ECSP14010763A - Compuestos de ester boronato y composiciones farmaceuticas de los mismos - Google Patents

Compuestos de ester boronato y composiciones farmaceuticas de los mismos

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Publication number
ECSP14010763A
ECSP14010763A ECSP14010763A ECSP14010763A EC SP14010763 A ECSP14010763 A EC SP14010763A EC SP14010763 A ECSP14010763 A EC SP14010763A EC SP14010763 A ECSP14010763 A EC SP14010763A
Authority
EC
Ecuador
Prior art keywords
pharmaceutical compositions
compounds
same
compositions
ester boronate
Prior art date
Application number
Other languages
English (en)
Inventor
Eric L Elliott
Abu J Ferdous
Michael J Kaufman
Sonja A Komar
Debra L Mazaik
Quentin J Mccubbin
Vaithianathan Palaniapan
Raymond D Skwierczynski
Nobel T Truong
Csanad Varga
Peter N Zawaneh
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41061278&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP14010763(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of ECSP14010763A publication Critical patent/ECSP14010763A/es

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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invención provee compuestos novedosos La presente invención provee compuestos novedosos La presente invención provee compuestos novedosos útiles como inhibidores de proteasoma. La invencióútiles como inhibidores de proteasoma. La invencióútiles como inhibidores de proteasoma. La invención además provee composiciones farmacéuticas que con además provee composiciones farmacéuticas que con además provee composiciones farmacéuticas que comprenden los compuestos de la invención y métodos mprenden los compuestos de la invención y métodos mprenden los compuestos de la invención y métodos para utilizar las composiciones en el tratamiento para utilizar las composiciones en el tratamiento para utilizar las composiciones en el tratamiento de varias enfermedades. de varias enfermedades. de varias enfermedades.
ECSP14010763 2008-06-17 2014-05-14 Compuestos de ester boronato y composiciones farmaceuticas de los mismos ECSP14010763A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13224408P 2008-06-17 2008-06-17
US21149909P 2009-03-31 2009-03-31

Publications (1)

Publication Number Publication Date
ECSP14010763A true ECSP14010763A (es) 2014-07-31

Family

ID=41061278

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2011010763A ECSP11010763A (es) 2008-06-17 2011-01-17 COMPUESTOS DE ÉSTER BORONATO y COMPOSICIONES FARMACÉUTICAS DE LOS MISMOS
ECSP14010763 ECSP14010763A (es) 2008-06-17 2014-05-14 Compuestos de ester boronato y composiciones farmaceuticas de los mismos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EC2011010763A ECSP11010763A (es) 2008-06-17 2011-01-17 COMPUESTOS DE ÉSTER BORONATO y COMPOSICIONES FARMACÉUTICAS DE LOS MISMOS

Country Status (38)

Country Link
US (17) US20090325903A1 (es)
EP (6) EP2730579A1 (es)
JP (9) JP5566380B2 (es)
KR (5) KR101690571B1 (es)
CN (10) CN107253966A (es)
AR (1) AR072162A1 (es)
AU (1) AU2009260778B2 (es)
BR (4) BR122014008753A2 (es)
CA (2) CA2727862C (es)
CL (1) CL2010001475A1 (es)
CO (1) CO6321289A2 (es)
CR (3) CR11850A (es)
CY (1) CY1116435T1 (es)
DK (2) DK2730581T3 (es)
DO (1) DOP2010000384A (es)
EA (4) EA201500432A1 (es)
EC (2) ECSP11010763A (es)
ES (2) ES2585114T3 (es)
GE (2) GEP201706703B (es)
HK (9) HK1198252A1 (es)
HR (1) HRP20150592T1 (es)
IL (3) IL210056B (es)
MA (1) MA32471B1 (es)
MX (4) MX349769B (es)
MY (2) MY155592A (es)
NO (1) NO2017016I1 (es)
NZ (4) NZ624122A (es)
PE (5) PE20141076A1 (es)
PH (3) PH12015501191A1 (es)
PL (1) PL2318419T3 (es)
PT (2) PT2318419E (es)
RS (1) RS54020B1 (es)
SG (2) SG194349A1 (es)
SI (1) SI2318419T1 (es)
TW (3) TWI543985B (es)
UA (1) UA115131C2 (es)
WO (1) WO2009154737A1 (es)
ZA (4) ZA201009177B (es)

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AU2009260778A1 (en) 2009-12-23
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CA2921946A1 (en) 2009-12-23
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US20200392164A1 (en) 2020-12-17
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CR20160014A (es) 2016-02-08
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US20130165390A1 (en) 2013-06-27
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US20200181176A1 (en) 2020-06-11
EA201170036A1 (ru) 2011-06-30
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AU2009260778B2 (en) 2014-08-28
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PE20100256A1 (es) 2010-04-14
US20140343314A1 (en) 2014-11-20
DK2730581T3 (en) 2016-08-15
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US20180002350A1 (en) 2018-01-04
PL2318419T3 (pl) 2015-08-31
PE20141064A1 (es) 2014-09-05
KR20140094663A (ko) 2014-07-30
EA201500430A1 (ru) 2015-11-30
TWI543985B (zh) 2016-08-01
MY171021A (en) 2019-09-23
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