CO6160313A2 - Piridil fenil amidas sustituidas con actividad inhibitoria de btk - Google Patents
Piridil fenil amidas sustituidas con actividad inhibitoria de btkInfo
- Publication number
- CO6160313A2 CO6160313A2 CO09033014A CO09033014A CO6160313A2 CO 6160313 A2 CO6160313 A2 CO 6160313A2 CO 09033014 A CO09033014 A CO 09033014A CO 09033014 A CO09033014 A CO 09033014A CO 6160313 A2 CO6160313 A2 CO 6160313A2
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- c4alkylene
- hydrogen
- lower alkyl
- tetrahydrobenzo
- Prior art date
Links
- WGNUNYPERJMVRM-UHFFFAOYSA-N 3-pyridylacetic acid Chemical compound OC(=O)CC1=CC=CN=C1 WGNUNYPERJMVRM-UHFFFAOYSA-N 0.000 title 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 4,5,6,7-tetrahydrobenzo [b] thiophene-2-yl Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
1.- Un compuesto CARACTERIZADO PORQUE se selecciona entre los compuestos de Fórmula I:y sales aceptables para uso farmacéutico, quelatos, complejos no covalentes, prodrogas y mezclas de los mismos, en donde R se selecciona entre arilo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R4 se selecciona entre hidrógeno, alquilo inferior opcionalmente sustituido, alcoxi inferior opcionalmente sustituido, halo, y hidroxi. R21 y R22 se seleccionan en forma independiente entre hidrógeno y alquilo inferior opcionalmente sustituido; R16 se selecciona entre hidrógeno, ciano, cicloalquilo opcionalmente sustituido, y alquilo inferior opcionalmente sustituido; L se selecciona entre C0-C4alquileno opcionalmente sustituido, -O-C0-C4alquileno opcionalmente sustituido, -(C0-C4alquileno)(SO)-, -(C0-C4alquileno)(SO2)-; y -(C0-C4alquileno)(C=O)-; y G se selecciona entre hidrógeno, halo, hidroxi, alcoxi, nitro, alquilo opcionalmente sustituido, amino opcionalmente sustituido, carbamimidoilo opcionalmente sustituido, heterocicloalquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, y heteroarilo opcionalmente sustituido. 2.- El compuesto de la reivindicación 1, CARACTERIZADO PORQUE R se selecciona entre 4,5,6,7-tetrahidrobenzo[b]tiofen-2-ilo y 4,5,6,7-tetrahidrobenzo[b]tiofen-2-ilo sustituido seleccionado entre mono-, di-, y tri-4,5,6,7-tetrahidrobenzo[b]tiofen-2-ilo sustituido en donde los sustituyentes se seleccionan en forma independiente entre hidroxi, alquilo inferior, sulfonilo, halo, alcoxi inferior, y heteroarilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84395906P | 2006-09-11 | 2006-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6160313A2 true CO6160313A2 (es) | 2010-05-20 |
Family
ID=38951317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09033014A CO6160313A2 (es) | 2006-09-11 | 2009-03-31 | Piridil fenil amidas sustituidas con actividad inhibitoria de btk |
Country Status (23)
Country | Link |
---|---|
US (1) | US8058446B2 (es) |
EP (1) | EP2081923B1 (es) |
JP (1) | JP5295961B2 (es) |
KR (1) | KR101442585B1 (es) |
CN (1) | CN101679361A (es) |
AR (1) | AR063706A1 (es) |
AU (1) | AU2007296559B2 (es) |
BR (1) | BRPI0716918A2 (es) |
CA (2) | CA2941688A1 (es) |
CL (1) | CL2007002640A1 (es) |
CO (1) | CO6160313A2 (es) |
CR (1) | CR10710A (es) |
EC (1) | ECSP099239A (es) |
ES (1) | ES2576478T3 (es) |
IL (1) | IL197230A0 (es) |
MA (1) | MA30782B1 (es) |
MX (1) | MX2009002649A (es) |
NO (1) | NO20091424L (es) |
PE (1) | PE20080839A1 (es) |
RU (1) | RU2009113693A (es) |
TW (1) | TW200829579A (es) |
WO (1) | WO2008033854A1 (es) |
ZA (1) | ZA200901633B (es) |
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CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
WO2009053269A1 (en) * | 2007-10-23 | 2009-04-30 | F. Hoffmann-La Roche Ag | Novel kinase inhibitors |
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ES2420854T3 (es) * | 2008-07-02 | 2013-08-27 | F. Hoffmann-La Roche Ag | Nuevas fenilpirazinonas como inhibidores de quinasas |
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US6303652B1 (en) * | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
EP1144390A2 (en) * | 1999-01-22 | 2001-10-17 | Amgen Inc., | Kinase inhibitors |
WO2005014599A1 (en) * | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
MX2007005643A (es) * | 2004-11-10 | 2008-03-13 | Cgi Pharmaceuticals Inc | Ciertas imidazo [1,2-a] pirazin-8-ilaminas, metodo para su elaboracion y metodo de uso de las mismas. |
MX2007007330A (es) | 2004-12-16 | 2007-10-04 | Vertex Pharma | Piridonas de utilidad como inhibidores de quinasas . |
TW200716551A (en) | 2005-03-10 | 2007-05-01 | Cgi Pharmaceuticals Inc | Certain substituted amides, method of making, and method of use thereof |
ATE528302T1 (de) * | 2005-08-29 | 2011-10-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind |
US20100160292A1 (en) * | 2006-09-11 | 2010-06-24 | Cgi Pharmaceuticals, Inc | Kinase Inhibitors, and Methods of Using and Identifying Kinase Inhibitors |
AR063707A1 (es) * | 2006-09-11 | 2009-02-11 | Cgi Pharmaceuticals Inc | Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmacéuticas que las comprenden. |
US7838523B2 (en) * | 2006-09-11 | 2010-11-23 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
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- 2007-09-10 AR ARP070103988A patent/AR063706A1/es unknown
- 2007-09-11 MX MX2009002649A patent/MX2009002649A/es not_active Application Discontinuation
- 2007-09-11 TW TW096133884A patent/TW200829579A/zh unknown
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- 2007-09-11 CA CA2941688A patent/CA2941688A1/en not_active Abandoned
- 2007-09-11 JP JP2009527625A patent/JP5295961B2/ja active Active
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- 2007-09-11 BR BRPI0716918-3A patent/BRPI0716918A2/pt not_active Application Discontinuation
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- 2007-09-11 WO PCT/US2007/078181 patent/WO2008033854A1/en active Application Filing
- 2007-09-11 EP EP07842263.1A patent/EP2081923B1/en active Active
- 2007-09-11 CN CN200780041849A patent/CN101679361A/zh active Pending
- 2007-09-11 RU RU2009113693/04A patent/RU2009113693A/ru not_active Application Discontinuation
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MA30782B1 (fr) | 2009-10-01 |
KR20090074762A (ko) | 2009-07-07 |
EP2081923A1 (en) | 2009-07-29 |
US20080139557A1 (en) | 2008-06-12 |
CR10710A (es) | 2009-07-14 |
NO20091424L (no) | 2009-06-10 |
AU2007296559A1 (en) | 2008-03-20 |
BRPI0716918A2 (pt) | 2013-11-05 |
IL197230A0 (en) | 2009-12-24 |
RU2009113693A (ru) | 2010-10-20 |
JP5295961B2 (ja) | 2013-09-18 |
ECSP099239A (es) | 2009-07-31 |
CA2661654C (en) | 2016-10-11 |
TW200829579A (en) | 2008-07-16 |
PE20080839A1 (es) | 2008-08-23 |
KR101442585B1 (ko) | 2014-10-02 |
CA2941688A1 (en) | 2008-03-20 |
ES2576478T3 (es) | 2016-07-07 |
CL2007002640A1 (es) | 2008-06-20 |
ZA200901633B (en) | 2009-12-30 |
CA2661654A1 (en) | 2008-03-20 |
AR063706A1 (es) | 2009-02-11 |
AU2007296559B2 (en) | 2013-01-17 |
EP2081923B1 (en) | 2016-03-16 |
MX2009002649A (es) | 2009-03-26 |
US8058446B2 (en) | 2011-11-15 |
JP2010504287A (ja) | 2010-02-12 |
WO2008033854A1 (en) | 2008-03-20 |
CN101679361A (zh) | 2010-03-24 |
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