354A patent/IL219354A0/en unknown
- 2012-04-25 CR CR20120203A patent/CR20120203A/es unknown
- 2012-04-26 DO DO2012000121A patent/DOP2012000121A/es unknown
- 2012-04-30 EC ECSP12011861 patent/ECSP12011861A/es unknown
- 2012-05-01 US US13/461,264 patent/US8618304B2/en not_active Expired - Fee Related
- 2012-05-02 CO CO12071019A patent/CO6541540A2/es unknown
- 2012-05-30 MA MA34905A patent/MA33772B1/fr unknown
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2013
- 2013-11-27 US US14/091,511 patent/US9018383B2/en not_active Expired - Fee Related
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Publication number | Publication date |
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AR079022A1 (es) | 2011-12-21 |
KR20120101429A (ko) | 2012-09-13 |
EP2496556B1 (fr) | 2018-12-26 |
CO6541540A2 (es) | 2012-10-16 |
EP2496556A1 (fr) | 2012-09-12 |
BR112012010282A2 (pt) | 2016-03-29 |
CR20120203A (es) | 2012-06-01 |
MX2012004739A (es) | 2012-05-22 |
TW201127379A (en) | 2011-08-16 |
RU2012122805A (ru) | 2013-12-10 |
IL219354A0 (en) | 2012-06-28 |
US20120264790A1 (en) | 2012-10-18 |
ZA201202635B (en) | 2013-01-30 |
JP5847088B2 (ja) | 2016-01-20 |
US8618304B2 (en) | 2013-12-31 |
TN2012000160A1 (en) | 2013-12-12 |
AU2010313162A1 (en) | 2012-05-24 |
WO2011053948A1 (fr) | 2011-05-05 |
CN102858745A (zh) | 2013-01-02 |
JP2013509446A (ja) | 2013-03-14 |
DOP2012000121A (es) | 2012-07-31 |
PE20121477A1 (es) | 2012-11-14 |
US20140088158A1 (en) | 2014-03-27 |
CA2779268A1 (fr) | 2011-05-05 |
US9018383B2 (en) | 2015-04-28 |
ECSP12011861A (es) | 2012-10-30 |
UY32990A (es) | 2011-05-31 |
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