BR112014006945A2 - óxi-ciclo-hexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenos como antagonistas de v1a - Google Patents

óxi-ciclo-hexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenos como antagonistas de v1a

Info

Publication number
BR112014006945A2
BR112014006945A2 BR112014006945A BR112014006945A BR112014006945A2 BR 112014006945 A2 BR112014006945 A2 BR 112014006945A2 BR 112014006945 A BR112014006945 A BR 112014006945A BR 112014006945 A BR112014006945 A BR 112014006945A BR 112014006945 A2 BR112014006945 A2 BR 112014006945A2
Authority
BR
Brazil
Prior art keywords
azulenes
triaza
oxa
benzo
antagonists
Prior art date
Application number
BR112014006945A
Other languages
English (en)
Inventor
Dolente Cosimo
Schnider Patrick
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014006945A2 publication Critical patent/BR112014006945A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

resumo patente de invenção: "óxi-ciclo-hexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenos como antagonistas de v1a". i a presente invenção refere-se a 4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenos, que agem como moduladores de receptor de v1a, e em particular como antagonistas de receptor de v1a, sua fabricação, composições farmacêuticas contendo-os e seu uso como medicamentos. os compostos ativos da presente invenção são úteis como produtos terapêuticos que agem periférica e centralmente, nas condições de dismenorreia, disfunção sexual masculina ou feminina, hipertensão, insuficiência cardíaca crônica, secreção inapropriada de vasopressina, cirrose hepática, síndrome nefrótica, ansiedade, distúrbios depressivos, distúrbio obsessivo-compulsivo, distúrbios de espectro autístico, esquizofrenia e comportamento agressivo.
BR112014006945A 2011-09-26 2012-09-24 óxi-ciclo-hexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenos como antagonistas de v1a BR112014006945A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11182796 2011-09-26
PCT/EP2012/068721 WO2013045373A1 (en) 2011-09-26 2012-09-24 Oxy-cyclohexyl-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenes as v1a antagonists

Publications (1)

Publication Number Publication Date
BR112014006945A2 true BR112014006945A2 (pt) 2017-04-04

Family

ID=46881068

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014006945A BR112014006945A2 (pt) 2011-09-26 2012-09-24 óxi-ciclo-hexil-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenos como antagonistas de v1a

Country Status (22)

Country Link
US (1) US8828989B2 (pt)
EP (1) EP2760871B1 (pt)
JP (1) JP5909554B2 (pt)
KR (1) KR101682777B1 (pt)
CN (1) CN103827121B (pt)
AR (1) AR087999A1 (pt)
AU (1) AU2012314593B2 (pt)
BR (1) BR112014006945A2 (pt)
CA (1) CA2844581A1 (pt)
CL (1) CL2014000717A1 (pt)
CO (1) CO6870036A2 (pt)
CR (1) CR20140092A (pt)
EA (1) EA024990B1 (pt)
EC (1) ECSP14013271A (pt)
IN (1) IN2014CN02169A (pt)
MA (1) MA35535B1 (pt)
MX (1) MX2014003643A (pt)
PE (1) PE20141397A1 (pt)
SG (1) SG2014010607A (pt)
TW (1) TWI553013B (pt)
UA (1) UA111623C2 (pt)
WO (1) WO2013045373A1 (pt)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1147115B3 (en) 1999-01-19 2008-12-24 Ortho-McNeil Pharmaceutical, Inc. Tricyclic benzodiazepines as vasopressin receptor antagonists
US6765004B1 (en) 1999-06-17 2004-07-20 Ortho-Mcneil Pharmaceutical, Inc. Indoloazepines as vasopressin receptor antagonists
GB0303852D0 (en) * 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
US7119088B2 (en) 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
GB0400700D0 (en) 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
JP2008510789A (ja) * 2004-08-25 2008-04-10 ファイザー・インク トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用
WO2010057795A1 (en) 2008-11-18 2010-05-27 F. Hoffmann-La Roche Ag Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
ES2431279T3 (es) 2008-11-28 2013-11-25 F. Hoffmann-La Roche Ag Arilciclohexiléteres de dihidro-tetraazabenzoazulenos para uso como antagonistas del receptor V1A de la vasopresina

Also Published As

Publication number Publication date
AU2012314593A8 (en) 2014-03-27
TW201315737A (zh) 2013-04-16
UA111623C2 (uk) 2016-05-25
SG2014010607A (en) 2014-05-29
JP5909554B2 (ja) 2016-04-26
EA201490558A1 (ru) 2014-06-30
MX2014003643A (es) 2014-04-30
PE20141397A1 (es) 2014-10-13
CO6870036A2 (es) 2014-02-20
CN103827121A (zh) 2014-05-28
MA35535B1 (fr) 2014-10-02
EA024990B1 (ru) 2016-11-30
KR101682777B1 (ko) 2016-12-05
KR20140079790A (ko) 2014-06-27
CN103827121B (zh) 2016-08-03
AU2012314593A1 (en) 2014-02-20
JP2014527993A (ja) 2014-10-23
US20130079333A1 (en) 2013-03-28
EP2760871B1 (en) 2018-07-18
NZ620653A (en) 2016-03-31
EP2760871A1 (en) 2014-08-06
TWI553013B (zh) 2016-10-11
US8828989B2 (en) 2014-09-09
CA2844581A1 (en) 2013-04-04
IN2014CN02169A (pt) 2015-05-29
AU2012314593B2 (en) 2016-09-29
WO2013045373A1 (en) 2013-04-04
CR20140092A (es) 2014-03-20
AR087999A1 (es) 2014-04-30
CL2014000717A1 (es) 2014-10-03
ECSP14013271A (es) 2014-05-31

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2480 DE 17-07-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.