AR086086A1 - Derivados glucosidos y usos de los mismos - Google Patents
Derivados glucosidos y usos de los mismosInfo
- Publication number
- AR086086A1 AR086086A1 ARP120101273A ARP120101273A AR086086A1 AR 086086 A1 AR086086 A1 AR 086086A1 AR P120101273 A ARP120101273 A AR P120101273A AR P120101273 A ARP120101273 A AR P120101273A AR 086086 A1 AR086086 A1 AR 086086A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- group
- membered heteroaryl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente además proporciona una combinación de agentes farmacológicamente activos y una composición farmacéutica.Reivindicación 1: Un compuesto representado por la fórmula estructural (1) o una sal farmacéuticamente aceptable del mismo, en donde: A se selecciona entre los restos del grupo de fórmulas (2); V es hidrógeno, halo u OR1b-; R1, R1a y R1b se seleccionan independientemente del grupo constituido por hidrógeno, alquilo C1-6, aril C6-10-alquilo C1-4, -C(O)-arilo C6-10 y -C(O)-alquilo C1-6; R2 y R2a, en cada caso, se seleccionan independientemente entre el grupo formado por halo, hidroxilo, alquilo C1-6, y alcoxilo C1-6; R3 es halo, hidroxilo, alquilo C1-6, haloalquilo C1-6-, cicloalquilo C3-10-, alcoxilo C1-6, o halo-alcoxilo C1-3-; R4 se selecciona del grupo de fórmulas (3); R5 es una cadena lateral de aminoácidos; R6 es un alquilo C1-6, cicloalquilo C3-10, cicloalquil C3-10-alquilo C1-4, heterocicloalquilo de 3- a 10- miembros, (heterocicloalquilo de 3- a 10- miembros)-alquilo C1-4, arilo C6-10, arilo C6-10-alquilo C1-4, heteroarilo de 5- a 10- miembros, o (heteroarilo de 5- a 10- miembros)-alquilo C1-4; R7, para cada ocurrencia, es independientemente hidrógeno, alquilo C1-6, cicloalquilo C3-10, cicloalquil C3-10-alquilo C1-4, heterocicloalquilo de 3- a 10- miembros, (heterocicloalquilo de 3- a 10- miembros)-alquilo C1-4, arilo C6-10, aril C6-10-alquilo C1-4, heteroarilo de 5- a 10- miembros, o (heteroarilo de 5- a 10- miembros)-alquilo C1-4; n es 0, 1, 2, ó 3, y q es 0, 1 ó 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161475476P | 2011-04-14 | 2011-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086086A1 true AR086086A1 (es) | 2013-11-20 |
Family
ID=46028035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101273A AR086086A1 (es) | 2011-04-14 | 2012-04-13 | Derivados glucosidos y usos de los mismos |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8614195B2 (es) |
| EP (1) | EP2697217B1 (es) |
| JP (1) | JP5908973B2 (es) |
| KR (1) | KR20140027250A (es) |
| CN (1) | CN103748090B (es) |
| AP (1) | AP2013007179A0 (es) |
| AR (1) | AR086086A1 (es) |
| AU (1) | AU2012241427B2 (es) |
| BR (1) | BR112013026257A2 (es) |
| CA (1) | CA2832958A1 (es) |
| CL (1) | CL2013002973A1 (es) |
| CO (1) | CO6781541A2 (es) |
| CR (1) | CR20130530A (es) |
| CU (1) | CU20130139A7 (es) |
| EA (1) | EA201391525A1 (es) |
| ES (1) | ES2621007T3 (es) |
| IL (1) | IL228771A0 (es) |
| MA (1) | MA35032B1 (es) |
| MX (1) | MX2013011927A (es) |
| PE (1) | PE20141039A1 (es) |
| SG (1) | SG194463A1 (es) |
| TN (1) | TN2013000413A1 (es) |
| TW (1) | TW201245219A (es) |
| UY (1) | UY34018A (es) |
| WO (1) | WO2012140597A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5876570B2 (ja) * | 2011-06-01 | 2016-03-02 | グリーン・クロス・コーポレイションＧｒｅｅｎ Ｃｒｏｓｓ Ｃｏｒｐ． | Ｓｇｌｔ２阻害剤としての新規のジフェニルメタン誘導体 |
| DK2981269T3 (da) | 2013-04-04 | 2023-10-23 | Boehringer Ingelheim Vetmedica Gmbh | Behandling af stofskifteforstyrrelser hos hestedyr |
| US10011627B2 (en) | 2013-09-09 | 2018-07-03 | Youngene Therapeutics Co., Ltd | C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof |
| WO2015043511A1 (en) | 2013-09-27 | 2015-04-02 | Sunshine Lake Pharma Co., Ltd. | Glucopyranosyl derivatives and their uses in medicine |
| SI3862003T1 (sl) | 2013-12-17 | 2024-02-29 | Boehringer Ingelheim Vetmedica Gmbh | Inhibitor SGLT-2 za uporabo pri zdravljenju metabolične motnje pri mačjih živalih |
| EP3485890B1 (en) | 2014-01-23 | 2023-05-10 | Boehringer Ingelheim Vetmedica GmbH | Sglt2 inhibitors for treatment of metabolic disorders in canine animals |
| PT3125882T (pt) * | 2014-04-01 | 2020-08-17 | Boehringer Ingelheim Vetmedica Gmbh | Tratamento de distúrbios metabólicos em animais equinos |
| AU2015320975B2 (en) | 2014-09-25 | 2020-10-08 | Boehringer Ingelheim Vetmedica Gmbh | Combination treatment of SGLT2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals |
| EA201890592A1 (ru) | 2015-08-27 | 2018-09-28 | Бёрингер Ингельхайм Ветмедика Гмбх | Жидкие фармацевтические композиции, содержащие ингибиторы sglt-2 |
| CN105294624B (zh) * | 2015-11-16 | 2018-01-12 | 山东罗欣药业集团股份有限公司 | 一种达格列净的制备方法 |
| CN108203432B (zh) * | 2016-12-20 | 2021-03-02 | 宜昌东阳光长江药业股份有限公司 | 吡喃葡萄糖基衍生物及其在医药上的应用 |
| JP2020508961A (ja) * | 2017-03-03 | 2020-03-26 | ノバルティス アーゲー | Ｓｇｌｔ１／２阻害剤の投与レジメン |
| WO2020242253A1 (ko) * | 2019-05-30 | 2020-12-03 | 동아에스티 주식회사 | Sglt-2 억제제인 신규 엠파글리플로진 유도체 |
| CN113330017B (zh) * | 2019-12-19 | 2023-01-31 | 上海研健新药研发有限公司 | 一种SGLTs抑制剂的纯化方法及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1020944C (zh) | 1990-01-30 | 1993-05-26 | 阿图尔-费希尔股份公司费希尔厂 | 紧固件 |
| TR200201082T2 (tr) | 1999-08-31 | 2002-07-22 | Kissei Pharmaceutical Co., Ltd. | Glikopriranoziloksipirazol türevleri |
| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| US6627611B2 (en) * | 2000-02-02 | 2003-09-30 | Kotobuki Pharmaceutical Co Ltd | C-glycosides and preparation of thereof as antidiabetic agents |
| SK287183B6 (sk) | 2000-03-17 | 2010-02-08 | Kissei Pharmaceutical Co., Ltd. | Glukopyranozyloxybenzylbenzenový derivát, farmaceutická kompozícia s jeho obsahom, ich použitie a medziprodukt |
| US6683056B2 (en) | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| PT1329456E (pt) | 2000-09-29 | 2006-12-29 | Kissei Pharmaceutical | Derivados de glucopiranosiloxibenzilbenzeno e composições medicinais que os contêm. |
| US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| US20030087843A1 (en) | 2001-09-05 | 2003-05-08 | Washburn William N. | O-pyrazole glucoside SGLT2 inhibitors and method of use |
| TW200303742A (en) | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| DE10231370B4 (de) | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| JP2004137245A (ja) | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| PL1980560T3 (pl) * | 2003-03-14 | 2011-11-30 | Astellas Pharma Inc | Pochodne C-glikozydowe do leczenia cukrzycy |
| AU2003902263A0 (en) | 2003-05-12 | 2003-05-29 | Fujisawa Pharmaceutical Co., Ltd. | Monosaccharide compounds |
| WO2004103995A1 (en) | 2003-05-20 | 2004-12-02 | Novartis Ag | N-acyl nitrogen heterocycles as ligands of peroxisome proliferator-activated receptors |
| RS20060320A (en) | 2003-08-01 | 2008-08-07 | Janssen Pharmaceutica N.V., | Substituted indazole-o-glucosides |
| DE502004008951D1 (de) | 2003-08-26 | 2009-03-19 | Boehringer Ingelheim Pharma | Glucopyranosyloxy-pyrazole, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| JP5078350B2 (ja) | 2004-03-04 | 2012-11-21 | キッセイ薬品工業株式会社 | 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 |
| US8058245B2 (en) | 2004-03-04 | 2011-11-15 | Kissei Pharmaceutical Co., Ltd. | Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof |
| DE102004028241B4 (de) * | 2004-06-11 | 2007-09-13 | Sanofi-Aventis Deutschland Gmbh | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
| US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
| DE102004034690A1 (de) | 2004-07-17 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| WO2006010557A1 (de) | 2004-07-27 | 2006-02-02 | Boehringer Ingelheim International Gmbh | D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| WO2006018150A1 (de) | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| DE102004048388A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| EP1813611B1 (en) | 2004-11-18 | 2014-10-01 | Kissei Pharmaceutical Co., Ltd. | 1-substituted-3- beta-d-glycopyranosylated nitrogenous hetero- cyclic compounds and medicines containing the same |
| AR053329A1 (es) * | 2005-01-31 | 2007-05-02 | Tanabe Seiyaku Co | Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt) |
| US20080027014A1 (en) | 2006-07-28 | 2008-01-31 | Tanabe Seiyaku Co., Ltd. | Novel SGLT inhibitors |
| TW200817424A (en) | 2006-08-04 | 2008-04-16 | Daiichi Sankyo Co Ltd | Benzylphenyl glucopyranoside derivatives |
| CL2009000309A1 (es) * | 2008-02-13 | 2009-06-26 | Sanofi Aventis | Derivados fluoroglicosidos aromaticos, composicion farmaceutica que contenga estos compuestos, procedimiento para prepararla y su uso en el tratamiento de la diabetes tipo 1 y 2. |
| WO2010128152A1 (en) * | 2009-05-07 | 2010-11-11 | Novartis Ag | Fused heterocyclic c-glycosides for the treatment of diabetes |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
-
2012
- 2012-04-04 US US13/439,155 patent/US8614195B2/en active Active
- 2012-04-12 CN CN201280028536.3A patent/CN103748090B/zh not_active Expired - Fee Related
- 2012-04-12 AP AP2010307179A patent/AP2013007179A0/xx unknown
- 2012-04-12 EP EP12719083.3A patent/EP2697217B1/en active Active
- 2012-04-12 BR BR112013026257A patent/BR112013026257A2/pt not_active IP Right Cessation
- 2012-04-12 KR KR1020137029813A patent/KR20140027250A/ko not_active Application Discontinuation
- 2012-04-12 EA EA201391525A patent/EA201391525A1/ru unknown
- 2012-04-12 PE PE2013002300A patent/PE20141039A1/es not_active Application Discontinuation
- 2012-04-12 WO PCT/IB2012/051799 patent/WO2012140597A1/en active Application Filing
- 2012-04-12 SG SG2013075908A patent/SG194463A1/en unknown
- 2012-04-12 ES ES12719083.3T patent/ES2621007T3/es active Active
- 2012-04-12 MA MA36319A patent/MA35032B1/fr unknown
- 2012-04-12 AU AU2012241427A patent/AU2012241427B2/en not_active Ceased
- 2012-04-12 UY UY0001034018A patent/UY34018A/es not_active Application Discontinuation
- 2012-04-12 MX MX2013011927A patent/MX2013011927A/es not_active Application Discontinuation
- 2012-04-12 CA CA2832958A patent/CA2832958A1/en not_active Abandoned
- 2012-04-12 JP JP2014504432A patent/JP5908973B2/ja not_active Expired - Fee Related
- 2012-04-13 AR ARP120101273A patent/AR086086A1/es unknown
- 2012-04-13 TW TW101113290A patent/TW201245219A/zh unknown
- 2012-09-13 US US13/613,090 patent/US20130018005A1/en not_active Abandoned
-
2013
- 2013-10-07 IL IL228771A patent/IL228771A0/en unknown
- 2013-10-10 CO CO13241013A patent/CO6781541A2/es not_active Application Discontinuation
- 2013-10-11 TN TNP2013000413A patent/TN2013000413A1/fr unknown
- 2013-10-14 CL CL2013002973A patent/CL2013002973A1/es unknown
- 2013-10-14 CR CR20130530A patent/CR20130530A/es unknown
- 2013-10-14 CU CU2013000139A patent/CU20130139A7/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012140597A1 (en) | 2012-10-18 |
| US20130018005A1 (en) | 2013-01-17 |
| EP2697217B1 (en) | 2016-12-28 |
| JP5908973B2 (ja) | 2016-04-26 |
| BR112013026257A2 (pt) | 2019-09-24 |
| EA201391525A1 (ru) | 2014-02-28 |
| TW201245219A (en) | 2012-11-16 |
| US20120264700A1 (en) | 2012-10-18 |
| MA35032B1 (fr) | 2014-04-03 |
| AP2013007179A0 (en) | 2013-10-31 |
| CN103748090A (zh) | 2014-04-23 |
| ES2621007T3 (es) | 2017-06-30 |
| PE20141039A1 (es) | 2014-08-30 |
| UY34018A (es) | 2012-11-30 |
| CR20130530A (es) | 2014-02-04 |
| CA2832958A1 (en) | 2012-10-18 |
| AU2012241427B2 (en) | 2014-11-20 |
| EP2697217A1 (en) | 2014-02-19 |
| IL228771A0 (en) | 2013-12-31 |
| CN103748090B (zh) | 2016-09-14 |
| JP2014511874A (ja) | 2014-05-19 |
| US8614195B2 (en) | 2013-12-24 |
| KR20140027250A (ko) | 2014-03-06 |
| TN2013000413A1 (en) | 2015-03-30 |
| CL2013002973A1 (es) | 2014-03-07 |
| CO6781541A2 (es) | 2013-10-31 |
| MX2013011927A (es) | 2013-11-01 |
| CU20130139A7 (es) | 2014-01-29 |
| AU2012241427A1 (en) | 2013-10-31 |
| SG194463A1 (en) | 2013-12-30 |
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