WO2003033506A1 - Derive d'acide d'aminoborane et medicament inhibiteur de proteasomes le contenant - Google Patents
Derive d'acide d'aminoborane et medicament inhibiteur de proteasomes le contenant Download PDFInfo
- Publication number
- WO2003033506A1 WO2003033506A1 PCT/JP2002/010450 JP0210450W WO03033506A1 WO 2003033506 A1 WO2003033506 A1 WO 2003033506A1 JP 0210450 W JP0210450 W JP 0210450W WO 03033506 A1 WO03033506 A1 WO 03033506A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aminoborane
- acid derivative
- same
- proteasome inhibitory
- remedy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003536245A JPWO2003033506A1 (ja) | 2001-10-12 | 2002-10-08 | アミノボラン酸誘導体およびそれを含有するプロテアソーム阻害薬 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001314731 | 2001-10-12 | ||
JP2001-314731 | 2001-10-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003033506A1 true WO2003033506A1 (fr) | 2003-04-24 |
Family
ID=19132995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/010450 WO2003033506A1 (fr) | 2001-10-12 | 2002-10-08 | Derive d'acide d'aminoborane et medicament inhibiteur de proteasomes le contenant |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPWO2003033506A1 (fr) |
WO (1) | WO2003033506A1 (fr) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003059898A2 (fr) * | 2002-01-08 | 2003-07-24 | Eisai Co. Ltd. | Analogues d'eponemycine et d'epoxomicine et leurs utilisations |
JP2007502304A (ja) * | 2003-08-14 | 2007-02-08 | セファロン、インク. | プロテアソーム阻害剤及びそれらを使用する方法 |
EP2088205A1 (fr) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10 : marqueur de diagnostic et cible thérapeutique de rejet chronique |
CN102127052A (zh) * | 2011-01-25 | 2011-07-20 | 浙江大学 | 1,4-苯并二恶烷-2-羧酸的合成方法 |
KR101441703B1 (ko) | 2006-06-19 | 2014-09-17 | 오닉스 세라퓨틱스, 인크. | 프로테아좀 저해를 위한 펩티드 에폭시케톤 |
US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
JP2016172768A (ja) * | 2016-06-27 | 2016-09-29 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤 |
AU2016202747B2 (en) * | 2004-03-30 | 2017-11-23 | Millennium Pharmaceuticals, Inc. | Synthesis of boronic ester and acid compounds |
CN107474062A (zh) * | 2004-03-30 | 2017-12-15 | 千禧药品公司 | 硼的酯和酸化合物的合成 |
WO2018159628A1 (fr) * | 2017-02-28 | 2018-09-07 | 国立大学法人北海道大学 | Acylborane de type acide aminé et procédé pour sa production |
US10526351B2 (en) | 2008-06-17 | 2020-01-07 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
JP2021526159A (ja) * | 2018-05-28 | 2021-09-30 | チャンスー チア タイ フェンハイ ファーマシューティカル カンパニー リミテッドJiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd. | ペプチドボロン酸エステル類化合物の合成及び使用 |
US11241448B2 (en) | 2014-05-20 | 2022-02-08 | Millennium Pharmaceuticals, Inc. | Methods for cancer therapy |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
-
2002
- 2002-10-08 WO PCT/JP2002/010450 patent/WO2003033506A1/fr active Application Filing
- 2002-10-08 JP JP2003536245A patent/JPWO2003033506A1/ja not_active Ceased
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7524883B2 (en) | 2002-01-08 | 2009-04-28 | Eisai R&D Management Co., Ltd. | Eponemycin and epoxomicin analogs and uses thereof |
WO2003059898A3 (fr) * | 2002-01-08 | 2004-02-26 | Eisai Co Ltd | Analogues d'eponemycine et d'epoxomicine et leurs utilisations |
WO2003059898A2 (fr) * | 2002-01-08 | 2003-07-24 | Eisai Co. Ltd. | Analogues d'eponemycine et d'epoxomicine et leurs utilisations |
JP4917431B2 (ja) * | 2003-08-14 | 2012-04-18 | セファロン、インク. | プロテアソーム阻害剤及びそれらを使用する方法 |
JP2007502304A (ja) * | 2003-08-14 | 2007-02-08 | セファロン、インク. | プロテアソーム阻害剤及びそれらを使用する方法 |
AU2016202747B2 (en) * | 2004-03-30 | 2017-11-23 | Millennium Pharmaceuticals, Inc. | Synthesis of boronic ester and acid compounds |
CN107474062A (zh) * | 2004-03-30 | 2017-12-15 | 千禧药品公司 | 硼的酯和酸化合物的合成 |
KR101441703B1 (ko) | 2006-06-19 | 2014-09-17 | 오닉스 세라퓨틱스, 인크. | 프로테아좀 저해를 위한 펩티드 에폭시케톤 |
EP2088205A1 (fr) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10 : marqueur de diagnostic et cible thérapeutique de rejet chronique |
US10526351B2 (en) | 2008-06-17 | 2020-01-07 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US11485746B2 (en) | 2008-06-17 | 2022-11-01 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US10604538B2 (en) | 2008-06-17 | 2020-03-31 | Millenium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
CN102127052A (zh) * | 2011-01-25 | 2011-07-20 | 浙江大学 | 1,4-苯并二恶烷-2-羧酸的合成方法 |
CN102127052B (zh) * | 2011-01-25 | 2013-05-01 | 浙江大学 | 1,4-苯并二恶烷-2-羧酸的合成方法 |
US11241448B2 (en) | 2014-05-20 | 2022-02-08 | Millennium Pharmaceuticals, Inc. | Methods for cancer therapy |
JP2016172768A (ja) * | 2016-06-27 | 2016-09-29 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤 |
JPWO2018159628A1 (ja) * | 2017-02-28 | 2019-12-26 | 国立大学法人北海道大学 | アミノ酸型アシルボランおよびその製造方法 |
WO2018159628A1 (fr) * | 2017-02-28 | 2018-09-07 | 国立大学法人北海道大学 | Acylborane de type acide aminé et procédé pour sa production |
JP7244921B2 (ja) | 2017-02-28 | 2023-03-23 | 国立大学法人北海道大学 | アミノ酸型アシルボランおよびその製造方法 |
JP2021526159A (ja) * | 2018-05-28 | 2021-09-30 | チャンスー チア タイ フェンハイ ファーマシューティカル カンパニー リミテッドJiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd. | ペプチドボロン酸エステル類化合物の合成及び使用 |
JP7314259B2 (ja) | 2018-05-28 | 2023-07-25 | チャンスー チア タイ フェンハイ ファーマシューティカル カンパニー リミテッド | ペプチドボロン酸エステル類化合物の合成及び使用 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2003033506A1 (ja) | 2005-02-03 |
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