MA32781B1 - Arycyclohexylethers de dihydrotetrazabenzoazulenes pour emploi en tant qu'antagonistes du recepteur v1a de la vasopressine - Google Patents

Arycyclohexylethers de dihydrotetrazabenzoazulenes pour emploi en tant qu'antagonistes du recepteur v1a de la vasopressine

Info

Publication number
MA32781B1
MA32781B1 MA33827A MA33827A MA32781B1 MA 32781 B1 MA32781 B1 MA 32781B1 MA 33827 A MA33827 A MA 33827A MA 33827 A MA33827 A MA 33827A MA 32781 B1 MA32781 B1 MA 32781B1
Authority
MA
Morocco
Prior art keywords
disorders
arylcyclohexyl
concerns
ether derivatives
dihydrotetrazapenzoazole
Prior art date
Application number
MA33827A
Other languages
Arabic (ar)
English (en)
Inventor
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA32781B1 publication Critical patent/MA32781B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

LA PRÉSENTE INVENTION CONCERNE DES DÉRIVÉS DE TYPE ARYLCYCLOHEXYLÉTHER DE DIHYDROTÉTRAZABENZOAZULÈNE, PLUS PRÉCISÉMENT DES DÉRIVÉS DE TYPE ARYLCYCLOHEXYLÉTHERS DE 5,6-DIHYDRO-4H-2,3,5,10B-TÉTRAZA-BENZO[E]AZULÈNE DE FORMULE (I) OÙ R1, R2 ET R3 SONT TELS QUE DÉCRITS DANS LA PRÉSENTE INVENTION. LES COMPOSÉS SELON L'INVENTION AGISSENT EN TANT QUE MODULATEURS DES RÉCEPTEURS V1A, ET EN PARTICULIER EN TANT QU'ANTAGONISTES DES RÉCEPTEURS V1A. LA PRÉSENTE INVENTION CONCERNE ÉGALEMENT LEUR FABRICATION, LES COMPOSITIONS PHARMACEUTIQUES LES INCLUANT ET LEUR EMPLOI EN TANT QUE MÉDICAMENT. LES PRINCIPES ACTIFS SELON L'INVENTION PEUVENT ÊTRE EMPLOYÉS EN TANT QUE PRODUITS THÉRAPEUTIQUES À ACTION PÉRIPHÉRIQUE OU CENTRALE DANS LES ÉTATS DE DYSMÉNORRHÉE, DE DYSFONCTIONNEMENT SEXUEL CHEZ L'HOMME OU LA FEMME, D'HYPERTENSION, D'INSUFFISANCE CARDIAQUE CHRONIQUE, DE SÉCRÉTION INADAPTÉE DE VASOPRESSINE, DE CIRRHOSE DU FOIE, DE SYNDROME NÉPHROTIQUE, D'ANXIÉTÉ, DE TROUBLES DÉPRESSIFS, DE TROUBLES OBSESSIONNELS COMPULSIFS, DE TROUBLES DU SPECTRE AUTISTIQUE, DE SCHIZOPHRÉNIE ET DE COMPORTEMENT AGRESSIF.
MA33827A 2008-11-28 2011-05-10 Arycyclohexylethers de dihydrotetrazabenzoazulenes pour emploi en tant qu'antagonistes du recepteur v1a de la vasopressine MA32781B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08170188 2008-11-28
PCT/EP2009/065354 WO2010060836A1 (fr) 2008-11-28 2009-11-18 Arylcyclohexyléthers de dihydrotétrazabenzoazulènes pour emploi en tant qu'antagonistes du récepteur v1a de la vasopressine

Publications (1)

Publication Number Publication Date
MA32781B1 true MA32781B1 (fr) 2011-11-01

Family

ID=41382009

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33827A MA32781B1 (fr) 2008-11-28 2011-05-10 Arycyclohexylethers de dihydrotetrazabenzoazulenes pour emploi en tant qu'antagonistes du recepteur v1a de la vasopressine

Country Status (32)

Country Link
US (2) US8227458B2 (fr)
EP (1) EP2370441B1 (fr)
JP (1) JP5452608B2 (fr)
KR (1) KR101359742B1 (fr)
CN (1) CN102227428B (fr)
AR (2) AR074409A1 (fr)
AU (1) AU2009319123B2 (fr)
BR (1) BRPI0922303B1 (fr)
CA (1) CA2743976C (fr)
CO (1) CO6341478A2 (fr)
CR (1) CR20110220A (fr)
CY (1) CY1115435T1 (fr)
DK (1) DK2370441T3 (fr)
EC (1) ECSP11011089A (fr)
ES (1) ES2431279T3 (fr)
HK (1) HK1160642A1 (fr)
HR (1) HRP20131067T1 (fr)
IL (1) IL212122A (fr)
MA (1) MA32781B1 (fr)
MX (1) MX2011005596A (fr)
MY (1) MY150837A (fr)
NZ (1) NZ592076A (fr)
PE (1) PE20110582A1 (fr)
PL (1) PL2370441T3 (fr)
PT (1) PT2370441E (fr)
RU (1) RU2507205C2 (fr)
SG (1) SG171846A1 (fr)
SI (1) SI2370441T1 (fr)
TW (1) TWI379833B (fr)
UA (1) UA103504C2 (fr)
WO (1) WO2010060836A1 (fr)
ZA (1) ZA201103419B (fr)

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WO2013050334A1 (fr) * 2011-10-05 2013-04-11 F. Hoffmann-La Roche Ag Cyclohexyl-4h,6h-5-oxa-2,3,10b-triazabenzo[e]azulènes utilisés comme antagonistes des v1a
WO2015024819A1 (fr) * 2013-08-19 2015-02-26 F. Hoffmann-La Roche Ag Antagonistes de v1a pour traiter des troubles du sommeil impliquant un décalage de phase
NZ720340A (en) 2013-12-05 2020-03-27 Hoffmann La Roche Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crystalline forms thereof
WO2017191117A1 (fr) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Antagonistes du récepteur v1a destinés à une utilisation dans le traitement de maladies rénales
RU2666598C1 (ru) * 2017-07-14 2018-09-11 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Средство для коррекции расстройств аутистического спектра
US11033601B2 (en) 2017-09-14 2021-06-15 The Regents Of The University Of Colorado, A Body Corporate Selective inhibition of V1b for treating fatty liver
AU2018379448A1 (en) * 2017-12-08 2020-03-12 F. Hoffmann-La Roche Ag Pharmaceutical formulation
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
WO2020139670A1 (fr) 2018-12-27 2020-07-02 Teva Pharmaceuticals International Gmbh Formes à l'état solide de balovaptan

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Also Published As

Publication number Publication date
HRP20131067T1 (hr) 2013-12-06
IL212122A (en) 2013-06-27
US20100137286A1 (en) 2010-06-03
EP2370441B1 (fr) 2013-09-11
UA103504C2 (ru) 2013-10-25
AU2009319123A1 (en) 2010-06-03
AR074409A1 (es) 2011-01-12
EP2370441A1 (fr) 2011-10-05
MY150837A (en) 2014-02-28
MX2011005596A (es) 2011-06-16
IL212122A0 (en) 2011-06-30
ES2431279T3 (es) 2013-11-25
WO2010060836A1 (fr) 2010-06-03
DK2370441T3 (da) 2013-10-21
PT2370441E (pt) 2013-11-14
CO6341478A2 (es) 2011-11-21
RU2507205C2 (ru) 2014-02-20
KR20110077022A (ko) 2011-07-06
ECSP11011089A (es) 2011-06-30
AR112338A2 (es) 2019-10-16
CA2743976C (fr) 2017-02-21
SG171846A1 (en) 2011-07-28
US20120225865A1 (en) 2012-09-06
BRPI0922303B1 (pt) 2019-11-12
JP2012510441A (ja) 2012-05-10
PE20110582A1 (es) 2011-08-17
CR20110220A (es) 2011-06-21
US8227458B2 (en) 2012-07-24
CY1115435T1 (el) 2017-01-04
CN102227428A (zh) 2011-10-26
TW201024300A (en) 2010-07-01
RU2011123703A (ru) 2013-01-10
PL2370441T3 (pl) 2014-02-28
CA2743976A1 (fr) 2010-06-03
TWI379833B (en) 2012-12-21
CN102227428B (zh) 2015-03-25
JP5452608B2 (ja) 2014-03-26
AU2009319123B2 (en) 2014-10-23
KR101359742B1 (ko) 2014-02-06
HK1160642A1 (en) 2012-08-10
US8461152B2 (en) 2013-06-11
NZ592076A (en) 2012-06-29
BRPI0922303A2 (pt) 2016-01-12
ZA201103419B (en) 2014-07-30
SI2370441T1 (sl) 2013-12-31

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