NO20083030L - 1-Orthofluorfenyl-substituert 1,2,5-tiazolidindionderivater som PTP-AS inhibitorer - Google Patents

1-Orthofluorfenyl-substituert 1,2,5-tiazolidindionderivater som PTP-AS inhibitorer

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Publication number
NO20083030L
NO20083030L NO20083030A NO20083030A NO20083030L NO 20083030 L NO20083030 L NO 20083030L NO 20083030 A NO20083030 A NO 20083030A NO 20083030 A NO20083030 A NO 20083030A NO 20083030 L NO20083030 L NO 20083030L
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NO
Norway
Prior art keywords
compounds
inhibitors
formula
treatment
insulin resistance
Prior art date
Application number
NO20083030A
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English (en)
Inventor
Gary Mark Coppola
Travis Mathew Stams
Sidney Wolf Topiol
David Barnes
Original Assignee
Novartis Ag
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37903424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083030(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20083030L publication Critical patent/NO20083030L/no

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
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  • Ophthalmology & Optometry (AREA)
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Abstract

Forbindelser med formel (I) er inhibitorer av proteintyrosinfosfataser (PTPaser) og kan således anvendes for behandlingen av tilstander mediert av PTPase aktivitet. Forbindelsene ifølge oppfinnelsen kan også anvendes som inhibitorer av andre enzymer kjennetegnet ved en fosfotyrosinbindingsregion slik som SH2 domenet. Følgelig kan forbindelsene med formel (I) anvendes for hindring og/eller behandling av insulinresistens assosiert med fedme, glukoseintoleranse, diabetes mellitus, hypertensjon og iskemiske sykdommer i store og små blodkar, tilstander som ledsager type-2 diabetes, inkludert hyperlipidemi, hypertriglyceridemi, aterosklerose, vaskulær restenose, irritabelt tarmsyndrom, pankreatitt, adiposecelletumorer og karsinomer slike som liposarkom, dyslipidemi og andre forstyrrelser hvor insulinresistens er indikert. I tillegg kan forbindelsene ifølge oppfinnelsen anvendes for behandling og/eller hindring av cancer, osteoporose, neurodegenerative og infeksjonssykdommer og sykdommer som involverer inflammasjon og immunsystemet.
NO20083030A 2005-12-08 2008-07-04 1-Orthofluorfenyl-substituert 1,2,5-tiazolidindionderivater som PTP-AS inhibitorer NO20083030L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74849205P 2005-12-08 2005-12-08
PCT/US2006/046542 WO2007067612A1 (en) 2005-12-08 2006-12-06 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as ptp-as inhibitors

Publications (1)

Publication Number Publication Date
NO20083030L true NO20083030L (no) 2008-08-28

Family

ID=37903424

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083030A NO20083030L (no) 2005-12-08 2008-07-04 1-Orthofluorfenyl-substituert 1,2,5-tiazolidindionderivater som PTP-AS inhibitorer

Country Status (23)

Country Link
US (1) US8252820B2 (no)
EP (1) EP1963293A1 (no)
JP (1) JP2009518419A (no)
KR (1) KR20080075218A (no)
CN (1) CN101336235A (no)
AR (1) AR058285A1 (no)
AU (1) AU2006321902B2 (no)
BR (1) BRPI0619567A2 (no)
CA (1) CA2631007A1 (no)
CR (1) CR10047A (no)
EC (1) ECSP088509A (no)
GT (1) GT200800093A (no)
IL (1) IL191711A0 (no)
MA (1) MA30018B1 (no)
NO (1) NO20083030L (no)
NZ (1) NZ568663A (no)
PE (2) PE20100470A1 (no)
RU (1) RU2008127262A (no)
TN (1) TNSN08248A1 (no)
TW (1) TW200800928A (no)
UA (1) UA94921C2 (no)
WO (1) WO2007067612A1 (no)
ZA (1) ZA200804489B (no)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080293782A1 (en) * 2005-12-08 2008-11-27 David Barnes 1,1,3-Trioxo-1,2,5-Thiadiazolidines and Their Use as Ptp-Ases Inhibitors
KR20080074970A (ko) * 2005-12-08 2008-08-13 노파르티스 아게 단백질 티로신 포스파타제 (ｐｔｐａｓｅ)에 의해 매개되는질병의 치료에 유용한 1,2,5-티아졸리딘 유도체
BRPI0710182A2 (pt) * 2006-03-31 2012-08-07 Novartis Ag compostos orgÂnicos.
DE102007015169A1 (de) * 2007-03-27 2008-10-02 Universität des Saarlandes Campus Saarbrücken 17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US20130109887A1 (en) * 2010-08-26 2013-05-02 Albermarle Corporation Processes for producing 1-bromo-2- (cyclopropyl methoxy)-5-fluoro-4-methoxybenzene
US9040525B2 (en) 2010-10-08 2015-05-26 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
JPWO2012147516A1 (ja) 2011-04-28 2014-07-28 持田製薬株式会社 環状アミド誘導体
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2017078499A2 (ko) * 2015-11-06 2017-05-11 경북대학교 산학협력단 단백질 타이로신 탈인산화효소 억제제를 포함하는 신경염증성 질환의 예방 또는 치료용 조성물
PE20210372A1 (es) * 2018-06-21 2021-02-26 Abbvie Inc Inhibidores de proteina tirosina fosfatasa y sus metodos de uso
MX2021003240A (es) 2018-09-18 2021-05-12 Basf Se Compuestos de diaminotriazina.
AU2020234712A1 (en) * 2019-03-14 2021-09-09 Abbvie Inc. Protein tyrosine phosphatase inhibitors and methods of use thereof
EP4077291A1 (en) * 2019-12-18 2022-10-26 Calico Life Sciences LLC Protein tyrosine phosphatase inhibitors and methods of use thereof
WO2021127586A1 (en) * 2019-12-20 2021-06-24 Calico Life Sciences Llc Protein tyrosine phosphatase degraders and methods of use thereof
EP4211122A1 (en) * 2020-09-11 2023-07-19 Calico Life Sciences LLC Protein tyrosine phosphatase inhibitors and methods of use thereof
EP4284786A1 (en) 2021-01-27 2023-12-06 Basf Se Diaminotriazine compounds
JP2024509962A (ja) * 2021-03-11 2024-03-05 カムクワット バイオサイエンシーズ インコーポレイテッド 複素環及びその使用
CA3236854A1 (en) * 2021-11-11 2023-05-19 Andrew Bogdan Protein tyrosine phosphatase inhibitors and methods of use thereof
CA3236853A1 (en) * 2021-11-11 2023-05-19 Andrew Bogdan Protein tyrosine phosphatase inhibitors and methods of use thereof
WO2023147531A1 (en) * 2022-01-31 2023-08-03 Bristol-Myers Squibb Company Inhibitors of protein tyrosine phosphatase, compositions, and methods of use
TW202337459A (zh) * 2022-02-02 2023-10-01 美商耐瑞歐醫療公司 蛋白酪胺酸磷酸酶抑制劑及其用途
WO2023150150A1 (en) * 2022-02-02 2023-08-10 Nerio Therapeutics, Inc. Protein tyrosine phosphatase inhibitors and uses thereof
WO2023150523A1 (en) * 2022-02-02 2023-08-10 Nerio Therapeutics, Inc. Protein tyrosine phosphatase inhibitors and uses thereof
WO2024059041A1 (en) * 2022-09-13 2024-03-21 Kumquat Biosciences, Inc. Benzo-fused n-heterocycles and uses thereof
WO2024067802A1 (zh) * 2022-09-30 2024-04-04 深圳众格生物科技有限公司 蛋白酪氨酸磷酸酶抑制剂及其制备方法和医药用途
WO2024102794A1 (en) * 2022-11-09 2024-05-16 Bristol-Myers Squibb Company Inhibitors of protein tyrosine phosphatase, compositions, and methods of use
WO2024137727A1 (en) * 2022-12-21 2024-06-27 Bristol-Myers Squibb Company 1,2,4-thiazolidin-3-one-1,1-dioxide inhibitors of protein tyrosine phosphatase, compositions, and methods of use
WO2024141015A1 (en) * 2022-12-30 2024-07-04 Insilico Medicine Ip Limited Protein tyrosine phosphatase inhibitors and uses thereof
CN117343052B (zh) * 2023-12-04 2024-02-06 英矽智能科技(上海)有限公司 蛋白酪氨酸磷酸酶抑制剂及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002254342A1 (en) * 2001-03-23 2002-10-08 The Board Of Trustees Of The University Of Illinois Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same
PL372848A1 (en) * 2002-04-03 2005-08-08 Novartis Ag 5-substituted 1,1-dioxo-[1,2,5]thiazolidine-3-one derivatives as ptpase 1b inhibitors
GB0225986D0 (en) * 2002-11-07 2002-12-11 Astrazeneca Ab Chemical compounds
GB0227813D0 (en) * 2002-11-29 2003-01-08 Astrazeneca Ab Chemical compounds
EP1594497B1 (en) * 2002-12-30 2009-05-27 Vertex Pharmaceuticals Incorporated Sulfhydantoins as phosphate isosteres for use as phosphatase inhibitors in the treatment of cancer and autoimmune disorders
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US7141596B2 (en) * 2003-10-08 2006-11-28 Incyte Corporation Inhibitors of proteins that bind phosphorylated molecules
US20080293782A1 (en) 2005-12-08 2008-11-27 David Barnes 1,1,3-Trioxo-1,2,5-Thiadiazolidines and Their Use as Ptp-Ases Inhibitors
UA94724C2 (en) * 2005-12-08 2011-06-10 Новартис Аг Thiadiazolidinone derivatives as antidiabetic agents
KR20080074970A (ko) 2005-12-08 2008-08-13 노파르티스 아게 단백질 티로신 포스파타제 (ｐｔｐａｓｅ)에 의해 매개되는질병의 치료에 유용한 1,2,5-티아졸리딘 유도체
BRPI0710182A2 (pt) 2006-03-31 2012-08-07 Novartis Ag compostos orgÂnicos.

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CR10047A (es) 2008-10-16
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AR058285A1 (es) 2008-01-30
US8252820B2 (en) 2012-08-28
ZA200804489B (en) 2009-08-26
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BRPI0619567A2 (pt) 2011-10-04
TW200800928A (en) 2008-01-01
PE20071094A1 (es) 2008-01-07
AU2006321902B2 (en) 2011-11-10
KR20080075218A (ko) 2008-08-14
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JP2009518419A (ja) 2009-05-07
UA94921C2 (en) 2011-06-25
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