BR112013023984A2 - derivados triazolil piperazina e triazolil piperidina substituidos como moduladores de gama secretase - Google Patents

derivados triazolil piperazina e triazolil piperidina substituidos como moduladores de gama secretase

Info

Publication number
BR112013023984A2
BR112013023984A2 BR112013023984A BR112013023984A BR112013023984A2 BR 112013023984 A2 BR112013023984 A2 BR 112013023984A2 BR 112013023984 A BR112013023984 A BR 112013023984A BR 112013023984 A BR112013023984 A BR 112013023984A BR 112013023984 A2 BR112013023984 A2 BR 112013023984A2
Authority
BR
Brazil
Prior art keywords
triazolyl
piperazine
piperidine derivatives
gamma secretase
secretase modulators
Prior art date
Application number
BR112013023984A
Other languages
English (en)
Inventor
Adriana Ingrid Velter
Didier Jean-Claude Berthelot
François Paul Bischoff
Sven Franciscus Anna Van Brandt
Original Assignee
Cellzome Ltd
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ltd, Janssen Pharmaceuticals Inc filed Critical Cellzome Ltd
Publication of BR112013023984A2 publication Critical patent/BR112013023984A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

derivados triazolil piperazina e triazolil piperidina substituidos como moduladores de gama secretase a presente invenção refere-se a derivados triazolil piperazina e triazolil piperidina substituídos da fórmula (i) em que r^ 1^, r^ 2^, r^ 3^, r^ 4a^, r^ 4b^, r^ 5^, x, y^ 1^, y^ 2^, l^ 1^ e l^ 2^ têm o significado definido nas reinvidicações. os compostos de acordo com a presente invenção são úteis como moduladores de gama secretase. a invenção também refere-se a processos para a preparação desses compostos, a composições farmacêuticas compreendendo os referidos compostos como ingrediente ativo, bem como à utilização dos referidos compostos como medicamento.
BR112013023984A 2011-03-24 2012-03-22 derivados triazolil piperazina e triazolil piperidina substituidos como moduladores de gama secretase BR112013023984A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11159639 2011-03-24
PCT/EP2012/055079 WO2012126984A1 (en) 2011-03-24 2012-03-22 Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators

Publications (1)

Publication Number Publication Date
BR112013023984A2 true BR112013023984A2 (pt) 2016-09-13

Family

ID=43952127

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013023984A BR112013023984A2 (pt) 2011-03-24 2012-03-22 derivados triazolil piperazina e triazolil piperidina substituidos como moduladores de gama secretase

Country Status (12)

Country Link
US (1) US8987276B2 (pt)
EP (1) EP2688874B1 (pt)
JP (1) JP2014508794A (pt)
KR (1) KR20140047032A (pt)
CN (1) CN103502225B (pt)
AR (1) AR085549A1 (pt)
AU (1) AU2012230348A1 (pt)
BR (1) BR112013023984A2 (pt)
CA (1) CA2827969A1 (pt)
ES (1) ES2536442T3 (pt)
MX (1) MX2013010970A (pt)
WO (1) WO2012126984A1 (pt)

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Also Published As

Publication number Publication date
US20140011816A1 (en) 2014-01-09
CN103502225B (zh) 2015-11-25
EP2688874B1 (en) 2015-03-04
CN103502225A (zh) 2014-01-08
JP2014508794A (ja) 2014-04-10
EP2688874A1 (en) 2014-01-29
KR20140047032A (ko) 2014-04-21
AU2012230348A1 (en) 2013-08-29
US8987276B2 (en) 2015-03-24
WO2012126984A1 (en) 2012-09-27
AU2012230348A8 (en) 2013-09-05
MX2013010970A (es) 2013-10-17
AR085549A1 (es) 2013-10-09
ES2536442T3 (es) 2015-05-25
CA2827969A1 (en) 2012-09-27

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B25B Requested transfer of rights rejected

Owner name: JANSSEN PHARMACEUTICALS, INC. (US) , CELLZOME LIMI