MA31311B1 - Dérivés d'indazole substitués par oxadiazole, destinés à être utilisés comme agonistes de la sphingosine 1-phosphate (s1p) - Google Patents

Dérivés d'indazole substitués par oxadiazole, destinés à être utilisés comme agonistes de la sphingosine 1-phosphate (s1p)

Info

Publication number
MA31311B1
MA31311B1 MA32280A MA32280A MA31311B1 MA 31311 B1 MA31311 B1 MA 31311B1 MA 32280 A MA32280 A MA 32280A MA 32280 A MA32280 A MA 32280A MA 31311 B1 MA31311 B1 MA 31311B1
Authority
MA
Morocco
Prior art keywords
sphingosine
agonists
phosphate
indazole derivatives
substituted indazole
Prior art date
Application number
MA32280A
Other languages
Arabic (ar)
English (en)
Inventor
Mahmood Ahmed
Gerard Martin Paul Giblin
James Myatt
David Norton
Dean Andrew Rivers
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0707617A external-priority patent/GB0707617D0/en
Priority claimed from GB0805993A external-priority patent/GB0805993D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA31311B1 publication Critical patent/MA31311B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La présente invention porte sur des composés de formule (i) ou des sels de ceux-ci, ayant une activité pharmacologique, sur des procédés pour leur préparation, sur des compositions pharmaceutiques les contenant, et sur leur utilisation dans le traitement de divers troubles liés aux récepteurs de s1p1.
MA32280A 2007-04-19 2009-10-15 Dérivés d'indazole substitués par oxadiazole, destinés à être utilisés comme agonistes de la sphingosine 1-phosphate (s1p) MA31311B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0707617A GB0707617D0 (en) 2007-04-19 2007-04-19 Compounds
GB0805993A GB0805993D0 (en) 2008-04-02 2008-04-02 Compounds
PCT/EP2008/054647 WO2008128951A1 (fr) 2007-04-19 2008-04-17 Dérivés d'indazole substitués par oxadiazole, destinés à être utilisés comme agonistes de la sphingosine 1-phosphate (s1p)

Publications (1)

Publication Number Publication Date
MA31311B1 true MA31311B1 (fr) 2010-04-01

Family

ID=39604751

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32280A MA31311B1 (fr) 2007-04-19 2009-10-15 Dérivés d'indazole substitués par oxadiazole, destinés à être utilisés comme agonistes de la sphingosine 1-phosphate (s1p)

Country Status (25)

Country Link
US (1) US8324254B2 (fr)
EP (1) EP2137181B1 (fr)
JP (1) JP5313229B2 (fr)
KR (1) KR20090130062A (fr)
AR (1) AR066095A1 (fr)
AT (1) ATE500252T1 (fr)
AU (1) AU2008240773B2 (fr)
BR (1) BRPI0809472A2 (fr)
CA (1) CA2684385A1 (fr)
CL (1) CL2008001099A1 (fr)
CO (1) CO6321136A2 (fr)
CR (1) CR11119A (fr)
DE (1) DE602008005285D1 (fr)
DO (1) DOP2009000237A (fr)
EA (1) EA016443B1 (fr)
HK (1) HK1138001A1 (fr)
IL (1) IL200870A (fr)
JO (1) JO2686B1 (fr)
MA (1) MA31311B1 (fr)
MX (1) MX2009011155A (fr)
MY (1) MY146606A (fr)
NZ (1) NZ579595A (fr)
PE (1) PE20090150A1 (fr)
TW (1) TWI408137B (fr)
WO (1) WO2008128951A1 (fr)

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GB0910689D0 (en) * 2009-06-19 2009-08-05 Glaxo Wellcome Mfg Pte Ltd Novel compounds
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US20120283297A1 (en) * 2009-12-18 2012-11-08 Glaxo Wellcome House Oxadiazole substituted indazole derivatives for use as sphingosine 1-phosphate 1 (s1p1) receptor agonists
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SG10201501575VA (en) 2010-03-03 2015-04-29 Arena Pharm Inc Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
JP6209541B2 (ja) 2012-02-03 2017-10-04 ノバルティス アーゲー Ｎ−（４−シクロヘキシル−３−トリフルオロメチル−ベンジルオキシ）−アセトイミド酸エチルエステルの製造方法
JP2016028016A (ja) * 2012-12-12 2016-02-25 大日本住友製薬株式会社 オキサジアゾール誘導体とその医薬用途
CA2919980A1 (fr) * 2013-08-20 2015-02-26 Meiji Seika Pharma Co., Ltd. Methode d'evaluation et methode de depistage de l'agoniste du recepteur s1p1
CN116850181A (zh) 2015-01-06 2023-10-10 艾尼纳制药公司 治疗与s1p1受体有关的病症的方法
ES2929526T3 (es) 2015-06-22 2022-11-29 Arena Pharm Inc Sal cristalina de L-arginina del ácido (R)-2-(7-(4-ciclopentil-3-(trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclo-penta[b]indol-3-il)acético para su uso en trastornos asociados al receptor S1P1
CA3053416A1 (fr) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Composes et methodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
MA47504A (fr) 2017-02-16 2019-12-25 Arena Pharm Inc Composés et méthodes de traitement de l'angiocholite biliaire primitive
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Also Published As

Publication number Publication date
JP2010524886A (ja) 2010-07-22
AU2008240773A1 (en) 2008-10-30
EA016443B1 (ru) 2012-05-30
CL2008001099A1 (es) 2008-10-24
TW200911794A (en) 2009-03-16
JP5313229B2 (ja) 2013-10-09
TWI408137B (zh) 2013-09-11
BRPI0809472A2 (pt) 2014-09-09
US8324254B2 (en) 2012-12-04
KR20090130062A (ko) 2009-12-17
AU2008240773B2 (en) 2013-10-03
DOP2009000237A (es) 2010-05-31
PE20090150A1 (es) 2009-05-08
NZ579595A (en) 2012-06-29
US20100113528A1 (en) 2010-05-06
CO6321136A2 (es) 2011-09-20
MX2009011155A (es) 2009-10-30
CR11119A (es) 2010-01-18
AR066095A1 (es) 2009-07-22
JO2686B1 (en) 2013-03-03
WO2008128951A1 (fr) 2008-10-30
EP2137181A1 (fr) 2009-12-30
IL200870A0 (en) 2010-05-17
MY146606A (en) 2012-09-14
HK1138001A1 (en) 2010-08-13
EA200970967A1 (ru) 2010-02-26
IL200870A (en) 2013-08-29
ATE500252T1 (de) 2011-03-15
DE602008005285D1 (de) 2011-04-14
CA2684385A1 (fr) 2008-10-30
EP2137181B1 (fr) 2011-03-02

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