ME00353B - 3-z-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2-indolinon-monoetansulfonat i njegova primena u farmaceutskoj kompoziciji - Google Patents

3-z-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2-indolinon-monoetansulfonat i njegova primena u farmaceutskoj kompoziciji

Info

Publication number
ME00353B
ME00353B MEP-2008-537A MEP53708A ME00353B ME 00353 B ME00353 B ME 00353B ME P53708 A MEP53708 A ME P53708A ME 00353 B ME00353 B ME 00353B
Authority
ME
Montenegro
Prior art keywords
methyl
methylcarbonyl
anilino
piperazin
methoxycarbonyl
Prior art date
Application number
MEP-2008-537A
Other languages
English (en)
French (fr)
Inventor
Peter Sieger
Gerald Juergen Roth
Guenter Linz
Werner Rall
Frank Hilberg
Thomas Bock
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30469050&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME00353(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP53708A publication Critical patent/MEP53708A/xx
Publication of ME00353B publication Critical patent/ME00353B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Ovaj pronalazak odnosi se na jedinjenje 3-Z-[l-(4-(N-((4-metil-piperazin-l-il)-metilkarbonil)-N-metil-amino)-anilino)-l-fenil-metilen]-6-metoksikarbonil-2-indolinon-monoetansulfonat, formule I, i na njegovu primenu u farmaceutskoj kompoziciji.
MEP-2008-537A 2002-07-24 2003-07-18 3-z-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2-indolinon-monoetansulfonat i njegova primena u farmaceutskoj kompoziciji ME00353B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10233500A DE10233500A1 (de) 2002-07-24 2002-07-24 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
PCT/EP2003/007822 WO2004013099A1 (en) 2002-07-24 2003-07-18 3-z-[1-(4-(n-((4-methyl-piperazin-1-yl)-methylcarbonyl)-n-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition
YU20050046A RS52283B (sr) 2002-07-24 2003-07-18 3-z-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n- metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2- indolinon-monoetansulfonat i njegova primena u farmaceutskoj kompoziciji

Publications (2)

Publication Number Publication Date
MEP53708A MEP53708A (en) 2011-05-10
ME00353B true ME00353B (me) 2011-10-10

Family

ID=30469050

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-537A ME00353B (me) 2002-07-24 2003-07-18 3-z-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2-indolinon-monoetansulfonat i njegova primena u farmaceutskoj kompoziciji

Country Status (36)

Country Link
US (2) US7119093B2 (me)
EP (2) EP1527047B1 (me)
JP (1) JP5039279B2 (me)
KR (1) KR101145691B1 (me)
CN (1) CN100351235C (me)
AR (2) AR040662A1 (me)
AT (1) ATE551322T1 (me)
AU (1) AU2003254376B2 (me)
BR (1) BRPI0312811B8 (me)
CA (1) CA2493310C (me)
CY (1) CY1112916T1 (me)
DE (1) DE10233500A1 (me)
DK (1) DK1527047T3 (me)
EA (1) EA008684B1 (me)
EC (1) ECSP055571A (me)
EG (1) EG24562A (me)
ES (1) ES2384968T3 (me)
HK (1) HK1078851A1 (me)
HR (1) HRP20050070B1 (me)
IL (2) IL166405A0 (me)
ME (1) ME00353B (me)
MX (1) MXPA04012785A (me)
MY (1) MY136883A (me)
NO (1) NO330486B1 (me)
NZ (1) NZ538367A (me)
PE (1) PE20040704A1 (me)
PL (1) PL223758B1 (me)
PT (1) PT1527047E (me)
RS (1) RS52283B (me)
SA (1) SA03240446B1 (me)
SI (1) SI1527047T1 (me)
TW (1) TWI285635B (me)
UA (1) UA78352C2 (me)
UY (1) UY27904A1 (me)
WO (1) WO2004013099A1 (me)
ZA (1) ZA200409814B (me)

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IL166405A (en) 2009-11-18
UY27904A1 (es) 2004-02-27
BRPI0312811A8 (pt) 2019-01-02
EG24562A (en) 2009-10-25
TWI285635B (en) 2007-08-21
NO20050985L (no) 2005-02-23
MEP53708A (en) 2011-05-10
KR20050042139A (ko) 2005-05-04
CY1112916T1 (el) 2016-04-13
TW200409754A (en) 2004-06-16
PE20040704A1 (es) 2004-11-29
ECSP055571A (es) 2005-04-18
US20040176392A1 (en) 2004-09-09
SA03240446B1 (ar) 2007-07-31
JP5039279B2 (ja) 2012-10-03
EP1527047A1 (en) 2005-05-04
MXPA04012785A (es) 2005-06-08
EP1527047B1 (en) 2012-03-28
HRP20050070B1 (hr) 2013-09-30
CA2493310A1 (en) 2004-02-12
US20060258681A1 (en) 2006-11-16
CN1671660A (zh) 2005-09-21
UA78352C2 (uk) 2007-03-15
HK1078851A1 (en) 2006-03-24
DK1527047T3 (da) 2012-07-16
KR101145691B1 (ko) 2012-05-25
AU2003254376B2 (en) 2010-06-17
MY136883A (en) 2008-11-28
IL166405A0 (en) 2006-01-15
EP2386543A1 (en) 2011-11-16
PL372996A1 (en) 2005-08-08
NZ538367A (en) 2008-01-31
BRPI0312811B1 (pt) 2019-03-12
EA200500146A1 (ru) 2005-08-25
AR040662A1 (es) 2005-04-13
EA008684B1 (ru) 2007-06-29
CA2493310C (en) 2011-01-18
RS52283B (sr) 2012-10-31
RS20050046A (en) 2007-09-21
WO2004013099A1 (en) 2004-02-12
CN100351235C (zh) 2007-11-28
AU2003254376A1 (en) 2004-02-23
PL223758B1 (pl) 2016-10-31
PT1527047E (pt) 2012-06-28
JP2005535684A (ja) 2005-11-24
SI1527047T1 (sl) 2012-07-31
ZA200409814B (en) 2006-02-22
AR094217A2 (es) 2015-07-15
US7119093B2 (en) 2006-10-10
NO330486B1 (no) 2011-04-26
HRP20050070A2 (en) 2005-12-31
BR0312811A (pt) 2005-04-19
ATE551322T1 (de) 2012-04-15
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BRPI0312811B8 (pt) 2021-05-25
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