BRPI0514458A - triazolbenzodiazepinas e seu uso como antagonistas de vasopressina - Google Patents
triazolbenzodiazepinas e seu uso como antagonistas de vasopressinaInfo
- Publication number
- BRPI0514458A BRPI0514458A BRPI0514458-2A BRPI0514458A BRPI0514458A BR PI0514458 A BRPI0514458 A BR PI0514458A BR PI0514458 A BRPI0514458 A BR PI0514458A BR PI0514458 A BRPI0514458 A BR PI0514458A
- Authority
- BR
- Brazil
- Prior art keywords
- premature
- ring
- alkyl
- vasopressin antagonists
- triazolbenzodiazepines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
TRIAZOLBENZODIAZEPINAS E SEU USO COMO ANTAGONISTAS DE VASOPRESSINA Compostos de fórmula (I), ou derivados farmaceuticamente aceitáveis destes, em que R representa H, alquila C~ 1~-6~, SO~ 2~R¬ 1¬, SO~ 2~NR¬ 1¬R¬ 2¬, ou COR¬ 1¬; R¬ 1¬ e R¬ 2¬ representam, independentemente, alquila C~ 1-6~; e o anel A representa um anel fenila ou um anel piridinila, podem ser úteis no tratamento de ansiedade, doença cardiovascular (incluindo angina, aterosclerose, hipertensão, insuficiência cardíaca, edema, hipernatremia), dismenorréia, (primária e secundária), endometriose, êmese (incluindo cinetose), crescimento intra-uterino retardado, inflamação (incluindo artrite reumatólde), dor intermenstrual, pré-eclâmpsia, ejaculação precoce, trabalho de parto prematuro (antes do tempo) e doença de Raynaud.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0418980A GB0418980D0 (en) | 2004-08-25 | 2004-08-25 | Triazole compounds useful in therapy |
US61660104P | 2004-10-05 | 2004-10-05 | |
PCT/IB2005/002711 WO2006021882A1 (en) | 2004-08-25 | 2005-08-12 | Triazolobenzodiazepines and their use as vasopressin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0514458A true BRPI0514458A (pt) | 2008-06-10 |
Family
ID=35355092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0514458-2A BRPI0514458A (pt) | 2004-08-25 | 2005-08-12 | triazolbenzodiazepinas e seu uso como antagonistas de vasopressina |
Country Status (7)
Country | Link |
---|---|
US (1) | US7456170B2 (pt) |
EP (1) | EP1784408A1 (pt) |
JP (1) | JP2008510789A (pt) |
BR (1) | BRPI0514458A (pt) |
CA (1) | CA2578370A1 (pt) |
MX (1) | MX2007002248A (pt) |
WO (1) | WO2006021882A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2356123T1 (sl) * | 2008-11-13 | 2013-01-31 | F. Hoffmann-La Roche Ag | Piro-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo(e)azuleni |
SG171742A1 (en) * | 2008-11-18 | 2011-07-28 | Hoffmann La Roche | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
EP2370441B1 (en) | 2008-11-28 | 2013-09-11 | F. Hoffmann-La Roche AG | Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin v1a receptor antagonists |
US8420633B2 (en) * | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) * | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) * | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
US8828989B2 (en) * | 2011-09-26 | 2014-09-09 | Hoffmann-La Roche Inc. | Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists |
MX350844B (es) | 2012-03-06 | 2017-09-22 | Pfizer | Derivados macrocíclicos para el tratamiento de enfermedades proliferativas. |
CN105492010B (zh) * | 2013-08-19 | 2020-01-03 | 豪夫迈·罗氏有限公司 | 用于治疗相移睡眠障碍的V1a拮抗剂 |
MX2016006558A (es) | 2013-12-05 | 2016-08-03 | Hoffmann La Roche | Sistesis de trans-8-cloro-5-metil-1-[4-(piridin-2-iloxi)-ciclohexi l]-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo[e]azuleno y formas cristalinas del mismo. |
TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素V1a受體拮抗劑之三環化合物 |
HU231206B1 (hu) * | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999006409A1 (en) * | 1997-07-30 | 1999-02-11 | American Home Products Corporation | Tricyclic vasopressin agonists |
MXPA04007995A (es) * | 2002-02-19 | 2004-11-26 | Teva Pharma | Desolvatacion de solvatos de hemicalcio de atorvastatina. |
US7119088B2 (en) * | 2003-02-19 | 2006-10-10 | Pfizer Inc. | Triazole compounds useful in therapy |
GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
-
2005
- 2005-08-12 MX MX2007002248A patent/MX2007002248A/es unknown
- 2005-08-12 BR BRPI0514458-2A patent/BRPI0514458A/pt not_active IP Right Cessation
- 2005-08-12 US US11/570,694 patent/US7456170B2/en not_active Expired - Fee Related
- 2005-08-12 CA CA002578370A patent/CA2578370A1/en not_active Abandoned
- 2005-08-12 WO PCT/IB2005/002711 patent/WO2006021882A1/en active Application Filing
- 2005-08-12 JP JP2007529032A patent/JP2008510789A/ja not_active Withdrawn
- 2005-08-12 EP EP05781153A patent/EP1784408A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1784408A1 (en) | 2007-05-16 |
US7456170B2 (en) | 2008-11-25 |
MX2007002248A (es) | 2008-10-02 |
JP2008510789A (ja) | 2008-04-10 |
US20070249585A1 (en) | 2007-10-25 |
CA2578370A1 (en) | 2006-03-02 |
WO2006021882A1 (en) | 2006-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |