HRP20050070B1 - 3-2-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2-indolinon-monoetansulfonat i njegova primjena kao farmaceutskog pripravka - Google Patents

3-2-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2-indolinon-monoetansulfonat i njegova primjena kao farmaceutskog pripravka

Info

Publication number
HRP20050070B1
HRP20050070B1 HRP20050070AA HRP20050070A HRP20050070B1 HR P20050070 B1 HRP20050070 B1 HR P20050070B1 HR P20050070A A HRP20050070A A HR P20050070AA HR P20050070 A HRP20050070 A HR P20050070A HR P20050070 B1 HRP20050070 B1 HR P20050070B1
Authority
HR
Croatia
Prior art keywords
methyl
methylcarbonyl
anilino
piperazin
methylene
Prior art date
Application number
HRP20050070AA
Other languages
English (en)
Inventor
Gerald Jürgen ROTH
Günter Linz
Peter Sieger
Werner Rall
Frank Hilberg
Thomas Bock
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30469050&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20050070(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg
Publication of HRP20050070A2 publication Critical patent/HRP20050070A2/xx
Publication of HRP20050070B1 publication Critical patent/HRP20050070B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Prikazani izum se odnosi na spoj 3-Z-[1-(4-(N-((4-metil-piperazin-1-il)-metilkarbonil)-N-metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2-indolinon monoetansulfonat formule I i njegovu primjenu u farmaceutskom pripravku. Formula I:
HRP20050070AA 2002-07-24 2005-01-21 3-2-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2-indolinon-monoetansulfonat i njegova primjena kao farmaceutskog pripravka HRP20050070B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10233500A DE10233500A1 (de) 2002-07-24 2002-07-24 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
PCT/EP2003/007822 WO2004013099A1 (en) 2002-07-24 2003-07-18 3-z-[1-(4-(n-((4-methyl-piperazin-1-yl)-methylcarbonyl)-n-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition

Publications (2)

Publication Number Publication Date
HRP20050070A2 HRP20050070A2 (en) 2005-12-31
HRP20050070B1 true HRP20050070B1 (hr) 2013-09-30

Family

ID=30469050

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20050070AA HRP20050070B1 (hr) 2002-07-24 2005-01-21 3-2-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2-indolinon-monoetansulfonat i njegova primjena kao farmaceutskog pripravka

Country Status (36)

Country Link
US (2) US7119093B2 (hr)
EP (2) EP2386543A1 (hr)
JP (1) JP5039279B2 (hr)
KR (1) KR101145691B1 (hr)
CN (1) CN100351235C (hr)
AR (2) AR040662A1 (hr)
AT (1) ATE551322T1 (hr)
AU (1) AU2003254376B2 (hr)
BR (1) BRPI0312811B8 (hr)
CA (1) CA2493310C (hr)
CY (1) CY1112916T1 (hr)
DE (1) DE10233500A1 (hr)
DK (1) DK1527047T3 (hr)
EA (1) EA008684B1 (hr)
EC (1) ECSP055571A (hr)
EG (1) EG24562A (hr)
ES (1) ES2384968T3 (hr)
HK (1) HK1078851A1 (hr)
HR (1) HRP20050070B1 (hr)
IL (2) IL166405A0 (hr)
ME (1) ME00353B (hr)
MX (1) MXPA04012785A (hr)
MY (1) MY136883A (hr)
NO (1) NO330486B1 (hr)
NZ (1) NZ538367A (hr)
PE (1) PE20040704A1 (hr)
PL (1) PL223758B1 (hr)
PT (1) PT1527047E (hr)
RS (1) RS52283B (hr)
SA (1) SA03240446B1 (hr)
SI (1) SI1527047T1 (hr)
TW (1) TWI285635B (hr)
UA (1) UA78352C2 (hr)
UY (1) UY27904A1 (hr)
WO (1) WO2004013099A1 (hr)
ZA (1) ZA200409814B (hr)

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ATE551322T1 (de) 2012-04-15
EG24562A (en) 2009-10-25
JP2005535684A (ja) 2005-11-24
TWI285635B (en) 2007-08-21
UY27904A1 (es) 2004-02-27
NZ538367A (en) 2008-01-31
MY136883A (en) 2008-11-28
AU2003254376B2 (en) 2010-06-17
AU2003254376A1 (en) 2004-02-23
US7119093B2 (en) 2006-10-10
EP1527047A1 (en) 2005-05-04
CA2493310C (en) 2011-01-18
BRPI0312811B8 (pt) 2021-05-25
ECSP055571A (es) 2005-04-18
CN1671660A (zh) 2005-09-21
AR094217A2 (es) 2015-07-15
WO2004013099A1 (en) 2004-02-12
CA2493310A1 (en) 2004-02-12
BR0312811A (pt) 2005-04-19
DE10233500A1 (de) 2004-02-19
KR20050042139A (ko) 2005-05-04
US20060258681A1 (en) 2006-11-16
PE20040704A1 (es) 2004-11-29
PL223758B1 (pl) 2016-10-31
EA008684B1 (ru) 2007-06-29
BRPI0312811B1 (pt) 2019-03-12
JP5039279B2 (ja) 2012-10-03
HRP20050070A2 (en) 2005-12-31
SI1527047T1 (sl) 2012-07-31
PL372996A1 (en) 2005-08-08
MEP53708A (hr) 2011-05-10
DK1527047T3 (da) 2012-07-16
TW200409754A (en) 2004-06-16
EP2386543A1 (en) 2011-11-16
RS52283B (sr) 2012-10-31
NO330486B1 (no) 2011-04-26
RS20050046A (en) 2007-09-21
US20040176392A1 (en) 2004-09-09
CY1112916T1 (el) 2016-04-13
BRPI0312811A8 (pt) 2019-01-02
HK1078851A1 (en) 2006-03-24
IL166405A (en) 2009-11-18
EP1527047B1 (en) 2012-03-28
KR101145691B1 (ko) 2012-05-25
IL166405A0 (en) 2006-01-15
SA03240446B1 (ar) 2007-07-31
EA200500146A1 (ru) 2005-08-25
MXPA04012785A (es) 2005-06-08
AR040662A1 (es) 2005-04-13
PT1527047E (pt) 2012-06-28
UA78352C2 (uk) 2007-03-15
ES2384968T3 (es) 2012-07-16
CN100351235C (zh) 2007-11-28
ME00353B (me) 2011-10-10
ZA200409814B (en) 2006-02-22
NO20050985L (no) 2005-02-23

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