PL2370441T3 - Arylocykloheksyloetery dihydrotetraazabenzoazulenów do stosowania jako antagoniści receptora v1a wazopresyny - Google Patents

Arylocykloheksyloetery dihydrotetraazabenzoazulenów do stosowania jako antagoniści receptora v1a wazopresyny

Info

Publication number
PL2370441T3
PL2370441T3 PL09752380T PL09752380T PL2370441T3 PL 2370441 T3 PL2370441 T3 PL 2370441T3 PL 09752380 T PL09752380 T PL 09752380T PL 09752380 T PL09752380 T PL 09752380T PL 2370441 T3 PL2370441 T3 PL 2370441T3
Authority
PL
Poland
Prior art keywords
dihydrotetraazabenzoazulenes
arylcyclohexylethers
vasopressin
receptor antagonists
antagonists
Prior art date
Application number
PL09752380T
Other languages
English (en)
Inventor
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PL2370441T3 publication Critical patent/PL2370441T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
PL09752380T 2008-11-28 2009-11-18 Arylocykloheksyloetery dihydrotetraazabenzoazulenów do stosowania jako antagoniści receptora v1a wazopresyny PL2370441T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08170188 2008-11-28
PCT/EP2009/065354 WO2010060836A1 (en) 2008-11-28 2009-11-18 Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
EP09752380.7A EP2370441B1 (en) 2008-11-28 2009-11-18 Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin v1a receptor antagonists

Publications (1)

Publication Number Publication Date
PL2370441T3 true PL2370441T3 (pl) 2014-02-28

Family

ID=41382009

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09752380T PL2370441T3 (pl) 2008-11-28 2009-11-18 Arylocykloheksyloetery dihydrotetraazabenzoazulenów do stosowania jako antagoniści receptora v1a wazopresyny

Country Status (32)

Country Link
US (2) US8227458B2 (pl)
EP (1) EP2370441B1 (pl)
JP (1) JP5452608B2 (pl)
KR (1) KR101359742B1 (pl)
CN (1) CN102227428B (pl)
AR (2) AR074409A1 (pl)
AU (1) AU2009319123B2 (pl)
BR (1) BRPI0922303B1 (pl)
CA (1) CA2743976C (pl)
CO (1) CO6341478A2 (pl)
CR (1) CR20110220A (pl)
CY (1) CY1115435T1 (pl)
DK (1) DK2370441T3 (pl)
EC (1) ECSP11011089A (pl)
ES (1) ES2431279T3 (pl)
HK (1) HK1160642A1 (pl)
HR (1) HRP20131067T1 (pl)
IL (1) IL212122A (pl)
MA (1) MA32781B1 (pl)
MX (1) MX2011005596A (pl)
MY (1) MY150837A (pl)
NZ (1) NZ592076A (pl)
PE (1) PE20110582A1 (pl)
PL (1) PL2370441T3 (pl)
PT (1) PT2370441E (pl)
RU (1) RU2507205C2 (pl)
SG (1) SG171846A1 (pl)
SI (1) SI2370441T1 (pl)
TW (1) TWI379833B (pl)
UA (1) UA103504C2 (pl)
WO (1) WO2010060836A1 (pl)
ZA (1) ZA201103419B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8952037B2 (en) 2010-05-13 2015-02-10 Amgen Inc. Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors
US8828989B2 (en) * 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
WO2013050334A1 (en) * 2011-10-05 2013-04-11 F. Hoffmann-La Roche Ag Cyclohexyl-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenes as v1a antagonists
WO2015024819A1 (en) * 2013-08-19 2015-02-26 F. Hoffmann-La Roche Ag V1a antagonists to treat phase shift sleep disorders
NZ720340A (en) 2013-12-05 2020-03-27 Hoffmann La Roche Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crystalline forms thereof
WO2017191117A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft V1a receptor antagonists for use in the treatment of renal diseases
RU2666598C1 (ru) * 2017-07-14 2018-09-11 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Средство для коррекции расстройств аутистического спектра
US11033601B2 (en) 2017-09-14 2021-06-15 The Regents Of The University Of Colorado, A Body Corporate Selective inhibition of V1b for treating fatty liver
AU2018379448A1 (en) * 2017-12-08 2020-03-12 F. Hoffmann-La Roche Ag Pharmaceutical formulation
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
WO2020139670A1 (en) 2018-12-27 2020-07-02 Teva Pharmaceuticals International Gmbh Solid state forms of balovaptan

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
US5521173A (en) 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
EP1147115B3 (en) * 1999-01-19 2008-12-24 Ortho-McNeil Pharmaceutical, Inc. Tricyclic benzodiazepines as vasopressin receptor antagonists
TWI239333B (en) * 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
GB0303852D0 (en) 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
GB0400700D0 (en) * 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
CA2568056A1 (en) * 2004-05-25 2005-12-08 Pfizer Products Inc. Tetraazabenzo[e]azulene derivatives and analogs thereof
KR100840852B1 (ko) 2004-05-25 2008-06-23 화이자 프로덕츠 인크. 테트라아자벤조[ｅ]아줄렌 유도체 및 이의 유사체
EP1632494A1 (en) 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonists
JP2008510789A (ja) 2004-08-25 2008-04-10 ファイザー・インク トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用
US20080188478A1 (en) 2005-04-26 2008-08-07 Pfizer Inc. Compounds Useful In Therapy
US20080234252A1 (en) 2005-05-18 2008-09-25 Pfizer Inc Compounds Useful in Therapy
ES2376378T3 (es) 2007-01-12 2012-03-13 F. Hoffmann-La Roche Ag Derivados de espiropiperidina-glicinamida.
US8617703B2 (en) * 2008-04-09 2013-12-31 Kuraray Co., Ltd. Gas barrier layered product and method for producing the same
BRPI0921110A2 (pt) 2008-11-13 2016-02-16 Hoffmann La Roche espiro-5,6-di-hidro-4h-2,3,5,10b-tetraaza-benzo[e]azulenos
WO2010057795A1 (en) 2008-11-18 2010-05-27 F. Hoffmann-La Roche Ag Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) * 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) * 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) * 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes

Also Published As

Publication number Publication date
HRP20131067T1 (hr) 2013-12-06
IL212122A (en) 2013-06-27
US20100137286A1 (en) 2010-06-03
EP2370441B1 (en) 2013-09-11
UA103504C2 (ru) 2013-10-25
AU2009319123A1 (en) 2010-06-03
AR074409A1 (es) 2011-01-12
EP2370441A1 (en) 2011-10-05
MY150837A (en) 2014-02-28
MX2011005596A (es) 2011-06-16
IL212122A0 (en) 2011-06-30
ES2431279T3 (es) 2013-11-25
WO2010060836A1 (en) 2010-06-03
DK2370441T3 (da) 2013-10-21
PT2370441E (pt) 2013-11-14
CO6341478A2 (es) 2011-11-21
RU2507205C2 (ru) 2014-02-20
MA32781B1 (fr) 2011-11-01
KR20110077022A (ko) 2011-07-06
ECSP11011089A (es) 2011-06-30
AR112338A2 (es) 2019-10-16
CA2743976C (en) 2017-02-21
SG171846A1 (en) 2011-07-28
US20120225865A1 (en) 2012-09-06
BRPI0922303B1 (pt) 2019-11-12
JP2012510441A (ja) 2012-05-10
PE20110582A1 (es) 2011-08-17
CR20110220A (es) 2011-06-21
US8227458B2 (en) 2012-07-24
CY1115435T1 (el) 2017-01-04
CN102227428A (zh) 2011-10-26
TW201024300A (en) 2010-07-01
RU2011123703A (ru) 2013-01-10
CA2743976A1 (en) 2010-06-03
TWI379833B (en) 2012-12-21
CN102227428B (zh) 2015-03-25
JP5452608B2 (ja) 2014-03-26
AU2009319123B2 (en) 2014-10-23
KR101359742B1 (ko) 2014-02-06
HK1160642A1 (en) 2012-08-10
US8461152B2 (en) 2013-06-11
NZ592076A (en) 2012-06-29
BRPI0922303A2 (pt) 2016-01-12
ZA201103419B (en) 2014-07-30
SI2370441T1 (sl) 2013-12-31

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