MA34133B1 - Composes pour inhibiteurs de l'immunoproteasome - Google Patents
Composes pour inhibiteurs de l'immunoproteasomeInfo
- Publication number
- MA34133B1 MA34133B1 MA35248A MA35248A MA34133B1 MA 34133 B1 MA34133 B1 MA 34133B1 MA 35248 A MA35248 A MA 35248A MA 35248 A MA35248 A MA 35248A MA 34133 B1 MA34133 B1 MA 34133B1
- Authority
- MA
- Morocco
- Prior art keywords
- immunoproteasome
- inhibitors
- compounds
- relates
- administering
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
Abstract
Selon un aspect de l'invention, celle-ci concerne des inhibiteurs qui inhibent préférentiellement l'activité de l'immunoprotéasome plutôt que l'activité du protéasome constitutif. Dans certains modes de réalisation, l'invention concerne le traitement de maladies liées à l'immunité, comportant l'administration d'un composé de l'invention. Dans certains modes de réalisation, l'invention concerne le traitement du cancer, comportant l'administration d'un composé de l'invention.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30936610P | 2010-03-01 | 2010-03-01 | |
PCT/US2011/026629 WO2011109355A1 (fr) | 2010-03-01 | 2011-03-01 | Composés pour inhibition de l'immunoprotéasome |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34133B1 true MA34133B1 (fr) | 2013-04-03 |
Family
ID=43983939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35248A MA34133B1 (fr) | 2010-03-01 | 2011-03-01 | Composes pour inhibiteurs de l'immunoproteasome |
Country Status (20)
Country | Link |
---|---|
US (1) | US9359398B2 (fr) |
EP (1) | EP2542238B1 (fr) |
JP (1) | JP6042724B2 (fr) |
KR (1) | KR20130075723A (fr) |
CN (1) | CN102892417A (fr) |
AU (1) | AU2011223795B2 (fr) |
BR (1) | BR112012022060A2 (fr) |
CA (1) | CA2791651C (fr) |
CL (1) | CL2012002404A1 (fr) |
CO (1) | CO6612265A2 (fr) |
CR (1) | CR20120451A (fr) |
CU (1) | CU20120125A7 (fr) |
DO (1) | DOP2012000238A (fr) |
EA (1) | EA201290844A1 (fr) |
EC (1) | ECSP12012140A (fr) |
MA (1) | MA34133B1 (fr) |
MX (1) | MX2012010017A (fr) |
SG (1) | SG183843A1 (fr) |
WO (1) | WO2011109355A1 (fr) |
ZA (1) | ZA201206479B (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2623113T3 (en) * | 2005-11-09 | 2017-07-17 | Onyx Therapeutics Inc | Enzyme inhibition compound |
RU2450016C2 (ru) | 2006-06-19 | 2012-05-10 | Протеоликс, Инк. | Пептидные эпоксикетоны для ингибирования протеасомы |
PT2207791T (pt) | 2007-10-04 | 2016-07-12 | Onyx Therapeutics Inc | Inibidores da epoxi cetona protease de péptido cristalino e a síntese de ceto-epóxidos de aminoácidos |
KR20110073584A (ko) * | 2008-10-21 | 2011-06-29 | 오닉스 세라퓨틱스, 인크. | 펩티드 에폭시케톤과의 병용 요법 |
AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
EP2498793B1 (fr) | 2009-11-13 | 2019-07-10 | Onyx Therapeutics, Inc. | Oprozomib pour l'utilsation dans la suppression des metastases |
BR112012022060A2 (pt) * | 2010-03-01 | 2018-05-08 | Onyx Therapeutics Inc | composto para a inibição de imunoproteassoma |
SG185359A1 (en) | 2010-04-07 | 2012-12-28 | Onyx Therapeutics Inc | Crystalline peptide epoxyketone immunoproteasome inhibitor |
WO2014011695A2 (fr) | 2012-07-09 | 2014-01-16 | Onyx Therapeutics, Inc. | Promédicaments d'inhibiteurs d'époxy cétone protéase peptidique |
ES2615744T3 (es) * | 2012-12-03 | 2017-06-08 | F. Hoffmann-La Roche Ag | Compuestos de ácido triazol-borónico sustituidos |
EP2970225B1 (fr) * | 2013-03-14 | 2018-08-15 | Onyx Therapeutics, Inc. | Dipeptides et tripeptides inhibiteurs d'epoxy cetone protease |
KR20150132362A (ko) * | 2013-03-15 | 2015-11-25 | 에이다에레이타, 리미티드 파트너쉽 | Pcsk9의 소분자 조절물질 및 그것의 사용 방법 |
US9988421B2 (en) | 2014-01-10 | 2018-06-05 | Cornell University | Dipeptides as inhibitors of human immunoproteasomes |
CN103804469B (zh) * | 2014-02-17 | 2016-04-06 | 苏州明锐医药科技有限公司 | 卡非佐米中间体的制备方法 |
CN107073069B (zh) | 2014-08-18 | 2022-03-08 | 康奈尔大学 | 作为人免疫蛋白酶体的抑制剂的二肽模拟物 |
EP3201208B1 (fr) * | 2014-10-01 | 2021-03-24 | Merck Patent GmbH | Dérivés d'acide boronique |
CN108351169B (zh) | 2015-10-15 | 2022-01-28 | 康奈尔大学 | 蛋白酶体抑制剂及其用途 |
CN106588965A (zh) * | 2015-10-15 | 2017-04-26 | 北京大学 | 脲拟肽硼酸化合物及其药物组合物、制备方法和用途 |
US10526315B2 (en) | 2016-06-21 | 2020-01-07 | Orion Ophthalmology LLC | Carbocyclic prolinamide derivatives |
FI3472149T3 (fi) | 2016-06-21 | 2023-11-09 | Orion Ophthalmology LLC | Heterosyklisiä prolinamidijohdannaisia |
US11203613B2 (en) | 2017-10-11 | 2021-12-21 | Cornell University | Peptidomimetic proteasome inhibitors |
MX2020005046A (es) * | 2017-11-16 | 2020-08-20 | Principia Biopharma Inc | Inhibidores de inmunoproteasoma. |
CN111344018A (zh) * | 2017-11-16 | 2020-06-26 | 美国安进公司 | 聚乙二醇化卡非佐米化合物的稳定的组合物 |
LV15544A (lv) * | 2019-07-01 | 2021-01-20 | Latvijas Organiskās Sintēzes Institūts | Jauni borskābi saturoši peptidomimētiķi kā malārijas serīna proteāzes inhibitori |
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-
2011
- 2011-03-01 BR BR112012022060A patent/BR112012022060A2/pt not_active IP Right Cessation
- 2011-03-01 AU AU2011223795A patent/AU2011223795B2/en active Active
- 2011-03-01 CN CN201180022010XA patent/CN102892417A/zh active Pending
- 2011-03-01 KR KR1020127025901A patent/KR20130075723A/ko not_active Application Discontinuation
- 2011-03-01 CA CA2791651A patent/CA2791651C/fr active Active
- 2011-03-01 MX MX2012010017A patent/MX2012010017A/es active IP Right Grant
- 2011-03-01 US US13/580,112 patent/US9359398B2/en active Active
- 2011-03-01 EP EP11715320.5A patent/EP2542238B1/fr active Active
- 2011-03-01 SG SG2012064531A patent/SG183843A1/en unknown
- 2011-03-01 WO PCT/US2011/026629 patent/WO2011109355A1/fr active Application Filing
- 2011-03-01 MA MA35248A patent/MA34133B1/fr unknown
- 2011-03-01 JP JP2012556160A patent/JP6042724B2/ja active Active
- 2011-03-01 EA EA201290844A patent/EA201290844A1/ru unknown
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2012
- 2012-08-28 ZA ZA2012/06479A patent/ZA201206479B/en unknown
- 2012-08-29 DO DO2012000238A patent/DOP2012000238A/es unknown
- 2012-08-30 CU CU2012000125A patent/CU20120125A7/es unknown
- 2012-08-30 CR CR20120451A patent/CR20120451A/es unknown
- 2012-08-31 CL CL2012002404A patent/CL2012002404A1/es unknown
- 2012-09-04 EC ECSP12012140 patent/ECSP12012140A/es unknown
- 2012-09-28 CO CO12170402A patent/CO6612265A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CO6612265A2 (es) | 2013-02-01 |
BR112012022060A2 (pt) | 2018-05-08 |
CA2791651C (fr) | 2019-08-20 |
US9359398B2 (en) | 2016-06-07 |
EP2542238A1 (fr) | 2013-01-09 |
US20130072422A1 (en) | 2013-03-21 |
SG183843A1 (en) | 2012-10-30 |
CL2012002404A1 (es) | 2012-12-21 |
ZA201206479B (en) | 2015-08-26 |
AU2011223795B2 (en) | 2015-11-05 |
ECSP12012140A (es) | 2012-10-30 |
JP6042724B2 (ja) | 2016-12-14 |
DOP2012000238A (es) | 2013-01-15 |
JP2013521295A (ja) | 2013-06-10 |
CA2791651A1 (fr) | 2011-09-09 |
AU2011223795A1 (en) | 2012-09-20 |
KR20130075723A (ko) | 2013-07-05 |
EA201290844A1 (ru) | 2013-03-29 |
EP2542238B1 (fr) | 2015-08-12 |
CU20120125A7 (es) | 2012-11-15 |
CR20120451A (es) | 2012-10-16 |
WO2011109355A1 (fr) | 2011-09-09 |
MX2012010017A (es) | 2012-10-01 |
CN102892417A (zh) | 2013-01-23 |
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