BR112014000713A2 - derivados de indol substituído como moduladores de gama secretase - Google Patents
derivados de indol substituído como moduladores de gama secretaseInfo
- Publication number
- BR112014000713A2 BR112014000713A2 BR112014000713A BR112014000713A BR112014000713A2 BR 112014000713 A2 BR112014000713 A2 BR 112014000713A2 BR 112014000713 A BR112014000713 A BR 112014000713A BR 112014000713 A BR112014000713 A BR 112014000713A BR 112014000713 A2 BR112014000713 A2 BR 112014000713A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- indole derivatives
- gamma secretase
- substituted indole
- secretase modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
abstract novel substituted indole derivatives as gamma secretase modulators ____________________________________________ the present invention is concerned with novel substituted indole derivatives of formula (i) wherein r1, r2, r3, a1, a2, a3, y and x have the meaning defined in the claims. the compounds according to the present invention are useful as gamma secretase modulators. the invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. 129 ******************************************************* tradução do resumo resumo patente de invenção: "derivados de indol substituído como moduladores de gama secretase". a presente invenção refere-se a novos derivados de indol substituído de fórmula (i) em que r1, r2, r3, a1, a2, a3, y e x têm o significado definido nas reivindicações. os compostos de acordo com a presente invenção são úteis como moduladores de gama secretase. a invenção também se refere a processos para a preparação desses compostos novos, a composições farmacêuticas compreendendo os referidos compostos como ingrediente ativo, bem como à utilização dos referidos compostos como medicamento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11174120 | 2011-07-15 | ||
PCT/EP2012/063667 WO2013010904A1 (en) | 2011-07-15 | 2012-07-12 | Novel substituted indole derivatives as gamma secretase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014000713A2 true BR112014000713A2 (pt) | 2017-01-10 |
Family
ID=46506432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014000713A BR112014000713A2 (pt) | 2011-07-15 | 2012-07-12 | derivados de indol substituído como moduladores de gama secretase |
Country Status (16)
Country | Link |
---|---|
US (1) | US9115143B2 (pt) |
EP (1) | EP2731948B1 (pt) |
JP (1) | JP6068464B2 (pt) |
KR (1) | KR101913135B1 (pt) |
CN (1) | CN103874702B (pt) |
AR (1) | AR087182A1 (pt) |
AU (1) | AU2012285931B2 (pt) |
BR (1) | BR112014000713A2 (pt) |
CA (1) | CA2841102C (pt) |
EA (1) | EA023045B1 (pt) |
ES (1) | ES2555167T3 (pt) |
IL (1) | IL230422B (pt) |
IN (1) | IN2014MN00258A (pt) |
MX (1) | MX2014000626A (pt) |
TW (1) | TWI567079B (pt) |
WO (1) | WO2013010904A1 (pt) |
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CN102325765B (zh) | 2009-02-06 | 2014-12-24 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的双环杂环化合物 |
CN102439005B (zh) | 2009-05-07 | 2015-07-22 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的吲唑和氮杂-吲唑衍生物 |
KR20120050450A (ko) | 2009-07-15 | 2012-05-18 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체 |
US9145399B2 (en) | 2010-01-15 | 2015-09-29 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic triazole derivatives as gamma secretase modulators |
AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
IN2014MN00258A (pt) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc | |
JP6106745B2 (ja) | 2012-05-16 | 2017-04-05 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | (特に)アルツハイマー病の治療に有用な置換3,4−ジヒドロ−2H−ピリド[1,2−a]ピラジン−1,6−ジオン誘導体 |
EP2738172A1 (en) * | 2012-11-28 | 2014-06-04 | Almirall, S.A. | New bicyclic compounds as crac channel modulators |
US10112943B2 (en) | 2012-12-20 | 2018-10-30 | Janssen Pharmaceutica Nv | Substituted imidazoles as gamma secretase modulators |
AU2014206834B2 (en) | 2013-01-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
US11180474B2 (en) | 2016-07-30 | 2021-11-23 | Bristol-Myers Squibb Company | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors |
ES2902504T3 (es) | 2016-09-09 | 2022-03-28 | Bristol Myers Squibb Co | Compuestos de indol sustituidos con piridilo |
JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
WO2019028301A1 (en) | 2017-08-04 | 2019-02-07 | Bristol-Myers Squibb Company | INDOLE COMPOUNDS SUBSTITUTED WITH [1,2,4] TRIAZOLO [4,3-A] PYRIDINYL |
US11447466B2 (en) | 2017-08-04 | 2022-09-20 | Bristol-Myers Squibb Company | Substituted indole compounds useful as inhibitors of TLR7/8/9 |
KR20200070297A (ko) * | 2017-10-11 | 2020-06-17 | 에프. 호프만-라 로슈 아게 | Rip1 키나아제 억제제로서 사용하기 위한 이환형 화합물 |
EP3710440B1 (en) * | 2017-11-14 | 2023-04-05 | Bristol-Myers Squibb Company | Substituted indole compounds |
CA3085817A1 (en) | 2017-12-18 | 2019-06-27 | Bristol-Myers Squibb Company | 4-azaindole compounds |
WO2019126113A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Substituted indole compounds useful as tlr inhibitors |
EA202091483A1 (ru) | 2017-12-19 | 2020-10-28 | Бристол-Маерс Сквибб Компани | Амидзамещенные индольные соединения, пригодные в качестве ингибиторов tlr |
EP3728253B1 (en) | 2017-12-19 | 2024-03-27 | Bristol-Myers Squibb Company | 6-azaindole compounds |
EA202091479A1 (ru) | 2017-12-20 | 2020-11-24 | Бристол-Маерс Сквибб Компани | Арил- и гетероарилзамещенные индольные соединения |
CN111491929B (zh) | 2017-12-20 | 2023-11-28 | 百时美施贵宝公司 | 可用作tlr抑制剂的氨基吲哚化合物 |
SG11202005733QA (en) | 2017-12-20 | 2020-07-29 | Bristol Myers Squibb Co | Diazaindole compounds |
KR20210054515A (ko) * | 2018-09-03 | 2021-05-13 | 에프. 호프만-라 로슈 아게 | 바이사이클릭 헤테로아릴 유도체 |
EP3628669A1 (en) * | 2018-09-28 | 2020-04-01 | GenKyoTex Suisse SA | Novel compounds as nadph oxidase inhibitors |
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-
2012
- 2012-07-12 IN IN258MUN2014 patent/IN2014MN00258A/en unknown
- 2012-07-12 KR KR1020147003465A patent/KR101913135B1/ko active IP Right Grant
- 2012-07-12 EA EA201490287A patent/EA023045B1/ru not_active IP Right Cessation
- 2012-07-12 JP JP2014519557A patent/JP6068464B2/ja not_active Expired - Fee Related
- 2012-07-12 BR BR112014000713A patent/BR112014000713A2/pt active Search and Examination
- 2012-07-12 CN CN201280034912.XA patent/CN103874702B/zh not_active Expired - Fee Related
- 2012-07-12 ES ES12733754.1T patent/ES2555167T3/es active Active
- 2012-07-12 MX MX2014000626A patent/MX2014000626A/es unknown
- 2012-07-12 TW TW101125035A patent/TWI567079B/zh not_active IP Right Cessation
- 2012-07-12 US US14/233,078 patent/US9115143B2/en not_active Expired - Fee Related
- 2012-07-12 AU AU2012285931A patent/AU2012285931B2/en not_active Ceased
- 2012-07-12 WO PCT/EP2012/063667 patent/WO2013010904A1/en active Application Filing
- 2012-07-12 EP EP12733754.1A patent/EP2731948B1/en active Active
- 2012-07-12 CA CA2841102A patent/CA2841102C/en not_active Expired - Fee Related
- 2012-07-13 AR ARP120102548A patent/AR087182A1/es not_active Application Discontinuation
-
2014
- 2014-01-13 IL IL230422A patent/IL230422B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
IN2014MN00258A (pt) | 2015-09-25 |
EP2731948B1 (en) | 2015-09-09 |
IL230422B (en) | 2018-03-29 |
JP2014518286A (ja) | 2014-07-28 |
KR101913135B1 (ko) | 2018-10-30 |
ES2555167T3 (es) | 2015-12-29 |
CA2841102C (en) | 2019-08-13 |
AU2012285931B2 (en) | 2017-01-12 |
CN103874702A (zh) | 2014-06-18 |
EP2731948A1 (en) | 2014-05-21 |
NZ619683A (en) | 2015-01-30 |
KR20140063595A (ko) | 2014-05-27 |
MX2014000626A (es) | 2014-04-30 |
EA023045B1 (ru) | 2016-04-29 |
JP6068464B2 (ja) | 2017-01-25 |
WO2013010904A1 (en) | 2013-01-24 |
CA2841102A1 (en) | 2013-01-24 |
EA201490287A1 (ru) | 2014-05-30 |
US20140148450A1 (en) | 2014-05-29 |
TWI567079B (zh) | 2017-01-21 |
CN103874702B (zh) | 2015-12-09 |
US9115143B2 (en) | 2015-08-25 |
TW201315736A (zh) | 2013-04-16 |
AR087182A1 (es) | 2014-02-26 |
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