MA30782B1 - Amides substitues, procede de production et d'utilisation desdits amides - Google Patents
Amides substitues, procede de production et d'utilisation desdits amidesInfo
- Publication number
- MA30782B1 MA30782B1 MA31766A MA31766A MA30782B1 MA 30782 B1 MA30782 B1 MA 30782B1 MA 31766 A MA31766 A MA 31766A MA 31766 A MA31766 A MA 31766A MA 30782 B1 MA30782 B1 MA 30782B1
- Authority
- MA
- Morocco
- Prior art keywords
- amides
- methods
- chemical entity
- activity
- production
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 2
- 150000005829 chemical entities Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE AU MOINS UNE ENTITÉ CHIMIQUE CHOISIE PARMI DES COMPOSÉS DE FORMULE (1) ET DES SELS, DES SOLVATES, DES CHÉLATES, DES COMPLEXES NON-COVALENTS, DES PRO-MÉDICAMENTS DE QUALITÉ PHARMACEUTIQUE, ET DES MÉLANGES DE CES SUBSTANCES. ELLE CONCERNE ÉGALEMENT DES COMPOSITIONS PHARMACEUTIQUES COMPORTANT AU MOINS UNE ENTITÉ CHIMIQUE SELON L'INVENTION, AINSI QU'UN VÉHICULE DE QUALITÉ PHARMACEUTIQUE CHOISI PARMI DES ADJUVANTS TRANSPORTEURS ET DES EXCIPIENTS. DES MÉTHODES DE TRAITEMENT DE PATIENTS SOUFFRANT DE CERTAINES MALADIES RÉPONDANT À L'INHIBITION DE L'ACTIVITÉ BTK ET / OU DE L'ACTIVITÉ DES LYMPHOCYTES B, AINSI QUE DES MÉTHODES DE DÉTERMINATION DE LA PRÉSENCE DE BTK DANS UN ÉCHANTILLON SONT ÉGALEMENT DÉCRITES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84395906P | 2006-09-11 | 2006-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30782B1 true MA30782B1 (fr) | 2009-10-01 |
Family
ID=38951317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31766A MA30782B1 (fr) | 2006-09-11 | 2009-04-06 | Amides substitues, procede de production et d'utilisation desdits amides |
Country Status (23)
Country | Link |
---|---|
US (1) | US8058446B2 (fr) |
EP (1) | EP2081923B1 (fr) |
JP (1) | JP5295961B2 (fr) |
KR (1) | KR101442585B1 (fr) |
CN (1) | CN101679361A (fr) |
AR (1) | AR063706A1 (fr) |
AU (1) | AU2007296559B2 (fr) |
BR (1) | BRPI0716918A2 (fr) |
CA (2) | CA2661654C (fr) |
CL (1) | CL2007002640A1 (fr) |
CO (1) | CO6160313A2 (fr) |
CR (1) | CR10710A (fr) |
EC (1) | ECSP099239A (fr) |
ES (1) | ES2576478T3 (fr) |
IL (1) | IL197230A0 (fr) |
MA (1) | MA30782B1 (fr) |
MX (1) | MX2009002649A (fr) |
NO (1) | NO20091424L (fr) |
PE (1) | PE20080839A1 (fr) |
RU (1) | RU2009113693A (fr) |
TW (1) | TW200829579A (fr) |
WO (1) | WO2008033854A1 (fr) |
ZA (1) | ZA200901633B (fr) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7838523B2 (en) * | 2006-09-11 | 2010-11-23 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
CL2008002793A1 (es) | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
CN101835755B (zh) * | 2007-10-23 | 2013-12-11 | 霍夫曼-拉罗奇有限公司 | 激酶抑制剂 |
US7683064B2 (en) | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
US8304413B2 (en) * | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
UA103327C2 (en) | 2008-06-24 | 2013-10-10 | Ф. Хоффманн-Ля Рош Аг | Substituted pyridin-2-ones and pyridazin-3-ones |
BRPI0913879A2 (pt) * | 2008-07-02 | 2019-09-24 | Hoffmann La Roche | fenilpirazinonas como inibidores de quinase |
EP2365970B1 (fr) | 2008-11-12 | 2018-03-21 | Gilead Connecticut, Inc. | Pyridazinones et leur utilisation comme inhibiteurs btk |
US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
BR112012028530A2 (pt) * | 2010-05-07 | 2017-12-19 | Genentech Inc | composto, composição farmacêutica e seu processo de preparação e método para o tratamento de uma doença ou transtorno |
AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
MX2014005289A (es) | 2011-11-03 | 2014-05-30 | Hoffmann La Roche | Compuestos de piperazina alquilados. |
ES2552514T3 (es) | 2011-11-03 | 2015-11-30 | Hoffmann-La Roche Ag | Compuestos bicíclicos de piperazina |
UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
CA2853967A1 (fr) | 2011-11-03 | 2013-05-10 | F. Hoffmann-La Roche Ag | Composes 8-fluorophtalazin-1(2h)-one comme inhibiteurs de l'activite btk |
CA2874953A1 (fr) * | 2012-06-12 | 2013-12-19 | Abbvie Inc. | Derives de pyridinone et de pyridazinone |
AU2013299557B2 (en) | 2012-08-10 | 2017-06-22 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as Bruton's tyrosine kinase (BTK) inhibitors |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
MX367918B (es) | 2013-04-25 | 2019-09-11 | Beigene Ltd | Compuestos heterociclicos fusionados como inhibidores de proteina quinasa. |
CN104177338B (zh) * | 2013-05-22 | 2018-04-03 | 南京勇山生物科技有限公司 | 一类布鲁顿激酶抑制剂 |
CN105358545A (zh) | 2013-07-03 | 2016-02-24 | 豪夫迈·罗氏有限公司 | 杂芳基吡啶酮和氮杂-吡啶酮酰胺化合物 |
EA201690127A1 (ru) | 2013-07-30 | 2016-07-29 | Джилид Коннектикут, Инк. | Состав на основе ингибиторов syk |
MY176803A (en) | 2013-07-30 | 2020-08-21 | Gilead Connecticut Inc | Polymorph of syk inhibitors |
SG11201601844TA (en) | 2013-09-13 | 2016-04-28 | Beigene Ltd | Anti-pd1 antibodies and their use as therapeutics and diagnostics |
SI3290407T1 (sl) | 2013-10-18 | 2020-07-31 | Celgene Quanticel Research, Inc | Inhibitorji bromodomene |
RU2646758C2 (ru) * | 2013-12-05 | 2018-03-07 | Ф. Хоффманн-Ля Рош Аг | Гетероарил пиридоны и азапиридоны с электрофильной функциональностью |
EP3089970B1 (fr) * | 2013-12-09 | 2018-10-17 | AbbVie Inc. | Dérivés de dihydropyridinone et de dihydropyridazinone utiles comme inhibiteurs de bromodomaines |
TWI662037B (zh) | 2013-12-23 | 2019-06-11 | 美商基利科學股份有限公司 | 脾酪胺酸激酶抑制劑 |
EP3126362B1 (fr) | 2014-04-02 | 2022-01-12 | Intermune, Inc. | Pyridinones anti-fibrotiques |
JP6526189B2 (ja) | 2014-07-03 | 2019-06-05 | ベイジーン リミテッド | 抗pd−l1抗体並びにその治療及び診断のための使用 |
EP3265453B1 (fr) * | 2015-03-05 | 2022-06-29 | Boehringer Ingelheim International GmbH | Nouvelles pyridinones et isoquinolinones utilisées comme inhibiteurs de bromodomaine brd9 |
US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
AU2016358100B2 (en) | 2015-11-19 | 2021-05-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2017106634A1 (fr) * | 2015-12-17 | 2017-06-22 | Incyte Corporation | Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation comme modulateurs d'interactions protéine/protéine pd-1/pd-l1 |
DK3394033T3 (da) | 2015-12-22 | 2021-01-04 | Incyte Corp | Heterocykliske forbindelser som immunmodulatorer |
JP6577143B2 (ja) | 2016-02-29 | 2019-09-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトンチロシンキナーゼの阻害剤を含む剤形組成物 |
MA44860A (fr) | 2016-05-06 | 2019-03-13 | Incyte Holdings Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
WO2018007885A1 (fr) | 2016-07-05 | 2018-01-11 | Beigene, Ltd. | Association d'un antagoniste de pd-1 et d'un inhibiteur du raf pour le traitement du cancer. |
ES2930092T3 (es) | 2016-07-14 | 2022-12-07 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
CA3033827A1 (fr) | 2016-08-16 | 2018-02-22 | Beigene, Ltd. | Forme cristalline de (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyle)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, sa preparation et ses utilisations |
EP4353747A3 (fr) | 2016-08-19 | 2024-06-26 | BeiGene Switzerland GmbH | Combinaison de zacuturinib avec un anticorps anti-cd20 ou anti-pd-1 pour une utilisation dans le traitement du cancer |
EP3504198B1 (fr) | 2016-08-29 | 2023-01-25 | Incyte Corporation | Composés hétérocycliques utilisés comme immunomodulateurs |
BR112019005337A2 (pt) | 2016-09-19 | 2019-08-27 | Mei Pharma Inc | terapia combinada |
MA47120A (fr) | 2016-12-22 | 2021-04-28 | Incyte Corp | Dérivés pyridine utilisés en tant qu'immunomodulateurs |
EP3558989B1 (fr) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Dérivés de triazolo[1,5-a]pyridine en tant qu'immunomodulateurs |
EP3558985B1 (fr) | 2016-12-22 | 2022-09-07 | Incyte Corporation | Dérivés de benzooxazole en tant qu'mmunomodulateurs |
MY197501A (en) | 2016-12-22 | 2023-06-19 | Incyte Corp | Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers |
WO2018137681A1 (fr) | 2017-01-25 | 2018-08-02 | Beigene, Ltd. | Formes cristallines de (s) -7- (1- (but-2-ynoyl) pipéridin-4-yl) -2- (4-phénoxyphényl) -4, 5, 6, 7-tétrahy dropyrazolo [1, 5-a] pyrimidine-3-carboxamide, préparation et utilisations associées |
JP2020514384A (ja) | 2017-03-24 | 2020-05-21 | ジェネンテック, インコーポレイテッド | 自己免疫及び炎症性疾患を治療する方法 |
EP3645569A4 (fr) | 2017-06-26 | 2021-03-24 | BeiGene, Ltd. | Immunothérapie pour carcinome hépatocellulaire |
CN110997677A (zh) | 2017-08-12 | 2020-04-10 | 百济神州有限公司 | 具有改进的双重选择性的Btk抑制剂 |
CN111051311A (zh) | 2017-08-25 | 2020-04-21 | 吉利德科学公司 | Syk抑制剂的多晶型物 |
KR102613433B1 (ko) | 2017-10-11 | 2023-12-13 | 주식회사 대웅제약 | 신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물 |
US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
EP3492454A1 (fr) * | 2017-11-30 | 2019-06-05 | Step Pharma S.A.S. | Composés |
US11655246B2 (en) | 2017-11-30 | 2023-05-23 | Step Pharma S.A.S. | Aminothiazole compounds as inhibitors of CTPS1 |
EP3717465A1 (fr) | 2017-11-30 | 2020-10-07 | Step Pharma S.A.S. | Composés |
CR20200520A (es) | 2018-03-30 | 2021-03-09 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
EP3790877B1 (fr) | 2018-05-11 | 2023-03-01 | Incyte Corporation | Dérivés de tétrahydro-imidazo[4,5-c]pyridine en tant qu'immunomodulateurs de pd-l1 |
EP3870574B1 (fr) | 2018-10-23 | 2023-01-04 | Step Pharma S.A.S. | Dérivés d' aminopyrimidine/pyrazine comme inhibiteurs de ctps1 |
US11339168B2 (en) | 2019-02-22 | 2022-05-24 | Kronos Bio, Inc. | Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors |
TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之鹽 |
TW202126652A (zh) | 2019-09-30 | 2021-07-16 | 美商英塞特公司 | 作為免疫調節劑之吡啶并[3,2—d]嘧啶化合物 |
AU2020385113A1 (en) | 2019-11-11 | 2022-05-19 | Incyte Corporation | Salts and crystalline forms of a PD-1/PD-L1 inhibitor |
CA3200844A1 (fr) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Processus de fabrication d'un inhibiteur pd-1/pd-l1 ainsi que de ses sels et formes cristallines |
TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之結晶形式 |
WO2022099018A1 (fr) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Procédé de préparation d'un inhibiteur de pd-1/pd-l1 |
US11786531B1 (en) | 2022-06-08 | 2023-10-17 | Beigene Switzerland Gmbh | Methods of treating B-cell proliferative disorder |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303652B1 (en) * | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
EP1144390A2 (fr) | 1999-01-22 | 2001-10-17 | Amgen Inc., | Inhibiteurs de kinase |
WO2005014599A1 (fr) * | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines et methodes d'inhibition de la tyrosine kinase de bruton par de tels composes |
KR20070119606A (ko) * | 2004-11-10 | 2007-12-20 | 씨지아이 파마슈티칼스, 인크. | 특정 이미다조[1,2-a]피라진-8-일아민, 그의 제조 방법및 용도 |
CA2591413A1 (fr) | 2004-12-16 | 2006-06-22 | Vertex Pharmaceuticals Incorporated | Pyrid-2-ones utiles comme inhibiteurs de proteine kinases de la famille tec pour le traitement de maladies inflammatoires, proliferatives et a mediation immunologique |
EP1863766B1 (fr) * | 2005-03-10 | 2015-05-20 | Gilead Connecticut, Inc. | Amides substitues, procede pour les produire et procede pour les utiliser |
ATE528302T1 (de) * | 2005-08-29 | 2011-10-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind |
AR063707A1 (es) * | 2006-09-11 | 2009-02-11 | Cgi Pharmaceuticals Inc | Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmacéuticas que las comprenden. |
US7838523B2 (en) * | 2006-09-11 | 2010-11-23 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
WO2008033858A2 (fr) * | 2006-09-11 | 2008-03-20 | Cgi Pharmaceuticals, Inc. | Inhibiteurs de kinase et procédés d'utilisation et d'identification des inhibiteurs de kinase |
CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
-
2007
- 2007-09-10 PE PE2007001211A patent/PE20080839A1/es not_active Application Discontinuation
- 2007-09-10 AR ARP070103988A patent/AR063706A1/es unknown
- 2007-09-11 KR KR1020097007477A patent/KR101442585B1/ko active IP Right Grant
- 2007-09-11 TW TW096133884A patent/TW200829579A/zh unknown
- 2007-09-11 CN CN200780041849A patent/CN101679361A/zh active Pending
- 2007-09-11 CL CL200702640A patent/CL2007002640A1/es unknown
- 2007-09-11 RU RU2009113693/04A patent/RU2009113693A/ru not_active Application Discontinuation
- 2007-09-11 BR BRPI0716918-3A patent/BRPI0716918A2/pt not_active Application Discontinuation
- 2007-09-11 AU AU2007296559A patent/AU2007296559B2/en not_active Ceased
- 2007-09-11 JP JP2009527625A patent/JP5295961B2/ja active Active
- 2007-09-11 ES ES07842263.1T patent/ES2576478T3/es active Active
- 2007-09-11 US US11/853,485 patent/US8058446B2/en active Active
- 2007-09-11 EP EP07842263.1A patent/EP2081923B1/fr active Active
- 2007-09-11 MX MX2009002649A patent/MX2009002649A/es not_active Application Discontinuation
- 2007-09-11 CA CA2661654A patent/CA2661654C/fr not_active Expired - Fee Related
- 2007-09-11 CA CA2941688A patent/CA2941688A1/fr not_active Abandoned
- 2007-09-11 WO PCT/US2007/078181 patent/WO2008033854A1/fr active Application Filing
-
2009
- 2009-02-24 IL IL197230A patent/IL197230A0/en unknown
- 2009-03-06 ZA ZA200901633A patent/ZA200901633B/xx unknown
- 2009-03-31 CO CO09033014A patent/CO6160313A2/es unknown
- 2009-04-03 CR CR10710A patent/CR10710A/es not_active Application Discontinuation
- 2009-04-06 MA MA31766A patent/MA30782B1/fr unknown
- 2009-04-07 NO NO20091424A patent/NO20091424L/no not_active Application Discontinuation
- 2009-04-07 EC EC2009009239A patent/ECSP099239A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2010504287A (ja) | 2010-02-12 |
EP2081923A1 (fr) | 2009-07-29 |
BRPI0716918A2 (pt) | 2013-11-05 |
IL197230A0 (en) | 2009-12-24 |
CA2661654C (fr) | 2016-10-11 |
KR101442585B1 (ko) | 2014-10-02 |
JP5295961B2 (ja) | 2013-09-18 |
EP2081923B1 (fr) | 2016-03-16 |
CN101679361A (zh) | 2010-03-24 |
AR063706A1 (es) | 2009-02-11 |
US20080139557A1 (en) | 2008-06-12 |
CR10710A (es) | 2009-07-14 |
CL2007002640A1 (es) | 2008-06-20 |
PE20080839A1 (es) | 2008-08-23 |
US8058446B2 (en) | 2011-11-15 |
ES2576478T3 (es) | 2016-07-07 |
ZA200901633B (en) | 2009-12-30 |
KR20090074762A (ko) | 2009-07-07 |
AU2007296559A1 (en) | 2008-03-20 |
NO20091424L (no) | 2009-06-10 |
WO2008033854A1 (fr) | 2008-03-20 |
CA2661654A1 (fr) | 2008-03-20 |
ECSP099239A (es) | 2009-07-31 |
RU2009113693A (ru) | 2010-10-20 |
AU2007296559B2 (en) | 2013-01-17 |
CA2941688A1 (fr) | 2008-03-20 |
CO6160313A2 (es) | 2010-05-20 |
MX2009002649A (es) | 2009-03-26 |
TW200829579A (en) | 2008-07-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA30782B1 (fr) | Amides substitues, procede de production et d'utilisation desdits amides | |
MA31276B1 (fr) | Amides substitués, procédé de production et d'utilisation desdits amides. | |
TNSN00121A1 (fr) | Composes nouveaux inhibiteurs de metalloproteases, procede pour leur preparation et compositions pharmaceutiques les contenant | |
TNSN03130A1 (fr) | Inhibiteurs de protease du vih, compositions les contenant, leurs utilisations pharmaceutiques et matieres pour leur synthese | |
MA30027B1 (fr) | [ (1h- indol- 5 -yl) -heteroaryloxy] - (1-aza-bicyclo [3.3.1] nonanes utilises en tant que ligands cholinergiques de n-achr pour le traitement des troubles psychotiques et neurodegeneratifs | |
MA29387B1 (fr) | Inhibiteurs de la dipeptidyl peptidase iv | |
MA30089B1 (fr) | (arylsulfonyl)-pyrasolopiperidines | |
MA30333B1 (fr) | Aminotetrahydropyranes utiles en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete. | |
MA30047B1 (fr) | Procede destine a traiter une lesion articulaire | |
MA30696B1 (fr) | Derives de l'acide (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetique | |
TNSN04164A1 (fr) | Inhibiteurs de acc. | |
MA30916B1 (fr) | Nouveaux derives de benzamide en tant qu'antagonistes de bradykinine | |
MA30911B1 (fr) | Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine | |
MA28077A1 (fr) | Derives d'isoquinilone 1,4-disubstitues en tant qu'inhibiteurs de raf-kinase utiles pour le traitement de maladies proliferantes | |
MA29810B1 (fr) | 4-oxy-n-[1,3,4]-thiadiazol-2-yl-benzènesulfonamides, procédés pour leur préparation et leur utilisation en tant que produits pharmaceutiques | |
TW200716551A (en) | Certain substituted amides, method of making, and method of use thereof | |
TN2009000138A1 (fr) | Biaryl-ether-urees | |
MA29377B1 (fr) | Derives de la pyrimidine pour traitement de troubles a caractere hyperproliferatif | |
TNSN99106A1 (fr) | Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
EA201190043A1 (ru) | Имидазопиразиновые ингибиторы syk | |
TNSN99006A1 (fr) | 4-(2-ceto-1-benzimidazolinyl) piperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant | |
BR0211122A (pt) | Composto, métodos para o tratamento ou prevenção de doenças e para fabricar um composto, intermediário, e, uso de um composto ou sal | |
MA29535B1 (fr) | Derives d'isoquinoline utilises en tant qu'inhibiteurs de rhokinase | |
MA30085B1 (fr) | Traitement du diabete de type 2 avec une association d'un inhibiteur de dpiv et de metformine ou d'une thiazolidinedione | |
MA29411B1 (fr) | 1h-quinazoline -2,4-diones et leur utilisation en tant que ligands du recepteur ampa |