JPWO2003033506A1 - アミノボラン酸誘導体およびそれを含有するプロテアソーム阻害薬 - Google Patents
アミノボラン酸誘導体およびそれを含有するプロテアソーム阻害薬 Download PDFInfo
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- JPWO2003033506A1 JPWO2003033506A1 JP2003536245A JP2003536245A JPWO2003033506A1 JP WO2003033506 A1 JPWO2003033506 A1 JP WO2003033506A1 JP 2003536245 A JP2003536245 A JP 2003536245A JP 2003536245 A JP2003536245 A JP 2003536245A JP WO2003033506 A1 JPWO2003033506 A1 JP WO2003033506A1
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- phenylalanyl
- boroleucine
- acetyl
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001314731 | 2001-10-12 | ||
| JP2001314731 | 2001-10-12 | ||
| PCT/JP2002/010450 WO2003033506A1 (fr) | 2001-10-12 | 2002-10-08 | Derive d'acide d'aminoborane et medicament inhibiteur de proteasomes le contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPWO2003033506A1 true JPWO2003033506A1 (ja) | 2005-02-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2003536245A Ceased JPWO2003033506A1 (ja) | 2001-10-12 | 2002-10-08 | アミノボラン酸誘導体およびそれを含有するプロテアソーム阻害薬 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPWO2003033506A1 (fr) |
| WO (1) | WO2003033506A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1463719A2 (fr) | 2002-01-08 | 2004-10-06 | Eisai Co., Ltd | Analogues d'eponemycine et d'epoxomicine et leurs utilisations |
| US7576206B2 (en) * | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| CA2859119A1 (fr) * | 2004-03-30 | 2005-10-20 | Millenium Pharmaceuticals, Inc. | Synthese d'ester borique et de composes acides |
| AU2016202747B2 (en) * | 2004-03-30 | 2017-11-23 | Millennium Pharmaceuticals, Inc. | Synthesis of boronic ester and acid compounds |
| AU2007261345B2 (en) | 2006-06-19 | 2012-02-23 | Onyx Therapeutics, Inc. | Peptide epoxyketones for proteasome inhibition |
| EP2088205A1 (fr) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10 : marqueur de diagnostic et cible thérapeutique de rejet chronique |
| US20090325903A1 (en) | 2008-06-17 | 2009-12-31 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
| US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
| CN102127052B (zh) * | 2011-01-25 | 2013-05-01 | 浙江大学 | 1,4-苯并二恶烷-2-羧酸的合成方法 |
| SG11201609259VA (en) | 2014-05-20 | 2016-12-29 | Millennium Pharm Inc | Boron-containing proteasome inhibitors for use after primary cancer therapy |
| JP6223508B2 (ja) * | 2016-06-27 | 2017-11-01 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロテアソーム阻害剤 |
| WO2018159628A1 (fr) * | 2017-02-28 | 2018-09-07 | 国立大学法人北海道大学 | Acylborane de type acide aminé et procédé pour sa production |
| CN110540547A (zh) * | 2018-05-28 | 2019-12-06 | 秦艳茹 | 一种肽硼酸酯类化合物的合成与用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
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2002
- 2002-10-08 WO PCT/JP2002/010450 patent/WO2003033506A1/fr active Application Filing
- 2002-10-08 JP JP2003536245A patent/JPWO2003033506A1/ja not_active Ceased
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| Publication number | Publication date |
|---|---|
| WO2003033506A1 (fr) | 2003-04-24 |
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