MA30018B1 - Derives de 1-orthofluorophenyl substitues 1, 2, 5-thiazolidinedione utilises comme inhibiteurs de la ptp-ase - Google Patents

Derives de 1-orthofluorophenyl substitues 1, 2, 5-thiazolidinedione utilises comme inhibiteurs de la ptp-ase

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Publication number
MA30018B1
MA30018B1 MA30986A MA30986A MA30018B1 MA 30018 B1 MA30018 B1 MA 30018B1 MA 30986 A MA30986 A MA 30986A MA 30986 A MA30986 A MA 30986A MA 30018 B1 MA30018 B1 MA 30018B1
Authority
MA
Morocco
Prior art keywords
compounds
diseases
inhibitors
ptpases
formula
Prior art date
Application number
MA30986A
Other languages
English (en)
Inventor
David Barnes
Gary Mark Coppola
Travis Stams
Sidney Wolf Topiol
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37903424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30018(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30018B1 publication Critical patent/MA30018B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12—Antihypertensives
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

Les composés de formule : sont des inhibiteurs des protéine-tyrosine-phosphatases (PTPases) et peuvent ainsi être utilisés pour le traitement d'affections induites par l'activité des PTPases. Les composés de la présente invention peuvent également être utilisés comme inhibiteurs d'autres enzymes caractérisées par une région de liaison à la phosphotyrosine, comme le domaine SH2. Par conséquent, les composés de formule (I) peuvent être utilisés pour la prévention et/ou le traitement d'une résistance à l'insuline associée à l'obésité, d'une intolérance au glucose, du diabète sucré, de l'hypertension et de maladies ischémiques des gros et des petits vaisseaux sanguins, d'affections qui accompagnent le diabète de type 2, y compris une hyperlipidémie, une hypertriglycéridémie, l'athérosclérose, une resténose vasculaire, le syndrome du côlon irritable, la pancréatite, des tumeurs et carcinomes à cellules adipeuses, tels que le liposarcome, une dyslipidémie et d'autres affections dans lesquelles est indiquée une résistance à l'insuline. De plus, les composés de la présente invention peuvent être utilisés pour traiter et/ou prévenir un cancer, l'ostéoporose, des maladies neurodégénératives et infectieuses, et des maladies impliquant une inflammation et le système immunitaire.
MA30986A 2005-12-08 2008-06-02 Derives de 1-orthofluorophenyl substitues 1, 2, 5-thiazolidinedione utilises comme inhibiteurs de la ptp-ase MA30018B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74849205P 2005-12-08 2005-12-08

Publications (1)

Publication Number Publication Date
MA30018B1 true MA30018B1 (fr) 2008-12-01

Family

ID=37903424

Family Applications (1)

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MA30986A MA30018B1 (fr) 2005-12-08 2008-06-02 Derives de 1-orthofluorophenyl substitues 1, 2, 5-thiazolidinedione utilises comme inhibiteurs de la ptp-ase

Country Status (23)

Country Link
US (1) US8252820B2 (fr)
EP (1) EP1963293A1 (fr)
JP (1) JP2009518419A (fr)
KR (1) KR20080075218A (fr)
CN (1) CN101336235A (fr)
AR (1) AR058285A1 (fr)
AU (1) AU2006321902B2 (fr)
BR (1) BRPI0619567A2 (fr)
CA (1) CA2631007A1 (fr)
CR (1) CR10047A (fr)
EC (1) ECSP088509A (fr)
GT (1) GT200800093A (fr)
IL (1) IL191711A0 (fr)
MA (1) MA30018B1 (fr)
NO (1) NO20083030L (fr)
NZ (1) NZ568663A (fr)
PE (2) PE20071094A1 (fr)
RU (1) RU2008127262A (fr)
TN (1) TNSN08248A1 (fr)
TW (1) TW200800928A (fr)
UA (1) UA94921C2 (fr)
WO (1) WO2007067612A1 (fr)
ZA (1) ZA200804489B (fr)

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WO2012120055A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
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WO2012147516A1 (fr) 2011-04-28 2012-11-01 持田製薬株式会社 Dérivé d'amide cyclique
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EA202190805A1 (ru) 2018-09-18 2021-06-23 Басф Се Диаминотриазиновые соединения
EP3938038A1 (fr) 2019-03-14 2022-01-19 Calico Life Sciences LLC Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation
JP2023507774A (ja) * 2019-12-18 2023-02-27 カリコ ライフ サイエンシーズ エルエルシー タンパク質チロシンホスファターゼ阻害剤及びそれらの使用方法
CA3162364A1 (fr) * 2019-12-20 2021-06-24 Gesine Kerstin Veits Agents de degradation de proteine tyrosine phosphatase et leurs methodes d'utilisation
MX2023002953A (es) * 2020-09-11 2023-06-01 Calico Life Sciences Llc Inhibidores de proteína tirosina fosfatasa y métodos para su uso.
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JP2024509962A (ja) * 2021-03-11 2024-03-05 カムクワット バイオサイエンシーズ インコーポレイテッド 複素環及びその使用
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CR10047A (es) 2008-10-16
CN101336235A (zh) 2008-12-31
US8252820B2 (en) 2012-08-28
WO2007067612A1 (fr) 2007-06-14
UA94921C2 (en) 2011-06-25
BRPI0619567A2 (pt) 2011-10-04
CA2631007A1 (fr) 2007-06-14
NZ568663A (en) 2011-07-29
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AU2006321902A1 (en) 2007-06-14
ZA200804489B (en) 2009-08-26
ECSP088509A (es) 2008-07-30
TW200800928A (en) 2008-01-01
AU2006321902B2 (en) 2011-11-10
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RU2008127262A (ru) 2010-01-20
PE20100470A1 (es) 2010-07-13

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