CO6341478A2 - Arilciclohexileteres de dihidro-tetraazabenzoazulenos para su uso como antagonistas del receptor v1a de vasopresina - Google Patents

Arilciclohexileteres de dihidro-tetraazabenzoazulenos para su uso como antagonistas del receptor v1a de vasopresina

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Publication number
CO6341478A2
CO6341478A2 CO11039945A CO11039945A CO6341478A2 CO 6341478 A2 CO6341478 A2 CO 6341478A2 CO 11039945 A CO11039945 A CO 11039945A CO 11039945 A CO11039945 A CO 11039945A CO 6341478 A2 CO6341478 A2 CO 6341478A2
Authority
CO
Colombia
Prior art keywords
dihydro
arylcyclohexyl
ethers
receptor
vasopresine
Prior art date
Application number
CO11039945A
Other languages
English (en)
Inventor
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO6341478A2 publication Critical patent/CO6341478A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se refiere a derivados de arilciclohexiléteres de dihidro-tetraazabenzoazuleno es decir, derivados de arilciclohexiléteres de 5,6-dihidro-4H-2,3,5,10b-tetraaza-benzo(e)azuleno de la fórmula Ien la que R1, R2 y R3 tienen los significados aquí descritos.Los compuestos de la invención actúan como moduladores del receptor de la V1a y en particular como antagonistas del receptor de la V1a; la invención se refiere además a su obtención, a composiciones farmacéuticas que los contienen y a su utilización como medicamentos. Los compuestos activos de la presente invención son útiles como agentes terapéuticos que actúan a nivel periférico y central en los estados patológicos tales como la dismenorrea, disfunción sexual masculina o femenina, hipertensión, fallo cardiaco crónico, secreción inapropiada de vasopresina, cirrosis hepática, síndrome nefrótico, ansiedad, trastornos depresivos, trastorno obsesivo-compulsivo, trastornos del espectro autista, esquizofrenia y comportamiento agresivo.
CO11039945A 2008-11-28 2011-03-31 Arilciclohexileteres de dihidro-tetraazabenzoazulenos para su uso como antagonistas del receptor v1a de vasopresina CO6341478A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08170188 2008-11-28

Publications (1)

Publication Number Publication Date
CO6341478A2 true CO6341478A2 (es) 2011-11-21

Family

ID=41382009

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11039945A CO6341478A2 (es) 2008-11-28 2011-03-31 Arilciclohexileteres de dihidro-tetraazabenzoazulenos para su uso como antagonistas del receptor v1a de vasopresina

Country Status (32)

Country Link
US (2) US8227458B2 (es)
EP (1) EP2370441B1 (es)
JP (1) JP5452608B2 (es)
KR (1) KR101359742B1 (es)
CN (1) CN102227428B (es)
AR (2) AR074409A1 (es)
AU (1) AU2009319123B2 (es)
BR (1) BRPI0922303B1 (es)
CA (1) CA2743976C (es)
CO (1) CO6341478A2 (es)
CR (1) CR20110220A (es)
CY (1) CY1115435T1 (es)
DK (1) DK2370441T3 (es)
EC (1) ECSP11011089A (es)
ES (1) ES2431279T3 (es)
HK (1) HK1160642A1 (es)
HR (1) HRP20131067T1 (es)
IL (1) IL212122A (es)
MA (1) MA32781B1 (es)
MX (1) MX2011005596A (es)
MY (1) MY150837A (es)
NZ (1) NZ592076A (es)
PE (1) PE20110582A1 (es)
PL (1) PL2370441T3 (es)
PT (1) PT2370441E (es)
RU (1) RU2507205C2 (es)
SG (1) SG171846A1 (es)
SI (1) SI2370441T1 (es)
TW (1) TWI379833B (es)
UA (1) UA103504C2 (es)
WO (1) WO2010060836A1 (es)
ZA (1) ZA201103419B (es)

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US8828989B2 (en) * 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
KR20140082765A (ko) * 2011-10-05 2014-07-02 에프. 호프만-라 로슈 아게 V1a 길항제로서의 사이클로헥실-4H,6H-5-옥사-2,3,10b-트라이아자-벤조[e]아줄렌
PL3035939T3 (pl) * 2013-08-19 2020-07-27 F. Hoffmann-La Roche Ag Antagoniści V1a do leczenia zaburzeń snu z przesunięciem faz snu
AU2014359409A1 (en) * 2013-12-05 2016-05-19 F. Hoffmann-La Roche Ag Synthesis of trans-8-chloro-5-methyl-1 -[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof
WO2017191117A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft V1a receptor antagonists for use in the treatment of renal diseases
RU2666598C1 (ru) * 2017-07-14 2018-09-11 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Средство для коррекции расстройств аутистического спектра
US11033601B2 (en) 2017-09-14 2021-06-15 The Regents Of The University Of Colorado, A Body Corporate Selective inhibition of V1b for treating fatty liver
TWI816718B (zh) 2017-12-08 2023-10-01 瑞士商赫孚孟拉羅股份公司 醫藥調配物
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
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Also Published As

Publication number Publication date
CY1115435T1 (el) 2017-01-04
RU2507205C2 (ru) 2014-02-20
KR101359742B1 (ko) 2014-02-06
CA2743976A1 (en) 2010-06-03
AU2009319123A1 (en) 2010-06-03
KR20110077022A (ko) 2011-07-06
AR112338A2 (es) 2019-10-16
EP2370441A1 (en) 2011-10-05
JP5452608B2 (ja) 2014-03-26
AR074409A1 (es) 2011-01-12
RU2011123703A (ru) 2013-01-10
US20100137286A1 (en) 2010-06-03
ES2431279T3 (es) 2013-11-25
CN102227428A (zh) 2011-10-26
HK1160642A1 (en) 2012-08-10
UA103504C2 (ru) 2013-10-25
TWI379833B (en) 2012-12-21
CA2743976C (en) 2017-02-21
BRPI0922303B1 (pt) 2019-11-12
WO2010060836A1 (en) 2010-06-03
MY150837A (en) 2014-02-28
US8227458B2 (en) 2012-07-24
US20120225865A1 (en) 2012-09-06
NZ592076A (en) 2012-06-29
CR20110220A (es) 2011-06-21
HRP20131067T1 (hr) 2013-12-06
CN102227428B (zh) 2015-03-25
JP2012510441A (ja) 2012-05-10
EP2370441B1 (en) 2013-09-11
DK2370441T3 (da) 2013-10-21
MA32781B1 (fr) 2011-11-01
SI2370441T1 (sl) 2013-12-31
TW201024300A (en) 2010-07-01
IL212122A0 (en) 2011-06-30
PL2370441T3 (pl) 2014-02-28
MX2011005596A (es) 2011-06-16
ZA201103419B (en) 2014-07-30
BRPI0922303A2 (pt) 2016-01-12
IL212122A (en) 2013-06-27
ECSP11011089A (es) 2011-06-30
AU2009319123B2 (en) 2014-10-23
PT2370441E (pt) 2013-11-14
SG171846A1 (en) 2011-07-28
PE20110582A1 (es) 2011-08-17
US8461152B2 (en) 2013-06-11

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