MX2014003600A - Ciclohexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenos como antagonistas v1a. - Google Patents
Ciclohexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenos como antagonistas v1a.Info
- Publication number
- MX2014003600A MX2014003600A MX2014003600A MX2014003600A MX2014003600A MX 2014003600 A MX2014003600 A MX 2014003600A MX 2014003600 A MX2014003600 A MX 2014003600A MX 2014003600 A MX2014003600 A MX 2014003600A MX 2014003600 A MX2014003600 A MX 2014003600A
- Authority
- MX
- Mexico
- Prior art keywords
- azulenes
- triaza
- oxa
- benzo
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
La presente invención proporciona 4H,6H-5-oxa-2,3,10b-triaza-benzo [e]azuleno, que actúa como modulador del receptor de V1a y en particular como antagonista del receptor V1a, su fabricación, composiciones farmacéuticas que contienen el mismo y su uso como medicamento. Los compuestos activos de la presente invención son útiles como agentes terapéuticos de acción periférica y centralmente en las condiciones de dismenorrea, disfunción sexual masculina o femenina, hipertensión, insuficiencia cardíaca crónica, secreción inapropiada de vasopresina, cirrosis hepática, síndrome nefrótico, ansiedad, trastornos depresivos, trastorno obsesivo compulsivo, trastornos del espectro autista, esquizofrenia y conducta agresiva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11183982 | 2011-10-05 | ||
PCT/EP2012/069392 WO2013050334A1 (en) | 2011-10-05 | 2012-10-02 | Cyclohexyl-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenes as v1a antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014003600A true MX2014003600A (es) | 2014-04-25 |
Family
ID=46963738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014003600A MX2014003600A (es) | 2011-10-05 | 2012-10-02 | Ciclohexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenos como antagonistas v1a. |
Country Status (10)
Country | Link |
---|---|
US (1) | US9346824B2 (es) |
EP (1) | EP2763997B1 (es) |
JP (1) | JP6062948B2 (es) |
KR (1) | KR20140082765A (es) |
CN (1) | CN103842365B (es) |
BR (1) | BR112014007851A2 (es) |
CA (1) | CA2847095A1 (es) |
MX (1) | MX2014003600A (es) |
RU (1) | RU2014117471A (es) |
WO (1) | WO2013050334A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3256476T3 (pl) * | 2015-02-11 | 2019-05-31 | Pgi Drug Discovery Llc | Związki i analogi fuzyjnego dihydro-4h-pirazolo[5,1-c][1,4]oksazynylu w leczeniu zaburzeń oun |
BR112017020824A2 (pt) | 2015-04-21 | 2018-07-03 | Jiangsu Hengrui Medicine Co., Ltd. | derivado de imidazo-isoindol, método de preparação do mesmo e uso médico do mesmo |
EP3490607A4 (en) | 2016-07-29 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | COMPOUNDS AND COMPOSITIONS, AND USES THEREOF |
BR112020001433A2 (pt) | 2017-08-02 | 2020-07-28 | Sunovion Pharmaceuticals Inc. | compostos de isocromano e usos dos mesmos |
CN110172068A (zh) * | 2019-06-05 | 2019-08-27 | 河南龙湖生物技术有限公司 | 具有抗肿瘤活性的苯并噻唑类化合物及其制备方法和应用 |
WO2022018105A1 (en) * | 2020-07-23 | 2022-01-27 | F. Hoffmann-La Roche Ag | Heteroaryl-methyl substituted triazoles as vasopressin receptor v1 a antagonists |
EP4185570A1 (en) * | 2020-07-23 | 2023-05-31 | F. Hoffmann-La Roche AG | Cyclohexyl substituted triazoles as vasopressin receptor v1 a antagonists |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4374842A (en) * | 1980-04-18 | 1983-02-22 | Shionogi & Co., Ltd. | 4,1-Benzoxazepines and compositions |
GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
GB0400700D0 (en) * | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
DE102004001871A1 (de) * | 2004-01-14 | 2005-09-01 | Bayer Healthcare Ag | Tricyclische Benzazepin-Derivate und ihre Verwendung |
GB0412874D0 (en) * | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Novel pharmaceuticals |
WO2010057795A1 (en) * | 2008-11-18 | 2010-05-27 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
ES2431279T3 (es) * | 2008-11-28 | 2013-11-25 | F. Hoffmann-La Roche Ag | Arilciclohexiléteres de dihidro-tetraazabenzoazulenos para uso como antagonistas del receptor V1A de la vasopresina |
-
2012
- 2012-10-02 WO PCT/EP2012/069392 patent/WO2013050334A1/en active Application Filing
- 2012-10-02 BR BR112014007851A patent/BR112014007851A2/pt not_active IP Right Cessation
- 2012-10-02 RU RU2014117471/04A patent/RU2014117471A/ru not_active Application Discontinuation
- 2012-10-02 CN CN201280048872.4A patent/CN103842365B/zh active Active
- 2012-10-02 EP EP12766670.9A patent/EP2763997B1/en active Active
- 2012-10-02 MX MX2014003600A patent/MX2014003600A/es unknown
- 2012-10-02 CA CA2847095A patent/CA2847095A1/en not_active Abandoned
- 2012-10-02 KR KR1020147011582A patent/KR20140082765A/ko not_active Application Discontinuation
- 2012-10-02 JP JP2014533847A patent/JP6062948B2/ja active Active
-
2014
- 2014-04-04 US US14/245,126 patent/US9346824B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20140221350A1 (en) | 2014-08-07 |
RU2014117471A (ru) | 2015-11-10 |
JP2014531462A (ja) | 2014-11-27 |
BR112014007851A2 (pt) | 2017-04-18 |
CA2847095A1 (en) | 2013-04-11 |
EP2763997B1 (en) | 2017-08-02 |
JP6062948B2 (ja) | 2017-01-18 |
EP2763997A1 (en) | 2014-08-13 |
WO2013050334A1 (en) | 2013-04-11 |
CN103842365B (zh) | 2017-06-23 |
CN103842365A (zh) | 2014-06-04 |
US9346824B2 (en) | 2016-05-24 |
KR20140082765A (ko) | 2014-07-02 |
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