MA31867B1 - Agonistes nouveaux des recepteurs de glucocorticoides - Google Patents

Agonistes nouveaux des recepteurs de glucocorticoides

Info

Publication number
MA31867B1
MA31867B1 MA32873A MA32873A MA31867B1 MA 31867 B1 MA31867 B1 MA 31867B1 MA 32873 A MA32873 A MA 32873A MA 32873 A MA32873 A MA 32873A MA 31867 B1 MA31867 B1 MA 31867B1
Authority
MA
Morocco
Prior art keywords
glucocorticoid receptors
disorders
new agonist
new
agonist
Prior art date
Application number
MA32873A
Other languages
Arabic (ar)
English (en)
Inventor
Paul Alan Glossop
David Simon Millan
David Anthony Price
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40427125&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31867(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of MA31867B1 publication Critical patent/MA31867B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DE NOUVEAUX AGONISTES DES RÉCEPTEURS DES GLUCOCORTICOÏDES DE FORMULE (I) ET DES PROCÉDÉS ET DES INTERMÉDIAIRES POUR LEUR PRÉPARATION. LA PRÉSENTE INVENTION CONCERNE ÉGALEMENT DES COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSÉS, LEUR COMBINAISON AVEC UN OU PLUSIEURS AUTRES AGENTS THÉRAPEUTIQUES AINSI QUE LEUR UTILISATION POUR LE TRAITEMENT D'UN CERTAIN NOMBRE DE MALADIES, TROUBLES ET AFFECTIONS INFLAMMATOIRES ET ALLERGIQUES.
MA32873A 2007-11-30 2010-05-28 Agonistes nouveaux des recepteurs de glucocorticoides MA31867B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99135407P 2007-11-30 2007-11-30
US5724108P 2008-05-30 2008-05-30
US7955508P 2008-07-10 2008-07-10
PCT/IB2008/054801 WO2009069032A2 (fr) 2007-11-30 2008-11-17 Nouveaux agonistes des récepteurs des glucocorticoïdes

Publications (1)

Publication Number Publication Date
MA31867B1 true MA31867B1 (fr) 2010-11-01

Family

ID=40427125

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32873A MA31867B1 (fr) 2007-11-30 2010-05-28 Agonistes nouveaux des recepteurs de glucocorticoides

Country Status (33)

Country Link
US (2) US8822439B2 (fr)
EP (1) EP2225256B1 (fr)
JP (1) JP4686650B2 (fr)
KR (1) KR101295998B1 (fr)
CN (1) CN101878221B (fr)
AP (1) AP2010005267A0 (fr)
AR (1) AR069490A1 (fr)
AU (1) AU2008331187B2 (fr)
BR (1) BRPI0820447A2 (fr)
CA (1) CA2706180C (fr)
CL (1) CL2008003549A1 (fr)
CO (1) CO6280401A2 (fr)
CR (1) CR11393A (fr)
DK (1) DK2225256T3 (fr)
DO (1) DOP2010000161A (fr)
EA (1) EA201070535A1 (fr)
EC (1) ECSP10010209A (fr)
ES (1) ES2399945T3 (fr)
GT (1) GT201000153A (fr)
HK (1) HK1144821A1 (fr)
IL (1) IL205356A0 (fr)
MA (1) MA31867B1 (fr)
MX (1) MX2010005861A (fr)
NI (1) NI201000090A (fr)
NZ (1) NZ585434A (fr)
PA (1) PA8805801A1 (fr)
PE (1) PE20091072A1 (fr)
SV (1) SV2010003580A (fr)
TN (1) TN2010000230A1 (fr)
TW (1) TW200930378A (fr)
UY (1) UY31496A1 (fr)
WO (1) WO2009069032A2 (fr)
ZA (1) ZA201003439B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2524057B1 (fr) * 2010-01-15 2016-03-30 Rigel Pharmaceuticals, Inc. Essai de criblage utilisant dex et gdf8
TW201139369A (en) 2010-02-05 2011-11-16 Chiesi Farma Spa Pyrrolidine derivatives
RU2013141933A (ru) * 2011-03-15 2015-03-20 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные изоксазолидина
CN103391945B (zh) * 2011-03-15 2016-11-09 奇斯药制品公司 异噁唑烷衍生物
FR2984325A1 (fr) * 2011-12-14 2013-06-21 Sanofi Sa Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique
TW201422590A (zh) 2012-09-07 2014-06-16 Abbvie Inc 雜環核激素受體調節劑
WO2014094357A1 (fr) 2012-12-21 2014-06-26 Abbvie Inc. Modulateurs hétérocycliques des récepteurs nucléaires aux hormones
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
WO2014144512A1 (fr) * 2013-03-15 2014-09-18 Aprecia Pharmaceuticals Company Forme pharmaceutique à dispersion rapide contenant du lévétiracétam
EP3244893A4 (fr) 2015-02-18 2019-01-09 Parion Sciences, Inc. Bloqueurs de canaux sodiques pour le traitement de troubles de la peau
CR20180594A (es) * 2016-06-02 2019-07-29 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados del mismo
CA3128468A1 (fr) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Inhibiteurs de la kinase p38 reduisant l'expression du gene dux4 et des genes aval pour le traitement de la fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
AU2018374633A1 (en) * 2017-12-01 2020-05-21 Abbvie Inc. Anti-CD40 antibody drug conjugates
RU2020117698A (ru) * 2017-12-01 2022-01-04 Эббви Инк. Агонист глюкокортикоидного рецептора и его иммуноконъюгаты
EP3768324A1 (fr) 2018-03-22 2021-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de modulation de l'activité des cellules lymphoïdes innées, conjugués anticorps-médicaments et leurs utilisations en thérapie
CN109575095A (zh) * 2019-01-20 2019-04-05 湖南科瑞生物制药股份有限公司 一种16a-羟基醋酸泼尼松龙的制备方法
CN109575097A (zh) * 2019-01-20 2019-04-05 湖南科瑞生物制药股份有限公司 一种16a-羟基泼尼松龙产品的新的制备方法
CN109734763A (zh) * 2019-01-20 2019-05-10 湖南科瑞生物制药股份有限公司 一种16a-羟基醋酸泼尼松龙产品的制备方法
CN109651474A (zh) * 2019-01-20 2019-04-19 湖南科瑞生物制药股份有限公司 一种16a-羟基泼尼松龙的新的制备方法
TW202304462A (zh) 2021-03-23 2023-02-01 美商美國禮來大藥廠 糖皮質素受體激動劑
AR125079A1 (es) 2021-03-23 2023-06-07 Lilly Co Eli Agonistas de receptores de glucocorticoides sustituidos con carboxi
WO2022268176A1 (fr) * 2021-06-24 2022-12-29 江苏先声药业有限公司 Composé stéroïde, composition pharmaceutique et utilisation associées
WO2023245106A1 (fr) * 2022-06-16 2023-12-21 Abbvie Biotherapeutics Inc. Conjugués médicament-anticorps anti-cd19

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197469A (en) * 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US8232304B2 (en) 2002-10-24 2012-07-31 G & R Pharmaceuticals, Llc Antifungal formulations
WO2005044759A2 (fr) * 2003-08-14 2005-05-19 Sun Pharmaceutical Industries Limited Acetalisation pour preparation de composes steroides
WO2005028495A1 (fr) * 2003-09-24 2005-03-31 Glaxo Group Limited Glucocorticoïdes anti-inflammatoires
GB0402797D0 (en) 2004-02-09 2004-03-10 Novartis Ag Organic compounds
US20050227927A1 (en) 2004-03-31 2005-10-13 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis

Also Published As

Publication number Publication date
HK1144821A1 (en) 2011-03-11
MX2010005861A (es) 2010-06-11
CA2706180C (fr) 2012-10-23
KR20100074306A (ko) 2010-07-01
CO6280401A2 (es) 2011-05-20
TN2010000230A1 (fr) 2011-11-11
US20140336160A1 (en) 2014-11-13
AP2010005267A0 (en) 2010-06-30
ZA201003439B (en) 2011-02-23
CA2706180A1 (fr) 2009-06-04
EP2225256B1 (fr) 2013-01-09
TW200930378A (en) 2009-07-16
WO2009069032A2 (fr) 2009-06-04
SV2010003580A (es) 2011-03-23
NZ585434A (en) 2012-06-29
EP2225256A2 (fr) 2010-09-08
PE20091072A1 (es) 2009-07-23
CR11393A (es) 2010-05-19
EA201070535A1 (ru) 2010-12-30
CN101878221B (zh) 2014-04-02
CL2008003549A1 (es) 2009-11-20
DK2225256T3 (da) 2013-03-11
AR069490A1 (es) 2010-01-27
AU2008331187B2 (en) 2014-04-03
AU2008331187A1 (en) 2009-06-04
US20090227548A1 (en) 2009-09-10
BRPI0820447A2 (pt) 2015-05-26
CN101878221A (zh) 2010-11-03
GT201000153A (es) 2012-04-27
JP4686650B2 (ja) 2011-05-25
JP2011505350A (ja) 2011-02-24
PA8805801A1 (es) 2009-07-23
ECSP10010209A (es) 2010-06-29
IL205356A0 (en) 2010-12-30
ES2399945T3 (es) 2013-04-04
WO2009069032A3 (fr) 2009-08-06
KR101295998B1 (ko) 2013-08-13
NI201000090A (es) 2010-10-04
DOP2010000161A (es) 2010-07-15
UY31496A1 (es) 2009-07-17
US8822439B2 (en) 2014-09-02

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