MX2014003643A - Oxi-ciclohexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e] azulenos como antagonistas de v1a. - Google Patents
Oxi-ciclohexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e] azulenos como antagonistas de v1a.Info
- Publication number
- MX2014003643A MX2014003643A MX2014003643A MX2014003643A MX2014003643A MX 2014003643 A MX2014003643 A MX 2014003643A MX 2014003643 A MX2014003643 A MX 2014003643A MX 2014003643 A MX2014003643 A MX 2014003643A MX 2014003643 A MX2014003643 A MX 2014003643A
- Authority
- MX
- Mexico
- Prior art keywords
- azulenes
- triaza
- oxa
- benzo
- antagonists
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención proporciona 4H,6H-5-oxa-2,3,10b-triaza-benzo [e]azulenos, que actúan como moduladores del receptor de la V1a y en particular como antagonistas del receptor de la V1a, su obtención, composiciones farmacéuticas que los contienen y su utilización como medicamentos. Los compuestos activos de la presente invención son útiles como agentes terapéuticos que actúan a nivel periférico y central en estados patológicos tales como la dismenorrea, disfunción sexual masculina y femenina, hipertensión, fallo cardíaco crónico, secreción inapropiada de vasopresina, cirrosis hepática, síndrome nefrótico, ansiedad, trastornos depresivos, trastorno obsesivo-compulsivo, trastornos del espectro autista, esquizofrenia y conducta agresiva.(ver fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11182796 | 2011-09-26 | ||
| PCT/EP2012/068721 WO2013045373A1 (en) | 2011-09-26 | 2012-09-24 | Oxy-cyclohexyl-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenes as v1a antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2014003643A true MX2014003643A (es) | 2014-04-30 |
Family
ID=46881068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014003643A MX2014003643A (es) | 2011-09-26 | 2012-09-24 | Oxi-ciclohexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e] azulenos como antagonistas de v1a. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8828989B2 (es) |
| EP (1) | EP2760871B1 (es) |
| JP (1) | JP5909554B2 (es) |
| KR (1) | KR101682777B1 (es) |
| CN (1) | CN103827121B (es) |
| AR (1) | AR087999A1 (es) |
| AU (1) | AU2012314593B2 (es) |
| BR (1) | BR112014006945A2 (es) |
| CA (1) | CA2844581A1 (es) |
| CL (1) | CL2014000717A1 (es) |
| CO (1) | CO6870036A2 (es) |
| CR (1) | CR20140092A (es) |
| EA (1) | EA024990B1 (es) |
| EC (1) | ECSP14013271A (es) |
| IN (1) | IN2014CN02169A (es) |
| MA (1) | MA35535B1 (es) |
| MX (1) | MX2014003643A (es) |
| PE (1) | PE20141397A1 (es) |
| SG (1) | SG2014010607A (es) |
| TW (1) | TWI553013B (es) |
| UA (1) | UA111623C2 (es) |
| WO (1) | WO2013045373A1 (es) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69911259T4 (de) | 1999-01-19 | 2009-07-09 | Ortho-Mcneil Pharmaceutical, Inc. | Tricyclische benzodiazepine als vasopressin antagonisten |
| US6765004B1 (en) | 1999-06-17 | 2004-07-20 | Ortho-Mcneil Pharmaceutical, Inc. | Indoloazepines as vasopressin receptor antagonists |
| GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| US7119088B2 (en) | 2003-02-19 | 2006-10-10 | Pfizer Inc. | Triazole compounds useful in therapy |
| GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| MX2007002248A (es) * | 2004-08-25 | 2008-10-02 | Pfizer | Triazolobenzodiazepinas y su uso como antagonistas de vasopresina. |
| ES2391374T3 (es) | 2008-11-18 | 2012-11-23 | F. Hoffmann-La Roche Ag | Alquilciclohexiléteres de dihidrotetraazabenzoazulenos |
| ES2431279T3 (es) | 2008-11-28 | 2013-11-25 | F. Hoffmann-La Roche Ag | Arilciclohexiléteres de dihidro-tetraazabenzoazulenos para uso como antagonistas del receptor V1A de la vasopresina |
-
2012
- 2012-08-23 US US13/592,493 patent/US8828989B2/en active Active
- 2012-09-24 CN CN201280046689.0A patent/CN103827121B/zh active Active
- 2012-09-24 AU AU2012314593A patent/AU2012314593B2/en not_active Ceased
- 2012-09-24 BR BR112014006945A patent/BR112014006945A2/pt not_active IP Right Cessation
- 2012-09-24 KR KR1020147010783A patent/KR101682777B1/ko active IP Right Grant
- 2012-09-24 SG SG2014010607A patent/SG2014010607A/en unknown
- 2012-09-24 EP EP12761740.5A patent/EP2760871B1/en active Active
- 2012-09-24 UA UAA201403611A patent/UA111623C2/uk unknown
- 2012-09-24 MX MX2014003643A patent/MX2014003643A/es unknown
- 2012-09-24 IN IN2169CHN2014 patent/IN2014CN02169A/en unknown
- 2012-09-24 PE PE2014000394A patent/PE20141397A1/es not_active Application Discontinuation
- 2012-09-24 CA CA2844581A patent/CA2844581A1/en not_active Abandoned
- 2012-09-24 WO PCT/EP2012/068721 patent/WO2013045373A1/en active Application Filing
- 2012-09-24 JP JP2014532331A patent/JP5909554B2/ja active Active
- 2012-09-24 EA EA201490558A patent/EA024990B1/ru not_active IP Right Cessation
- 2012-09-25 TW TW101135168A patent/TWI553013B/zh not_active IP Right Cessation
- 2012-09-25 AR ARP120103514A patent/AR087999A1/es unknown
-
2014
- 2014-01-31 CO CO14020668A patent/CO6870036A2/es not_active Application Discontinuation
- 2014-02-26 CR CR20140092A patent/CR20140092A/es unknown
- 2014-03-24 CL CL2014000717A patent/CL2014000717A1/es unknown
- 2014-03-26 EC ECSP14013271 patent/ECSP14013271A/es unknown
- 2014-04-15 MA MA36919A patent/MA35535B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2844581A1 (en) | 2013-04-04 |
| EA201490558A1 (ru) | 2014-06-30 |
| AU2012314593A8 (en) | 2014-03-27 |
| UA111623C2 (uk) | 2016-05-25 |
| WO2013045373A1 (en) | 2013-04-04 |
| EP2760871A1 (en) | 2014-08-06 |
| ECSP14013271A (es) | 2014-05-31 |
| JP2014527993A (ja) | 2014-10-23 |
| US20130079333A1 (en) | 2013-03-28 |
| NZ620653A (en) | 2016-03-31 |
| AU2012314593A1 (en) | 2014-02-20 |
| EA024990B1 (ru) | 2016-11-30 |
| AR087999A1 (es) | 2014-04-30 |
| CL2014000717A1 (es) | 2014-10-03 |
| CO6870036A2 (es) | 2014-02-20 |
| PE20141397A1 (es) | 2014-10-13 |
| KR101682777B1 (ko) | 2016-12-05 |
| EP2760871B1 (en) | 2018-07-18 |
| BR112014006945A2 (pt) | 2017-04-04 |
| CN103827121A (zh) | 2014-05-28 |
| IN2014CN02169A (es) | 2015-05-29 |
| CR20140092A (es) | 2014-03-20 |
| CN103827121B (zh) | 2016-08-03 |
| SG2014010607A (en) | 2014-05-29 |
| US8828989B2 (en) | 2014-09-09 |
| KR20140079790A (ko) | 2014-06-27 |
| TWI553013B (zh) | 2016-10-11 |
| AU2012314593B2 (en) | 2016-09-29 |
| TW201315737A (zh) | 2013-04-16 |
| MA35535B1 (fr) | 2014-10-02 |
| JP5909554B2 (ja) | 2016-04-26 |
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