MA35874B1 - Dérivés d'amide cycliques à utiliser en tant qu'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase et utilisations de ceux-ci - Google Patents

Dérivés d'amide cycliques à utiliser en tant qu'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase et utilisations de ceux-ci

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Publication number
MA35874B1
MA35874B1 MA37227A MA37227A MA35874B1 MA 35874 B1 MA35874 B1 MA 35874B1 MA 37227 A MA37227 A MA 37227A MA 37227 A MA37227 A MA 37227A MA 35874 B1 MA35874 B1 MA 35874B1
Authority
MA
Morocco
Prior art keywords
compounds
treatment
amide derivatives
hydroxysteroid dehydrogenase
beta
Prior art date
Application number
MA37227A
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English (en)
Inventor
Jagannath Madanahalli Ranganath Rao
Uppala Venkatesham
Jenson George
George Fernand
Sivanageswara Rao Doppalapudi
G R Madhavan
Nagarajan Arumugam
Mohammed Ansari
K Murugavel
Jidugu Pradeep
Sulthan Allavuddeen
K Vijayaramalingam
Hampelingaiah Shiva Prasad
Augustine Michael Raj
S Gnanavel
Ramamoorthy Kottamalai
Naresh M P S Babu
Bommegowda Yadaganahalli Kenchegowda
Original Assignee
Connexios Life Sciences Pvt Ltd
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Application filed by Connexios Life Sciences Pvt Ltd filed Critical Connexios Life Sciences Pvt Ltd
Publication of MA35874B1 publication Critical patent/MA35874B1/fr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

La présente invention concerne certains dérivés d'amide qui ont la capacité d'inhiber la 11-ß-hydroxystéroïde déshydrogénase de type 1 (11ß-hsd-1) et qui sont par conséquent utiles dans le traitement de certains troubles dont la prévention ou le traitement peuvent être assurés par l'inhibition de cette enzyme. L'invention concerne également des composés, des procédés pour leur préparation, des compositions pharmaceutiques contenant ces composés et des utilisations de ces composés dans le traitement de certains troubles. Lesdits composés sont prévus pour être utilisés dans le traitement d'états tels que le diabète de type 2 non insulinodépendant (dnid), la résistance à l'insuline, l'obésité, l'hyperglycémie modérée à jeun, l'intolérance au glucose, les troubles lipidiques tels que la dyslipidémie, l'hypertension ainsi que d'autres maladies et états.
MA37227A 2011-12-22 2014-07-20 Dérivés d'amide cycliques à utiliser en tant qu'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase et utilisations de ceux-ci MA35874B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4527CH2011 2011-12-22
PCT/IN2012/000841 WO2013128465A1 (fr) 2011-12-22 2012-12-21 Dérivés d'amide cycliques à utiliser en tant qu'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase et utilisations de ceux-ci

Publications (1)

Publication Number Publication Date
MA35874B1 true MA35874B1 (fr) 2014-12-01

Family

ID=54258979

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37227A MA35874B1 (fr) 2011-12-22 2014-07-20 Dérivés d'amide cycliques à utiliser en tant qu'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase et utilisations de ceux-ci

Country Status (21)

Country Link
US (1) US9453014B2 (fr)
EP (1) EP2800748B1 (fr)
JP (1) JP6118340B2 (fr)
KR (1) KR102083040B1 (fr)
CN (1) CN104125956B (fr)
AU (1) AU2012372019B2 (fr)
BR (1) BR112014015301A8 (fr)
CA (1) CA2860187C (fr)
CL (1) CL2014001704A1 (fr)
CO (1) CO7160013A2 (fr)
DK (1) DK2800748T3 (fr)
ES (1) ES2630309T3 (fr)
IL (1) IL233270A0 (fr)
MA (1) MA35874B1 (fr)
MX (1) MX354361B (fr)
MY (1) MY173696A (fr)
PH (1) PH12014501442A1 (fr)
RU (1) RU2669695C2 (fr)
SG (1) SG11201403268QA (fr)
WO (1) WO2013128465A1 (fr)
ZA (1) ZA201405263B (fr)

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CN103415589B (zh) 2011-10-05 2016-08-10 日东电工株式会社 具有提高日光采集效率的压敏粘附层的波长转换膜
AR089284A1 (es) 2011-12-22 2014-08-13 Galapagos Nv Dihidropirimidinoisoquinolinonas y composiciones farmaceuticas de las mismas para el tratamiento de trastornos inflamatorios
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
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WO2016004272A1 (fr) 2014-07-02 2016-01-07 Pharmacyclics Llc Inhibiteurs de la tyrosine kinase de bruton
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BR112019015552A2 (pt) 2017-02-24 2020-03-17 The Regents Of The University Of California Composições e métodos para promover crescimento capilar com os inibidores de mpc1
KR20250151619A (ko) * 2017-06-30 2025-10-21 더 리전트 오브 더 유니버시티 오브 캘리포니아 모발 성장을 조절하기 위한 조성물 및 방법
EP4172159A4 (fr) 2020-06-30 2024-01-10 The Regents of the University of California Compositions et procédés de modulation de la pousse des cheveux
US12577240B2 (en) 2020-07-11 2026-03-17 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
CN118724781B (zh) * 2024-06-05 2025-09-16 延安大学 新型手性胺基酰胺-硒醚配体及其制备方法

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JP2015521154A (ja) 2015-07-27
US20150158860A1 (en) 2015-06-11
BR112014015301A8 (pt) 2017-07-04
WO2013128465A1 (fr) 2013-09-06
DK2800748T3 (en) 2017-07-17
US9453014B2 (en) 2016-09-27
CN104125956B (zh) 2019-08-16
MX354361B (es) 2018-02-28
RU2014126646A (ru) 2016-02-10
JP6118340B2 (ja) 2017-04-19
BR112014015301A2 (pt) 2017-06-13
KR20140127226A (ko) 2014-11-03
EP2800748A1 (fr) 2014-11-12
PH12014501442B1 (en) 2014-10-08
CN104125956A (zh) 2014-10-29
ZA201405263B (en) 2016-05-25
EP2800748B1 (fr) 2017-03-29
MX2014007719A (es) 2015-03-19
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PH12014501442A1 (en) 2014-10-08
CO7160013A2 (es) 2015-01-15
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AU2012372019B2 (en) 2017-06-15
KR102083040B1 (ko) 2020-02-28
SG11201403268QA (en) 2014-07-30
CA2860187C (fr) 2020-11-10
NZ626745A (en) 2016-06-24
AU2012372019A1 (en) 2014-07-24
CA2860187A1 (fr) 2013-09-06
RU2669695C2 (ru) 2018-10-15
CL2014001704A1 (es) 2015-03-13

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