EA201000024A1 - Новые производные дикарбоновых кислот в качестве агонистов рецептора s1p1 - Google Patents

Новые производные дикарбоновых кислот в качестве агонистов рецептора s1p1

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Publication number
EA201000024A1
EA201000024A1 EA201000024A EA201000024A EA201000024A1 EA 201000024 A1 EA201000024 A1 EA 201000024A1 EA 201000024 A EA201000024 A EA 201000024A EA 201000024 A EA201000024 A EA 201000024A EA 201000024 A1 EA201000024 A1 EA 201000024A1
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EA
Eurasian Patent Office
Prior art keywords
new
acid derivatives
receptor agonists
dicarbonic acid
compounds
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EA201000024A
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English (en)
Other versions
EA018826B1 (ru
Inventor
Марк Капе
Никола Левоэн
Исабэль Берреби-Бертран
Филипп Робер
Жан-Шарль Шварц
Жанн-Мари Лёкомт
Джайрай Дилипбхаи Арадхие
Мутхукумаран Натараджан Пиллай
Бхавеш Моханбхай Панчал
Джигнеш Кантилал Дживани
Бисваджит Саманта
Ранджан Кумар Пал
Раджаманнар Тхеннати
Original Assignee
Биопроже
Сан Фарма Эдванст Рисерч Компани Лтд.
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Publication of EA201000024A1 publication Critical patent/EA201000024A1/ru
Publication of EA018826B1 publication Critical patent/EA018826B1/ru

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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
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Abstract

Настоящее изобретение относится к новым соединениям формулы (I), обладающим агонистической активностью в отношении рецепторов сфингозин-1-фосфата (S1P), способу их получения и их применению в качестве иммуносупрессивных агентов. Изобретение относится также к фармацевтическим композициям, содержащим эти соединения, и применению этих соединений для лечения/профилактики опосредуемых иммунитетом заболеваний и состояний или воспалительных заболеваний и состояний.
EA201000024A 2007-06-15 2008-06-16 Производные дикарбоновых кислот в качестве агонистов рецептора s1p1 EA018826B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07290748A EP2014653A1 (en) 2007-06-15 2007-06-15 Novel dicarboxylic acid derivatives as S1P1 receptor agonists
PCT/EP2008/057571 WO2008152149A1 (en) 2007-06-15 2008-06-16 Novel dicarboxylic acid derivatives as s1p1 receptor agonists

Publications (2)

Publication Number Publication Date
EA201000024A1 true EA201000024A1 (ru) 2010-06-30
EA018826B1 EA018826B1 (ru) 2013-11-29

Family

ID=38645817

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Application Number Title Priority Date Filing Date
EA201000024A EA018826B1 (ru) 2007-06-15 2008-06-16 Производные дикарбоновых кислот в качестве агонистов рецептора s1p1

Country Status (17)

Country Link
US (1) US8809539B2 (ru)
EP (2) EP2014653A1 (ru)
JP (1) JP5346016B2 (ru)
KR (1) KR20100040853A (ru)
CN (1) CN101784535A (ru)
BR (1) BRPI0811712A2 (ru)
CA (1) CA2693126A1 (ru)
CO (1) CO6251262A2 (ru)
EA (1) EA018826B1 (ru)
IL (1) IL202741A0 (ru)
MA (1) MA31447B1 (ru)
MX (1) MX2009013733A (ru)
NZ (1) NZ581933A (ru)
TN (1) TN2009000524A1 (ru)
UA (1) UA99132C2 (ru)
WO (1) WO2008152149A1 (ru)
ZA (1) ZA200908851B (ru)

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BRPI0817597A2 (pt) 2007-10-04 2015-04-07 Merck Serono Sa Compostos de diarila de oxadiazol, processo para sua preparação, composições farmacêuticas e kit compreendendo os mesmos, bem como seus usos
CA2703987A1 (en) * 2007-11-08 2009-05-14 Pfizer Inc. Cyclobutyl carboxylic acid derivatives
HUE030424T2 (en) 2008-07-23 2017-05-29 Arena Pharm Inc Substituted 1,2,3,4-tetrahydrocyclopenta [b] indol-3-ylacetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
ES2583630T3 (es) 2008-08-27 2016-09-21 Arena Pharmaceuticals, Inc. Derivados de ácido tricíclico sustituido como agonistas del receptor S1P1 útiles en el tratamiento de trastornos autoinmunes e inflamatorios
CA2740484C (en) * 2008-10-17 2021-09-21 Akaal Pharma Pty Ltd S1p receptors modulators and their use thereof
WO2010042998A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
EP2241558A1 (en) * 2009-04-03 2010-10-20 Merck Serono SA Oxadiazole derivatives
WO2011048409A1 (en) 2009-10-20 2011-04-28 Astrazeneca Ab Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
CN103221391B (zh) 2010-01-27 2018-07-06 艾尼纳制药公司 (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法
JP2013521301A (ja) 2010-03-03 2013-06-10 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１ｐ１受容体修飾物質およびその結晶形の調製のためのプロセス
EP2560969B1 (en) * 2010-04-23 2015-08-12 Bristol-Myers Squibb Company 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists
CA2797668A1 (en) 2010-04-27 2011-11-03 Allergan, Inc. 3-(4-((1h-imidazol-1-yl)methyl)phenyl)-5-aryl-1,2,4-oxadiazole derivatives as sphingosine-1 phosphate receptors modulators
PT2592933T (pt) 2010-07-16 2017-05-23 Gaweco Anderson Inibidores de mif e suas utilizações
US8822510B2 (en) 2010-07-20 2014-09-02 Bristol-Myers Squibb Company Substituted 3-phenyl-1,2,4-Oxadiazole compounds
US20120214848A1 (en) * 2011-02-18 2012-08-23 Abbott Laboratories [1,2,4]oxadiazol-3-yl acid salts and crystalline forms and their preparation
EP2511275A1 (en) * 2011-04-12 2012-10-17 Bioprojet Novel piperidinyl monocarboxylic acids as S1P1 receptor agonists
CN107405332A (zh) 2015-01-06 2017-11-28 艾尼纳制药公司 治疗与s1p1受体有关的病症的方法
US10301262B2 (en) 2015-06-22 2019-05-28 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders
WO2018119080A1 (en) * 2016-12-21 2018-06-28 Cornell University Compositions and methods for treating hepatic disorders
EP3582772A1 (en) 2017-02-16 2019-12-25 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
MA47503A (fr) 2017-02-16 2021-04-21 Arena Pharm Inc Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
CN107827837B (zh) * 2017-11-21 2021-09-24 苏州朗科生物技术股份有限公司 鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用
SG11202006255UA (en) * 2018-02-02 2020-07-29 Univ Kyoto Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability
EP3847158A1 (en) 2018-09-06 2021-07-14 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
CN111803636B (zh) * 2020-07-22 2022-08-30 四川大学 1-磷酸鞘氨醇受体1作为microRNA-9调控血管生成的药物靶点的应用
RU2765464C1 (ru) * 2021-05-20 2022-01-31 Федеральное государственное бюджетное учреждение науки Институт органической химии им. Н.Д. Зеленского Российской академии наук (ИОХ РАН) Способ получения эфиров пиперидин-4,4-дикарбоновых кислот
JP7464075B2 (ja) 2022-04-20 2024-04-09 株式会社大林組 プレストレス構造及びそれを用いたプレキャストコンクリート部材

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DE602004014277D1 (de) * 2004-10-22 2008-07-17 Bioprojet Soc Civ Neue Dicarbonsäurederivate

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BRPI0811712A2 (pt) 2014-11-04
US20100249187A1 (en) 2010-09-30
MA31447B1 (fr) 2010-06-01
CO6251262A2 (es) 2011-02-21
EP2170850B1 (en) 2014-09-24
AU2008263817A1 (en) 2008-12-18
TN2009000524A1 (en) 2011-03-31
ZA200908851B (en) 2010-07-28
EP2170850A1 (en) 2010-04-07
CA2693126A1 (en) 2008-12-18
US8809539B2 (en) 2014-08-19
EP2014653A1 (en) 2009-01-14
JP2010529977A (ja) 2010-09-02
UA99132C2 (ru) 2012-07-25
CN101784535A (zh) 2010-07-21
JP5346016B2 (ja) 2013-11-20
EA018826B1 (ru) 2013-11-29
IL202741A0 (en) 2010-06-30
WO2008152149A1 (en) 2008-12-18
NZ581933A (en) 2012-01-12
MX2009013733A (es) 2010-04-22
KR20100040853A (ko) 2010-04-21

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