AR072162A1 - Compuestos de ester boronato y composiciones farmaceuticas de los mismos - Google Patents
Compuestos de ester boronato y composiciones farmaceuticas de los mismosInfo
- Publication number
- AR072162A1 AR072162A1 ARP090102187A ARP090102187A AR072162A1 AR 072162 A1 AR072162 A1 AR 072162A1 AR P090102187 A ARP090102187 A AR P090102187A AR P090102187 A ARP090102187 A AR P090102187A AR 072162 A1 AR072162 A1 AR 072162A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- independently
- substituted
- con
- aliphatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La presente provee compuestos utiles como inhibidores de proteasoma. Adem s provee composiciones farmaceuticas que comprenden los compuestos y metodos para utilizar las composiciones en el tratamiento de varias enfermedades. Reivindicacion 1: Un compuesto de formula (1): o una sal aceptable para uso farmaceutico del mismo, donde: A es 0, 1, o 2; P es hidrogeno o un resto bloqueador del grupo amino; Ra es hidrogeno, alif tico C1-6, fluoroalif tico C1-6, -(CH2)m-CH2-Rb, -(CH2)m-CH2-NHC(=NR4)NH-Y, -(CH2)m-CH2-CON(R4)2, -(CH2)m-CH2-N(R4)CON(R4)2, -(CH2)m-CH(R6)N(R4)2, -(CH2)m-CH(R5a)-OR5b o -(CH2)m-CH(R5)-SR5; Ra1 es hidrogeno, alif tico C1-6, fluoroalif tico C1-6, -(CH2)m-CH2-Rb, -(CH2)m-CH2-NHC(=NR4)NH-Y, -(CH2)m-CH2-CON(R4)2, -(CH2)m-CH2-N(R4)CON(R4)2, -(CH2)m-CH(R6)N(R4)2, -(CH2)m-CH(R5a)-OR5b, o -(CH2)m-CH(R5)-SR5; cada R2a independientemente es hidrogeno, alif tico C1-6, fluoroalif tico C1-6, -(CH2)m-CH2-Rb, -(CH2)m-CH2-NHC(=NR4)NH-Y, -(CH2)m-CH2-CON(R4)2, -(CH2)m-CH2-N(R4)CON(R4)2, -(CH2)m-CH(R6)N(R4)2, -(CH2)m-CH(R5a)-OR5b, o -(CH2)m-CH(R5)-SR5; cada RB independientemente es un sistema anular mono o bic¡clico sustituido o no sustituido; cada R4 independientemente es hidrogeno o un grupo alif tico, arilo, heteroarilo, o heterociclilo sustituido o no sustituido; o dos R4 sobre el mismo tomo de nitrogeno, tomados juntos con el tomo de nitrogeno, forman un anillo heterociclilo de 4 a 8 miembros sustituido o no sustituido que tiene, adem s del tomo de nitrogeno, 0-2 hetero tomos del anillo independientemente seleccionados de N, O, y S; cada R5 independientemente es hidrogeno o un grupo alif tico, arilo, heteroarilo, o heterociclilo sustituido o no sustituido; cada R5 independientemente es hidrogeno o un grupo alif tico, arilo, heteroarilo, o heterociclilo sustituido o no sustituido; cada R5b independientemente es hidrogeno o un grupo alif tico, arilo, heteroarilo, o heterociclilo sustituido o no sustituido; cada R6 independientemente es un grupo alif tico, arilo, o heteroarilo sustituido o no sustituido; Y es hidrogeno, -CN, o -NO2; m es 0, 1, o 2; y Z1 y Z2 juntos forman un resto que deriva de un cido alfa-hidroxi carbox¡lico, donde el tomo unido a boro en cada caso es un tomo de ox¡geno; o Z1 y Z2 juntos forman un resto que deriva de un cido beta-hidroxi carbox¡lico, donde el tomo unido a boro en cada caso es un tomo de ox¡geno.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13224408P | 2008-06-17 | 2008-06-17 | |
US21149909P | 2009-03-31 | 2009-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR072162A1 true AR072162A1 (es) | 2010-08-11 |
Family
ID=41061278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090102187A AR072162A1 (es) | 2008-06-17 | 2009-06-17 | Compuestos de ester boronato y composiciones farmaceuticas de los mismos |
Country Status (38)
Country | Link |
---|---|
US (17) | US20090325903A1 (es) |
EP (6) | EP2318419B1 (es) |
JP (9) | JP5566380B2 (es) |
KR (5) | KR101691093B1 (es) |
CN (10) | CN103467565A (es) |
AR (1) | AR072162A1 (es) |
AU (1) | AU2009260778B2 (es) |
BR (4) | BR122014008753A2 (es) |
CA (2) | CA2727862C (es) |
CL (1) | CL2010001475A1 (es) |
CO (1) | CO6321289A2 (es) |
CR (3) | CR11850A (es) |
CY (1) | CY1116435T1 (es) |
DK (2) | DK2730581T3 (es) |
DO (1) | DOP2010000384A (es) |
EA (4) | EA030685B1 (es) |
EC (2) | ECSP11010763A (es) |
ES (2) | ES2585114T3 (es) |
GE (2) | GEP20135847B (es) |
HK (9) | HK1198254A1 (es) |
HR (1) | HRP20150592T1 (es) |
IL (3) | IL210056B (es) |
MA (1) | MA32471B1 (es) |
MX (4) | MX349769B (es) |
MY (2) | MY155592A (es) |
NO (1) | NO2017016I1 (es) |
NZ (4) | NZ603236A (es) |
PE (5) | PE20141076A1 (es) |
PH (3) | PH12015501192A1 (es) |
PL (1) | PL2318419T3 (es) |
PT (2) | PT2318419E (es) |
RS (1) | RS54020B1 (es) |
SG (2) | SG10201701524XA (es) |
SI (1) | SI2318419T1 (es) |
TW (3) | TWI498333B (es) |
UA (1) | UA115131C2 (es) |
WO (1) | WO2009154737A1 (es) |
ZA (4) | ZA201009177B (es) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1948678E (pt) | 2005-11-09 | 2013-07-16 | Onyx Therapeutics Inc | Compostos para inibição de enzimas |
US7691852B2 (en) | 2006-06-19 | 2010-04-06 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
KR20170040374A (ko) | 2007-10-04 | 2017-04-12 | 오닉스 세라퓨틱스, 인크. | 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성 |
DK2730581T3 (en) * | 2008-06-17 | 2016-08-15 | Millennium Pharm Inc | Boronate Ester Compounds and Pharmaceutical Compositions thereof. |
KR101023994B1 (ko) | 2008-08-28 | 2011-03-28 | 한국생산기술연구원 | 디지털 밴드용 커넥터, 리셉터클 및 커넥터 조립체 |
AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
MX2011004225A (es) | 2008-10-21 | 2011-06-21 | Onyx Therapeutics Inc | Terapia de combinacion con epoxicetonas peptidicas. |
TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
WO2011060179A1 (en) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
MA34133B1 (fr) | 2010-03-01 | 2013-04-03 | Onyx Therapeutics Inc | Composes pour inhibiteurs de l'immunoproteasome |
CN102892291A (zh) | 2010-03-31 | 2013-01-23 | 米伦纽姆医药公司 | 1-氨基-2-环丙基乙硼酸衍生物 |
US8962572B2 (en) | 2010-10-05 | 2015-02-24 | Fresenius Kabi Usa, Llc | Bortezomib formulations |
CN102784114B (zh) * | 2011-05-14 | 2016-03-02 | 山东新时代药业有限公司 | 一种硼替佐米冻干粉针及其制备方法 |
EP2723751A1 (en) | 2011-06-22 | 2014-04-30 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013071142A1 (en) | 2011-11-11 | 2013-05-16 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
JP6286358B2 (ja) | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤に応答するバイオマーカー |
WO2013110005A1 (en) | 2012-01-18 | 2013-07-25 | Wisconsin Alumni Research Foundation | Boronate-mediated delivery of molecules into cells |
US9732101B2 (en) | 2012-01-18 | 2017-08-15 | Wisconsin Alumni Research Foundation | Bioreversible boronates for delivery of molecules into cells |
JP6215235B2 (ja) * | 2012-01-24 | 2017-10-18 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 癌の治療方法 |
CN104271583B (zh) | 2012-01-24 | 2017-10-24 | 米伦纽姆医药公司 | 治疗鼻咽癌的方法 |
EP2819673B1 (en) * | 2012-03-02 | 2016-09-07 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions comprising boronic acid compounds |
CA2784240C (en) | 2012-03-27 | 2014-07-08 | Innopharma, Inc. | Stable bortezomib formulations |
US9309283B2 (en) | 2012-07-09 | 2016-04-12 | Onyx Therapeutics, Inc. | Prodrugs of peptide epoxy ketone protease inhibitors |
ITMI20121394A1 (it) * | 2012-08-06 | 2014-02-07 | Chemi Spa | Esteri di bortezomib e loro formulazioni |
EP3008212A4 (en) * | 2013-06-10 | 2017-05-24 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
JP6165986B2 (ja) * | 2013-08-23 | 2017-07-19 | シントン・ビー.ブイ.Synthon B.V. | ボルテゾミブを含む医薬組成物 |
MX2016003979A (es) * | 2013-10-03 | 2016-06-15 | Millennium Pharm Inc | Metodo para profilaxis o tratamiento de lupus eritematoso sistemico y/o nefritis lupica. |
CN111116622A (zh) * | 2014-02-03 | 2020-05-08 | 俄亥俄州创新基金会 | 硼酸酯和其药物制剂 |
WO2015151775A1 (ja) * | 2014-03-31 | 2015-10-08 | 富士フイルム株式会社 | 水分解用光電極、水分解装置 |
AU2015264272A1 (en) | 2014-05-20 | 2016-11-24 | Millennium Pharmaceuticals, Inc. | Boron-containing proteasome inhibitors for use after primary cancer therapy |
EP3177292B1 (en) | 2014-08-07 | 2020-11-25 | Mayo Foundation for Medical Education and Research | Compounds and methods for treating cancer |
WO2016069955A1 (en) * | 2014-10-29 | 2016-05-06 | Wisconsin Alumni Research Foundation | Boronic acid inhibitors of hiv protease |
EP3031811A1 (en) | 2014-12-09 | 2016-06-15 | Teva Pharmaceuticals Ltd. | Malic acid esters of bortezomib |
MA41505A (fr) * | 2015-02-11 | 2017-12-19 | Millennium Pharm Inc | Nouvelle forme cristalline d'un inhibiteur de protéasome |
MA41555A (fr) * | 2015-02-17 | 2017-12-26 | Millennium Pharm Inc | Polythérapie pour le traitement du cancer |
CZ2015233A3 (cs) | 2015-04-03 | 2016-10-12 | Zentiva, K.S. | Způsob přípravy Ixazomib citrátu |
CZ2015253A3 (cs) | 2015-04-15 | 2016-10-26 | Zentiva, K.S. | Nové formy Ixazomib citrátu |
EP3310360B1 (en) * | 2015-06-19 | 2024-03-27 | Beijing Artivila BioPharma Co. Ltd. | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis |
WO2016205790A2 (en) * | 2015-06-19 | 2016-12-22 | Hanlin Scientific, Inc. | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis |
EP3120837A1 (de) | 2015-07-22 | 2017-01-25 | Stada Arzneimittel Ag | Verfahren zur herstellung einer bortezomibester-lösung |
EP3120836A1 (de) | 2015-07-22 | 2017-01-25 | Stada Arzneimittel Ag | Gebrauchsfertige bortezomib-lösung |
WO2017046815A1 (en) * | 2015-09-16 | 2017-03-23 | Mylan Laboratories Limited | Polymorphs of ixazomib citrate and processes for the preparation thereof |
CN106608883A (zh) * | 2015-10-21 | 2017-05-03 | 北京大学 | 蛋白酶体抑制剂mln9708的合成方法 |
US11268154B2 (en) | 2015-11-04 | 2022-03-08 | Takeda Pharmaceutical Company Limited | Methods for the identification, evaluation and treatment of patients having multiple myeloma |
CN106986884A (zh) * | 2016-01-20 | 2017-07-28 | 成都贝斯凯瑞生物科技有限公司 | 一种高效的高纯度含硼化合物制备方法 |
CN105622658B (zh) * | 2016-03-18 | 2018-06-19 | 中国药科大学 | 非肽类蛋白酶体抑制剂、其药物组合物、制备方法和应用 |
WO2017163190A1 (en) * | 2016-03-23 | 2017-09-28 | Dr. Reddy’S Laboratories Limited | Amorphous ixazomib citrate and solid dispersion thereof |
CN107224569A (zh) * | 2016-03-26 | 2017-10-03 | 复旦大学 | 一种硼替佐米水溶性药用组合物及其制备方法和用途 |
CZ2016204A3 (cs) | 2016-04-08 | 2017-11-01 | Zentiva, K.S. | Formulace Ixazomib citrátu formy 3 |
EP3798224A1 (en) * | 2016-06-21 | 2021-03-31 | Teva Pharmaceuticals International GmbH | Solid state forms of ixazomib citrate |
US10995103B2 (en) | 2016-07-25 | 2021-05-04 | Shenzhen Targetrx, Inc. | Substituted boric acid compound, pharmaceutical composition comprising same, and application thereof |
CA3032011A1 (en) * | 2016-08-04 | 2018-02-08 | Millennium Pharmaceuticals, Inc. | Combination of proteasome inhibitors and anti-cd30 antibodies |
TW201831191A (zh) * | 2017-01-23 | 2018-09-01 | 大陸商成都奥璟生物科技有限公司 | 一種新的硼酸衍生物及其藥物組合物 |
WO2018160717A1 (en) | 2017-02-28 | 2018-09-07 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
WO2018158697A1 (en) | 2017-03-03 | 2018-09-07 | Fresenius Kabi Oncology Limited | A process for the preparation of ixazomib citrate |
WO2018173071A1 (en) * | 2017-03-20 | 2018-09-27 | Msn Laboratories Private Limited, R&D Center | Novel crystalline forms of ixazomib citrate and its process for preparation thereof |
CN106916177B (zh) * | 2017-03-23 | 2019-04-23 | 南京陵瑞医药科技有限公司 | 一种氘代的二肽硼酸或其酯类化合物及其合成方法与用途 |
CN108794516A (zh) * | 2017-04-26 | 2018-11-13 | 上海时莱生物技术有限公司 | 硼酸和硼酸酯类化合物及其制备方法和用途 |
CN108794520B (zh) * | 2017-05-02 | 2020-07-24 | 北京大学 | 包括埃沙佐米在内的硼酸柠檬酸酯类化合物的合成方法 |
CN109305980B (zh) * | 2017-07-28 | 2022-10-11 | 成都奥璟生物科技有限公司 | 一种硼酸酯化合物、其合成方法及其用途 |
PT3672977T (pt) | 2017-08-24 | 2022-09-23 | Merck Patent Gmbh | Derivados do ácido borónico |
US20200199159A1 (en) | 2017-08-25 | 2020-06-25 | Synthon B.V. | Process for making ixazomib or intermediates therefor |
CA3074247A1 (en) * | 2017-09-02 | 2019-03-07 | Sun Pharmaceutical Industries Limited | Process for the preparation of ixazomib citrate |
CA3075714A1 (en) | 2017-09-14 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
CN109251218B (zh) * | 2017-12-05 | 2021-08-24 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的硼酸酯化合物的制备方法及其晶型 |
US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
US10118937B1 (en) | 2018-01-03 | 2018-11-06 | Scinopharm Taiwan, Ltd. | Process for preparing ixazomib citrate and intermediates therefor |
CN110041353A (zh) * | 2018-01-16 | 2019-07-23 | 成都译山生物科技有限公司 | 一种新的硼酸水杨酸酯类衍生物及其药物组合物 |
US11243207B2 (en) | 2018-03-29 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Assessing and treating cancer |
CN110540547A (zh) * | 2018-05-28 | 2019-12-06 | 秦艳茹 | 一种肽硼酸酯类化合物的合成与用途 |
JP2021531310A (ja) | 2018-07-26 | 2021-11-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | ボロン酸誘導体 |
TWI810344B (zh) | 2018-08-02 | 2023-08-01 | 大陸商正大天晴藥業集團股份有限公司 | 氮雜環丁烷衍生物的硼酸酯 |
CN115403603A (zh) * | 2018-09-14 | 2022-11-29 | 成都奥璟生物科技有限公司 | 一种硼酸酯类药物及其用途 |
CN110357787A (zh) * | 2019-08-02 | 2019-10-22 | 苏州艾和医药科技有限公司 | 依沙佐米合成工艺研究 |
WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
WO2024006337A1 (en) | 2022-06-30 | 2024-01-04 | Principia Biopharma Inc. | Cyclic boronic esters and their uses |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US449082A (en) * | 1891-03-24 | milbeadt | ||
US2160413A (en) | 1935-04-16 | 1939-05-30 | Schering Ag | Polyiodo derivatives of acylamino acids and their salts and a method of making the same |
NZ203706A (en) | 1982-04-22 | 1986-03-14 | Squibb & Sons Inc | Occlusive multi-layer wound dressing and hydrocolloidal granules for wound treatment |
US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
JPS6197352A (ja) * | 1984-10-17 | 1986-05-15 | Dai Ichi Kogyo Seiyaku Co Ltd | 安定性に優れた組成物 |
JPS6233170A (ja) | 1985-08-07 | 1987-02-13 | Tokuyama Soda Co Ltd | 環状ポリエ−テル化合物 |
JPH0813759B2 (ja) | 1986-09-01 | 1996-02-14 | 富士写真フイルム株式会社 | アルコキシベンゼン誘導体の製造方法 |
JP2512303B2 (ja) | 1987-03-20 | 1996-07-03 | 呉羽化学工業株式会社 | 2−オキサゾリン−4,5−ジオンのフエニルヒドラゾン誘導体 |
US5242904A (en) * | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
US5250720A (en) | 1987-06-05 | 1993-10-05 | The Dupont Merck Pharmaceutical Company | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases |
US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
EP0315574A3 (de) | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
US5106948A (en) * | 1988-05-27 | 1992-04-21 | Mao Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
US5159060A (en) * | 1988-05-27 | 1992-10-27 | Mayo Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
DE3827340A1 (de) | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
MX9206628A (es) | 1991-11-22 | 1993-05-01 | Boehringer Ingelheim Pharma | Ester de prolinaboronato y metodo para su preparacion. |
US5442100A (en) * | 1992-08-14 | 1995-08-15 | The Procter & Gamble Company | β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids |
ATE149563T1 (de) | 1992-08-14 | 1997-03-15 | Procter & Gamble | Alpha-aminoborsäurehaltige flüssige waschmittel |
US5492900A (en) * | 1993-09-10 | 1996-02-20 | Neutron Technology Corporation | Method for enhancing the solubility of the boron delivery drug, boronophenylalanine (BPA) |
US5935944A (en) * | 1993-09-10 | 1999-08-10 | Neutron Technology Corporation | Formulation for I.V. administration of the boron delivery drug, boronophenylalanine (BPA) |
US6060462A (en) * | 1993-10-20 | 2000-05-09 | Dupont Pharmaceuticals Company | Electrophilic peptide analogs as inhibitors of trypsin-like enzymes |
FR2712602B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
US5574017A (en) * | 1994-07-05 | 1996-11-12 | Gutheil; William G. | Antibacterial agents |
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US5614649A (en) | 1994-11-14 | 1997-03-25 | Cephalon, Inc. | Multicatalytic protease inhibitors |
JP3403009B2 (ja) | 1996-07-12 | 2003-05-06 | キヤノン株式会社 | 可動部材の変位と気泡成長を伴う液体吐出方法、該吐出方法に用いられる液体吐出ヘッド、ヘッドカートリッジ及びこれらを用いた液体吐出装置 |
US5834487A (en) | 1996-09-24 | 1998-11-10 | Cv Therapeutics | Inhibition of 26S and 20S proteasome by indanones |
AU741802B2 (en) | 1997-02-15 | 2001-12-13 | Millennium Pharmaceuticals, Inc. | Treatment of infarcts through inhibition of NF-kappaB |
JP2001517631A (ja) | 1997-09-25 | 2001-10-09 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 炎症疾患および自己免疫疾患を治療するためのプロテアソーム阻害剤、ユビキチン経路阻害剤、またはユビキチンプロテアソーム経路を介したNF−κBの活性化に干渉する剤 |
CA2314259A1 (en) | 1997-12-16 | 1999-06-24 | Robert Siman | Multicatalytic protease inhibitors for use as anti-tumor agents |
US6075150A (en) | 1998-01-26 | 2000-06-13 | Cv Therapeutics, Inc. | α-ketoamide inhibitors of 20S proteasome |
AU6229699A (en) | 1998-10-26 | 2000-05-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-amyloid formation inhibitors |
US6169076B1 (en) * | 1999-03-31 | 2001-01-02 | Glcosyn Pharmaceuticals, Inc. | P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols |
US6121149A (en) | 1999-04-22 | 2000-09-19 | Advanced Micro Devices, Inc. | Optimized trench/via profile for damascene filling |
KR100307027B1 (ko) | 1999-06-17 | 2001-11-01 | 서평원 | 액정 표시장치 및 이것을 이용한 이동 통신 단말기의 표시장치 |
CA2376965A1 (en) | 1999-07-07 | 2001-01-11 | Timothy Patrick Forsyth | Peptide boronic acid inhibitors of hepatitis c virus protease |
SE0100714D0 (sv) | 2000-07-13 | 2001-02-28 | Ap Biotech Ab | Reaction vessel and method for distributing fluid in such a vessel |
US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
JP2002145848A (ja) * | 2000-11-10 | 2002-05-22 | Kyorin Pharmaceut Co Ltd | アルケニルアミノ酸誘導体及びその製造法 |
EP1217000A1 (en) * | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
EP3078667B1 (en) * | 2001-01-25 | 2018-11-21 | The United States of America, represented by the Secretary, Department of Health and Human Services | Formulation of boronic acid compounds |
EP1399468B1 (en) | 2001-05-30 | 2006-02-15 | Novartis AG | 2-((n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl)-amino)-alkylboronic acid derivatives |
DE10131283A1 (de) | 2001-06-28 | 2003-01-09 | Philips Corp Intellectual Pty | Phased Array Antenne |
WO2003033507A1 (fr) | 2001-10-12 | 2003-04-24 | Kyorin Pharmaceutical Co., Ltd. | Derives d'acide benzylmalonique et inhibiteurs de proteasomes les contenant |
WO2003033506A1 (fr) | 2001-10-12 | 2003-04-24 | Kyorin Pharmaceutical Co., Ltd. | Derive d'acide d'aminoborane et medicament inhibiteur de proteasomes le contenant |
EP1463719A2 (en) | 2002-01-08 | 2004-10-06 | Eisai Co., Ltd | Eponemycin and epoxomicin analogs and uses thereof |
AU2003223930A1 (en) | 2002-06-14 | 2003-12-31 | Novo Nordisk A/S | Pharmaceutical use of boronic acids and esters thereof |
ATE325611T1 (de) | 2002-09-09 | 2006-06-15 | Trigen Ltd | Borsäuresalze und deren verwendung in der bereitstellung von medikamente für die thrombosebehandlung |
US20060084592A1 (en) | 2002-09-09 | 2006-04-20 | Trigen Limited | Peptide boronic acid inhibitors |
TW200418791A (en) | 2003-01-23 | 2004-10-01 | Bristol Myers Squibb Co | Pharmaceutical compositions for inhibiting proteasome |
US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
UA88771C2 (ru) * | 2003-08-14 | 2009-11-25 | Сефалон, Инк. | Ингибиторы протеасомы и способ их применения (варианты) |
GB0405267D0 (en) | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
DK3385267T3 (da) * | 2004-03-30 | 2021-11-01 | Millennium Pharm Inc | Syntese af boronestere og syreforbindelser |
PL2030981T3 (pl) | 2004-05-10 | 2014-12-31 | Onyx Therapeutics Inc | Związki do enzymatycznej inhibicji proteasomu |
WO2006008660A2 (en) | 2004-07-20 | 2006-01-26 | Affinium Pharmaceuticals, Inc. | Streptococcus pneumoniae enoyl- (acyl-carrier-protein) reductase (fabk) |
TW200618820A (en) | 2004-11-05 | 2006-06-16 | Alza Corp | Liposome formulations of boronic acid compounds |
US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
CN101120006A (zh) * | 2005-02-11 | 2008-02-06 | 赛福伦公司 | 蛋白酶体抑制剂及其使用方法 |
AU2006242446A1 (en) | 2005-04-29 | 2006-11-09 | Kosan Biosciences Incorporated | Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either in combination with a proteasome inhibitor |
KR20080030079A (ko) | 2005-07-05 | 2008-04-03 | 트러스티즈 오브 터프츠 칼리지 | 섬유아세포 활성 단백질 알파의 억제제 |
BRPI0619514A2 (pt) * | 2005-12-08 | 2011-10-04 | Millennium Pharm Inc | compostos bicìclicos com atividade inibidora cinase, composição farmacêutica contendo os mesmos e uso de ditos compostos |
EP2029153A2 (en) | 2006-01-27 | 2009-03-04 | Phenomix Corporation | Hepatitis c serine protease inhibitors and uses therefor |
EP1988083B1 (en) | 2006-02-03 | 2014-04-02 | Taisho Pharmaceutical Co., Ltd. | Triazole derivative |
CL2007002499A1 (es) * | 2006-08-30 | 2008-03-14 | Phenomix Corp | Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes. |
WO2009006473A2 (en) | 2007-07-05 | 2009-01-08 | Trustees Of Tufts College | Pro-soft polypeptide proteasome inhibitors, and methods of use thereof |
GEP20125599B (en) | 2007-08-06 | 2012-08-10 | Millennium Pharm Inc | Proteasome inhibitors |
US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
ITMI20072397A1 (it) | 2007-12-20 | 2009-06-21 | Gambro Lundia Ab | Apparecchiatura medicale per il trattamento extracorporeo |
DK2730581T3 (en) * | 2008-06-17 | 2016-08-15 | Millennium Pharm Inc | Boronate Ester Compounds and Pharmaceutical Compositions thereof. |
AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
CN102892291A (zh) | 2010-03-31 | 2013-01-23 | 米伦纽姆医药公司 | 1-氨基-2-环丙基乙硼酸衍生物 |
WO2012148336A1 (en) | 2011-04-29 | 2012-11-01 | Telefonaktiebolaget L M Ericsson (Publ) | Decentralised control of interference reduction in a wireless communication system |
JP5724951B2 (ja) | 2012-06-11 | 2015-05-27 | 日立金属株式会社 | ネットワーク管理装置 |
JP6357023B2 (ja) | 2014-06-06 | 2018-07-11 | 任天堂株式会社 | 情報処理プログラム、情報処理装置、情報処理装置の制御方法および情報処理システム |
-
2009
- 2009-06-16 DK DK13191414.5T patent/DK2730581T3/en active
- 2009-06-16 CA CA2727862A patent/CA2727862C/en active Active
- 2009-06-16 KR KR1020117001181A patent/KR101691093B1/ko active IP Right Grant
- 2009-06-16 CN CN2013103491814A patent/CN103467565A/zh active Pending
- 2009-06-16 MX MX2013010325A patent/MX349769B/es unknown
- 2009-06-16 EA EA201500430A patent/EA030685B1/ru not_active IP Right Cessation
- 2009-06-16 MX MX2013010326A patent/MX340186B/es unknown
- 2009-06-16 WO PCT/US2009/003602 patent/WO2009154737A1/en active Application Filing
- 2009-06-16 DK DK09767050.9T patent/DK2318419T3/en active
- 2009-06-16 PT PT97670509T patent/PT2318419E/pt unknown
- 2009-06-16 KR KR1020147019858A patent/KR101704694B1/ko active IP Right Grant
- 2009-06-16 NZ NZ603236A patent/NZ603236A/en unknown
- 2009-06-16 CN CN201710292950.XA patent/CN107253966A/zh active Pending
- 2009-06-16 GE GEAP2009012060 patent/GEP20135847B/en unknown
- 2009-06-16 CN CN201710333805.1A patent/CN107253975A/zh active Pending
- 2009-06-16 KR KR1020177013867A patent/KR101860743B1/ko active IP Right Grant
- 2009-06-16 ES ES13191414.5T patent/ES2585114T3/es active Active
- 2009-06-16 NZ NZ624121A patent/NZ624121A/en not_active IP Right Cessation
- 2009-06-16 CN CN201310349618.4A patent/CN103497210A/zh active Pending
- 2009-06-16 SG SG10201701524XA patent/SG10201701524XA/en unknown
- 2009-06-16 RS RS20150366A patent/RS54020B1/en unknown
- 2009-06-16 CN CN201310349472.3A patent/CN103497232A/zh active Pending
- 2009-06-16 EA EA201170036A patent/EA027346B1/ru not_active IP Right Cessation
- 2009-06-16 KR KR1020147019854A patent/KR101690571B1/ko active IP Right Grant
- 2009-06-16 EA EA201500431A patent/EA201500431A1/ru unknown
- 2009-06-16 JP JP2011514598A patent/JP5566380B2/ja active Active
- 2009-06-16 PL PL09767050T patent/PL2318419T3/pl unknown
- 2009-06-16 CN CN201710264997.5A patent/CN107266480A/zh active Pending
- 2009-06-16 BR BR122014008753A patent/BR122014008753A2/pt not_active Application Discontinuation
- 2009-06-16 MY MYPI2010005940A patent/MY155592A/en unknown
- 2009-06-16 UA UAA201403777A patent/UA115131C2/uk unknown
- 2009-06-16 EP EP09767050.9A patent/EP2318419B1/en active Active
- 2009-06-16 CN CN201310349247XA patent/CN103450241A/zh active Pending
- 2009-06-16 SG SG2013069851A patent/SG194349A1/en unknown
- 2009-06-16 GE GEAP200912730A patent/GEP201706703B/en unknown
- 2009-06-16 ES ES09767050.9T patent/ES2541467T3/es active Active
- 2009-06-16 US US12/485,344 patent/US20090325903A1/en not_active Abandoned
- 2009-06-16 CN CN2013103488135A patent/CN103435638A/zh active Pending
- 2009-06-16 PT PT131914145T patent/PT2730581T/pt unknown
- 2009-06-16 NZ NZ624123A patent/NZ624123A/en unknown
- 2009-06-16 CN CN2009801230135A patent/CN102066386A/zh active Pending
- 2009-06-16 BR BR122014008754A patent/BR122014008754A2/pt not_active Application Discontinuation
- 2009-06-16 KR KR1020147019860A patent/KR101741142B1/ko active IP Right Grant
- 2009-06-16 SI SI200931201T patent/SI2318419T1/sl unknown
- 2009-06-16 EP EP13191413.7A patent/EP2733147A1/en not_active Withdrawn
- 2009-06-16 EP EP13191414.5A patent/EP2730581B1/en not_active Revoked
- 2009-06-16 BR BR122014008750A patent/BR122014008750A2/pt not_active Application Discontinuation
- 2009-06-16 AU AU2009260778A patent/AU2009260778B2/en active Active
- 2009-06-16 MX MX2010013642A patent/MX2010013642A/es active IP Right Grant
- 2009-06-16 NZ NZ624122A patent/NZ624122A/en unknown
- 2009-06-16 BR BRPI0915300A patent/BRPI0915300C1/pt active IP Right Grant
- 2009-06-16 EP EP13191409.5A patent/EP2730579A1/en not_active Withdrawn
- 2009-06-16 MY MYPI2014003632A patent/MY171021A/en unknown
- 2009-06-16 EA EA201500432A patent/EA201500432A1/ru unknown
- 2009-06-16 CN CN201710312608.1A patent/CN107266482A/zh active Pending
- 2009-06-16 EP EP19150417.4A patent/EP3536693A1/en active Pending
- 2009-06-16 MX MX2017014406A patent/MX358222B/es unknown
- 2009-06-16 EP EP20130191412 patent/EP2730580A1/en not_active Withdrawn
- 2009-06-16 CA CA2921946A patent/CA2921946C/en active Active
- 2009-06-17 TW TW098120303A patent/TWI498333B/zh active
- 2009-06-17 PE PE2014000152A patent/PE20141076A1/es not_active Application Discontinuation
- 2009-06-17 TW TW103118482A patent/TWI542351B/zh not_active IP Right Cessation
- 2009-06-17 PE PE2014000151A patent/PE20141078A1/es not_active Application Discontinuation
- 2009-06-17 PE PE2014000150A patent/PE20141064A1/es not_active Application Discontinuation
- 2009-06-17 TW TW103118480A patent/TWI543985B/zh active
- 2009-06-17 PE PE2014000153A patent/PE20141065A1/es not_active Application Discontinuation
- 2009-06-17 AR ARP090102187A patent/AR072162A1/es active IP Right Grant
- 2009-06-17 PE PE2009000877A patent/PE20100256A1/es active IP Right Grant
-
2010
- 2010-12-10 DO DO2010000384A patent/DOP2010000384A/es unknown
- 2010-12-16 CR CR11850A patent/CR11850A/es unknown
- 2010-12-16 IL IL210056A patent/IL210056B/en active IP Right Grant
- 2010-12-17 CL CL2010001475A patent/CL2010001475A1/es unknown
- 2010-12-21 ZA ZA2010/09177A patent/ZA201009177B/en unknown
- 2010-12-23 CO CO10161489A patent/CO6321289A2/es active IP Right Grant
-
2011
- 2011-01-13 MA MA33514A patent/MA32471B1/fr unknown
- 2011-01-17 EC EC2011010763A patent/ECSP11010763A/es unknown
- 2011-11-07 HK HK14111716.4A patent/HK1198254A1/xx unknown
- 2011-11-07 HK HK14111510.2A patent/HK1199260A1/zh not_active IP Right Cessation
- 2011-11-07 HK HK14111508.6A patent/HK1198252A1/xx unknown
- 2011-11-07 HK HK14111509.5A patent/HK1198253A1/xx unknown
- 2011-11-07 HK HK11111993.1A patent/HK1157786A1/xx unknown
- 2011-12-20 ZA ZA2011/09368A patent/ZA201109368B/en unknown
-
2012
- 2012-11-02 US US13/667,164 patent/US8859504B2/en active Active
-
2013
- 2013-06-25 ZA ZA2013/04728A patent/ZA201304728B/en unknown
-
2014
- 2014-05-14 EC ECSP14010763 patent/ECSP14010763A/es unknown
- 2014-05-19 JP JP2014103398A patent/JP2014169317A/ja not_active Withdrawn
- 2014-05-19 JP JP2014103396A patent/JP6110813B2/ja active Active
- 2014-05-19 JP JP2014103397A patent/JP5926319B2/ja active Active
- 2014-05-19 JP JP2014103395A patent/JP6010066B2/ja active Active
- 2014-08-01 US US14/449,328 patent/US9175018B2/en active Active
- 2014-08-01 US US14/449,275 patent/US9175017B2/en active Active
- 2014-08-25 IL IL234285A patent/IL234285B/en active IP Right Grant
- 2014-08-25 IL IL234286A patent/IL234286A/en active IP Right Grant
-
2015
- 2015-05-27 PH PH12015501192A patent/PH12015501192A1/en unknown
- 2015-05-27 PH PH12015501193A patent/PH12015501193A1/en unknown
- 2015-05-27 PH PH12015501191A patent/PH12015501191B1/en unknown
- 2015-06-02 HR HRP20150592TT patent/HRP20150592T1/hr unknown
- 2015-06-08 ZA ZA2015/04133A patent/ZA201504133B/en unknown
- 2015-06-16 CY CY20151100519T patent/CY1116435T1/el unknown
- 2015-10-12 US US14/880,776 patent/US20160031913A1/en not_active Abandoned
-
2016
- 2016-01-08 CR CR20160014A patent/CR20160014A/es unknown
- 2016-01-08 CR CR20160015A patent/CR20160015A/es unknown
-
2017
- 2017-05-04 NO NO2017016C patent/NO2017016I1/no unknown
- 2017-06-30 JP JP2017128843A patent/JP2017214396A/ja not_active Withdrawn
- 2017-09-12 US US15/701,791 patent/US20180002350A1/en not_active Abandoned
-
2018
- 2018-03-22 US US15/928,139 patent/US20180208609A1/en not_active Abandoned
- 2018-03-27 HK HK18104202.6A patent/HK1244827A1/zh unknown
- 2018-03-27 HK HK18104204.4A patent/HK1244811A1/zh unknown
- 2018-03-27 HK HK18104201.7A patent/HK1244809A1/zh unknown
- 2018-03-27 HK HK18104203.5A patent/HK1244810A1/zh unknown
- 2018-10-18 US US16/163,694 patent/US20190048028A1/en not_active Abandoned
-
2019
- 2019-01-29 US US16/260,596 patent/US10526351B2/en active Active
- 2019-05-08 US US16/406,159 patent/US20190263839A1/en not_active Abandoned
- 2019-09-13 US US16/570,065 patent/US10604538B2/en active Active
- 2019-11-29 JP JP2019216272A patent/JP2020055829A/ja not_active Withdrawn
-
2020
- 2020-02-12 US US16/788,824 patent/US20200181176A1/en not_active Abandoned
- 2020-04-24 US US16/857,227 patent/US11485746B2/en active Active
- 2020-09-01 US US17/009,199 patent/US20200392164A1/en not_active Abandoned
-
2021
- 2021-03-11 US US17/198,442 patent/US20210198289A1/en not_active Abandoned
- 2021-07-01 JP JP2021109909A patent/JP2021165288A/ja not_active Withdrawn
- 2021-09-23 US US17/483,724 patent/US20220009948A1/en not_active Abandoned
-
2023
- 2023-05-03 US US18/311,290 patent/US20230265111A1/en not_active Abandoned
- 2023-09-07 JP JP2023145377A patent/JP2023158150A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR072162A1 (es) | Compuestos de ester boronato y composiciones farmaceuticas de los mismos | |
BR112014006840A2 (pt) | derivados de pirrolopirimidina e purina | |
CA2875877C (en) | Syk inhibitors | |
AR075090A1 (es) | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. | |
EA201391239A1 (ru) | Пирроло[2,3-d]пиримидиновые производные в качестве ингибиторов тропомиозин-связанных киназ | |
ECSP11010879A (es) | Inhibidores macrocíclicos de serina proteasas de hepatitis c | |
AR078522A1 (es) | Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis | |
NZ630259A (en) | Heterobicyclic compounds as beta-lactamase inhibitors | |
NZ630457A (en) | Compounds useful as inhibitors of atr kinase | |
AR069510A1 (es) | Arilo y heteroarilo imidazo[1,5-a]pirazinas fusionadas como inhibidores de la fosfodiesterasa 10 | |
CO6220972A2 (es) | Derivados de 6-amino dihidropurin -8-ona utiles como agentes terapeuticos y/o preventivos para el tratamiento de enfermedades alergicas, virales o cancer | |
BR112013023876A2 (pt) | derivados de pirroltriazinona como inibidores de pi3k | |
NZ608720A (en) | Macrocyclic proline derived hcv serine protease inhibitors | |
AR088029A1 (es) | Compuestos de pirimidina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento del dolor, accidentes cerebrovasculares, epilepsia y otras enfermedades del sistema nervioso central | |
HRP20110885T1 (hr) | Makrociklički inhibitori virusa hepatitisa c | |
BRPI1009333B8 (pt) | compostos inibidores de beta-secretase, seus usos, bem como composição farmacêutica | |
AR086086A1 (es) | Derivados glucosidos y usos de los mismos | |
UY31639A1 (es) | Derivados de amida espirocíclica de fórmula i, sales farmacéuticamente aceptables, composiciones farmacéuticas conteniéndolas, procesos de preparación y aplicaciones | |
ECSP067111A (es) | Derivados de pirido-pirimidina, su preparación, su aplicación en terapéutica | |
BR112015003380A2 (pt) | composto de pirazolopirimidina | |
DK2041133T3 (da) | Derivater af imadazol [1,2-A] pyridine-2-carboxamider, fremstilling deraf og anvendelse deraf i terapeutik | |
AR086676A1 (es) | Derivados de alcoholes 1-fenil-2-piridinil alquilicos como inhibidores de fosfodiesterasa | |
EA201490726A1 (ru) | Фармацевтические соединения для применения в терапии инфекции clostridium difficile | |
AR077534A1 (es) | Derivados de isoxazol, un proceso para su obtencion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades relacionadas con el receptor gaba aalfa5 | |
AR082968A1 (es) | Inhibidores biciclicos de notum pectinacetilesterasa y una composicion farmaceutica en base al compuesto |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |